Renal biopsy in the elderly
Introduction: Kidney disease is very common among the elderly. Over the last decades, the number of renal biopsies performed on these patients has increased. Objective: This study was carried out to examine the frequency and the clinical-pathological correlation of kidney disease in elderly patients...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Spanish |
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Asociación Regional de Diálisis y Trasplantes Renales de Capital Federal y Provincia de Buenos Aires
2016-09-01
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| Series: | Revista de Nefrología, Diálisis y Trasplante |
| Subjects: | |
| Online Access: | http://www.revistarenal.org.ar/index.php/rndt/article/view/71 |
| _version_ | 1818537124309237760 |
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| author | Javier Robaina Graciela De Rosa Marcelo De Rosa Alicia Fernández Federico Fuentes Alicia Marini |
| author_facet | Javier Robaina Graciela De Rosa Marcelo De Rosa Alicia Fernández Federico Fuentes Alicia Marini |
| author_sort | Javier Robaina |
| collection | DOAJ |
| description | Introduction: Kidney disease is very common among the elderly. Over the last decades, the number of renal biopsies performed on these patients has increased. Objective: This study was carried out to examine the frequency and the clinical-pathological correlation of kidney disease in elderly patients who have had a renal biopsy done. Methods: The clinical presentation of kidney disease and the main histological findings were retrospectively analyzed in patients over 65 who had undergone renal biopsy (n=109) for a period of 12 years. Results: The total number of renal biopsies performed during this period was 871, out of which 109 (12.5%) corresponded to patients over 65. The main indications for renal biopsies were nephrotic syndrome (37.6%) and kidney failure (34.9%). Microscopic hematuria was found in 59.6% of the patients and high blood pressure in 62.4% of them. The most frequent histological diagnosis was membranous glomerulonephritis (21.1%), followed by extracapillary glomerulonephritis (20.2%). When clinical syndromes and histological findings were compared, the nephrotic syndrome was found to be the main feature of membranous nephropathy (78.3%), of focal segmental glomerulosclerosis (55.6%) and of diabetic nephropathy (66.7%). Kidney failure was present in 90% of the cases of extracapillary glomerulonephritis (95.5% pauciimmune or type 3). Microscopic hematuria was the main sign of mesangial prolifeative glomerulonephritis (83.3%). Conclusions: Nephrotic syndrome and kidney failure (especially rapidly progressive renal failure) were the main renal biopsy results in this group of patients, bearing close relation to histological findings. The most common types of glomerulonephritis were membranous GN and pauciimmune extracapillary GN. Renal biopsy provides useful information for the diagnosis, prognosis and treatment of kidney disease in the elderly. |
| first_indexed | 2024-12-11T18:46:43Z |
| format | Article |
| id | doaj.art-34a64b963a344d5b98ff5c476e2350ed |
| institution | Directory Open Access Journal |
| issn | 0326-3428 2346-8548 |
| language | Spanish |
| last_indexed | 2024-12-11T18:46:43Z |
| publishDate | 2016-09-01 |
| publisher | Asociación Regional de Diálisis y Trasplantes Renales de Capital Federal y Provincia de Buenos Aires |
| record_format | Article |
| series | Revista de Nefrología, Diálisis y Trasplante |
| spelling | doaj.art-34a64b963a344d5b98ff5c476e2350ed2022-12-22T00:54:26ZspaAsociación Regional de Diálisis y Trasplantes Renales de Capital Federal y Provincia de Buenos AiresRevista de Nefrología, Diálisis y Trasplante0326-34282346-85482016-09-0136315516271Renal biopsy in the elderlyJavier Robaina0Graciela De Rosa1Marcelo De Rosa2Alicia Fernández3Federico Fuentes4Alicia Marini5División Nefrología, Hospital de Clínicas José de San Martín, Buenos AiresDepartamento de Anatomía Patológica, Hospital de Clínicas José de San Martín, Buenos AiresDivisión Nefrología, Hospital de Clínicas José de San Martín, Buenos AiresDivisión Nefrología, Hospital de Clínicas José de San Martín, Buenos AiresDivisión Nefrología, Hospital de Clínicas José de San Martín, Buenos AiresDivisión Nefrología, Hospital de Clínicas José de San Martín, Buenos AiresIntroduction: Kidney disease is very common among the elderly. Over the last decades, the number of renal biopsies performed on these patients has increased. Objective: This study was carried out to examine the frequency and the clinical-pathological correlation of kidney disease in elderly patients who have had a renal biopsy done. Methods: The clinical presentation of kidney disease and the main histological findings were retrospectively analyzed in patients over 65 who had undergone renal biopsy (n=109) for a period of 12 years. Results: The total number of renal biopsies performed during this period was 871, out of which 109 (12.5%) corresponded to patients over 65. The main indications for renal biopsies were nephrotic syndrome (37.6%) and kidney failure (34.9%). Microscopic hematuria was found in 59.6% of the patients and high blood pressure in 62.4% of them. The most frequent histological diagnosis was membranous glomerulonephritis (21.1%), followed by extracapillary glomerulonephritis (20.2%). When clinical syndromes and histological findings were compared, the nephrotic syndrome was found to be the main feature of membranous nephropathy (78.3%), of focal segmental glomerulosclerosis (55.6%) and of diabetic nephropathy (66.7%). Kidney failure was present in 90% of the cases of extracapillary glomerulonephritis (95.5% pauciimmune or type 3). Microscopic hematuria was the main sign of mesangial prolifeative glomerulonephritis (83.3%). Conclusions: Nephrotic syndrome and kidney failure (especially rapidly progressive renal failure) were the main renal biopsy results in this group of patients, bearing close relation to histological findings. The most common types of glomerulonephritis were membranous GN and pauciimmune extracapillary GN. Renal biopsy provides useful information for the diagnosis, prognosis and treatment of kidney disease in the elderly.http://www.revistarenal.org.ar/index.php/rndt/article/view/71adulto mayorbiopsia renalenfermedad renalmanifestaciones clínicaspatología |
| spellingShingle | Javier Robaina Graciela De Rosa Marcelo De Rosa Alicia Fernández Federico Fuentes Alicia Marini Renal biopsy in the elderly Revista de Nefrología, Diálisis y Trasplante adulto mayor biopsia renal enfermedad renal manifestaciones clínicas patología |
| title | Renal biopsy in the elderly |
| title_full | Renal biopsy in the elderly |
| title_fullStr | Renal biopsy in the elderly |
| title_full_unstemmed | Renal biopsy in the elderly |
| title_short | Renal biopsy in the elderly |
| title_sort | renal biopsy in the elderly |
| topic | adulto mayor biopsia renal enfermedad renal manifestaciones clínicas patología |
| url | http://www.revistarenal.org.ar/index.php/rndt/article/view/71 |
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