Fingerprinting heterocellular β-adrenoceptor functional expression in the brain using agonist activity profiles

Fingerprinting heterocellular β-adrenoceptor functional expression in the brain using agonist activity profiles

Noradrenergic projections from the brainstem locus coeruleus drive arousal, attentiveness, mood, and memory, but specific adrenoceptor (AR) function across the varied brain cell types has not been extensively characterized, especially with agonists. This study reports a pharmacological analysis of b...

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Bibliographic Details
Main Authors: Rachel A. Matt, Frederick G. Westhorpe, Rosemary F. Romuar, Payal Rana, Joel R. Gever, Anthony P. Ford
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
adrenergic
noradrenergic
GPCR
biased agonism
agonist
desensitization
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1214102/full

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