Immunohistochemistry of non-small cell type of lung cancer can be used as a separate prognostic factor?
Aim We aim to assess prognostic significance of immunohistochemistry represented in Napsin A and CK 5/6 in NSCLC, Moreover we aim to correlate histologic patterns of adenocarcinoma with Napsin A expression and identify its prognostic significance. Patients and methods The study was conducted on 130...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
|
| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
| Subjects: | |
| Online Access: | http://www.ejcdt.eg.net/article.asp?issn=0422-7638;year=2019;volume=68;issue=4;spage=595;epage=600;aulast=Abdel |
| _version_ | 1818696116144701440 |
|---|---|
| author | Manar A Abdel Rahman Eman O Arram Amr Abdel Hamid |
| author_facet | Manar A Abdel Rahman Eman O Arram Amr Abdel Hamid |
| author_sort | Manar A Abdel Rahman |
| collection | DOAJ |
| description | Aim We aim to assess prognostic significance of immunohistochemistry represented in Napsin A and CK 5/6 in NSCLC, Moreover we aim to correlate histologic patterns of adenocarcinoma with Napsin A expression and identify its prognostic significance.
Patients and methods The study was conducted on 130 cases diagnosed pathologically as NSCLC, and then we used Napsin A and CK 5/6 for subtyping them into actual histologic types (108 cases were diagnosed as adenocarcinoma and 22 cases as squamous cell carcinoma, we correlated expression levels of Napsin A and CK 5/6 to different clinicopathological variants.
Results Napsin A score 2 was high in age more than or equal 60 years while Napsin A score 3 was high in age less than 50 years also Napsin A score 3 was high in cases with lymph node metastasis, while CK 5/6 was associated with cases without distant metastasis.
Conclusion Both Napsin A and CK 5/6 could be used as prognostic and diagnostic markers in NSCLC. |
| first_indexed | 2024-12-17T13:56:15Z |
| format | Article |
| id | doaj.art-34a6dc904d2b4688b3a7620cea7d77c3 |
| institution | Directory Open Access Journal |
| issn | 0422-7638 2090-9950 |
| language | English |
| last_indexed | 2024-12-17T13:56:15Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-34a6dc904d2b4688b3a7620cea7d77c32022-12-21T21:45:54ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382090-99502019-01-0168459560010.4103/ejcdt.ejcdt_94_18Immunohistochemistry of non-small cell type of lung cancer can be used as a separate prognostic factor?Manar A Abdel RahmanEman O ArramAmr Abdel HamidAim We aim to assess prognostic significance of immunohistochemistry represented in Napsin A and CK 5/6 in NSCLC, Moreover we aim to correlate histologic patterns of adenocarcinoma with Napsin A expression and identify its prognostic significance. Patients and methods The study was conducted on 130 cases diagnosed pathologically as NSCLC, and then we used Napsin A and CK 5/6 for subtyping them into actual histologic types (108 cases were diagnosed as adenocarcinoma and 22 cases as squamous cell carcinoma, we correlated expression levels of Napsin A and CK 5/6 to different clinicopathological variants. Results Napsin A score 2 was high in age more than or equal 60 years while Napsin A score 3 was high in age less than 50 years also Napsin A score 3 was high in cases with lymph node metastasis, while CK 5/6 was associated with cases without distant metastasis. Conclusion Both Napsin A and CK 5/6 could be used as prognostic and diagnostic markers in NSCLC.http://www.ejcdt.eg.net/article.asp?issn=0422-7638;year=2019;volume=68;issue=4;spage=595;epage=600;aulast=Abdelimmunohistochemistrylung cancerprognosis |
| spellingShingle | Manar A Abdel Rahman Eman O Arram Amr Abdel Hamid Immunohistochemistry of non-small cell type of lung cancer can be used as a separate prognostic factor? Egyptian Journal of Chest Disease and Tuberculosis immunohistochemistry lung cancer prognosis |
| title | Immunohistochemistry of non-small cell type of lung cancer can be used as a separate prognostic factor? |
| title_full | Immunohistochemistry of non-small cell type of lung cancer can be used as a separate prognostic factor? |
| title_fullStr | Immunohistochemistry of non-small cell type of lung cancer can be used as a separate prognostic factor? |
| title_full_unstemmed | Immunohistochemistry of non-small cell type of lung cancer can be used as a separate prognostic factor? |
| title_short | Immunohistochemistry of non-small cell type of lung cancer can be used as a separate prognostic factor? |
| title_sort | immunohistochemistry of non small cell type of lung cancer can be used as a separate prognostic factor |
| topic | immunohistochemistry lung cancer prognosis |
| url | http://www.ejcdt.eg.net/article.asp?issn=0422-7638;year=2019;volume=68;issue=4;spage=595;epage=600;aulast=Abdel |
| work_keys_str_mv | AT manaraabdelrahman immunohistochemistryofnonsmallcelltypeoflungcancercanbeusedasaseparateprognosticfactor AT emanoarram immunohistochemistryofnonsmallcelltypeoflungcancercanbeusedasaseparateprognosticfactor AT amrabdelhamid immunohistochemistryofnonsmallcelltypeoflungcancercanbeusedasaseparateprognosticfactor |