HDAC Inhibition with Valproate Improves Direct Cytotoxicity of Monocytes against Mesothelioma Tumor Cells

HDAC Inhibition with Valproate Improves Direct Cytotoxicity of Monocytes against Mesothelioma Tumor Cells

The composition of the tumor microenvironment (TME) mediates the outcome of chemo- and immunotherapies in malignant pleural mesothelioma (MPM). Tumor-associated macrophages (TAMs) and monocyte myeloid-derived immunosuppressive cells (M-MDSCs) constitute a major fraction of the TME. As central cells...

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Bibliographic Details
Main Authors: Clotilde Hoyos, Alexis Fontaine, Jean-Rock Jacques, Vincent Heinen, Renaud Louis, Bernard Duysinx, Arnaud Scherpereel, Eric Wasielewski, Majeed Jamakhani, Malik Hamaidia, Luc Willems
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
pleural mesothelioma
monocyte
macrophage
tumor microenvironment
histone deacetylase
valproate
Online Access:https://www.mdpi.com/2072-6694/14/9/2164

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