Stress ulcer prophylaxis in patients being weaned from the ventilator in a respiratory care center: A randomized control trial
No data has been available on prophylaxis for stress ulcer development during the process of weaning patients off mechanical ventilators. We conducted a randomized study to evaluate the efficacy of stress ulcer prophylaxis with lansoprazole OD in patients being weaned from mechanical ventilators. Me...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664614002976 |
| _version_ | 1811271771796537344 |
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| author | Chien-Chu Lin Yeong-Long Hsu Chen-Shuan Chung Tzong-Hsi Lee |
| author_facet | Chien-Chu Lin Yeong-Long Hsu Chen-Shuan Chung Tzong-Hsi Lee |
| author_sort | Chien-Chu Lin |
| collection | DOAJ |
| description | No data has been available on prophylaxis for stress ulcer development during the process of weaning patients off mechanical ventilators. We conducted a randomized study to evaluate the efficacy of stress ulcer prophylaxis with lansoprazole OD in patients being weaned from mechanical ventilators.
Methods: A total of 120 patients were randomly allocated into two groups using blocked randomization, with 60 patients in each group. Group A was the treatment group, receiving lansoprazole OD 30 mg from a nasogastric tube for 14 days, while Group B, the control group, received no proton pump inhibitors or other medications for treating peptic ulcers. The primary end point of our study was apparent upper gastrointestinal bleeding within 2 weeks of enrollment.
Results: Apparent upper gastrointestinal bleeding occurred in zero patients and five patients in Groups A and B, respectively (Group A: 0% vs. Group B: 8.3%, p = 0.057). There was no significant difference between the two groups in ventilator-associated pneumonia (Group A: 6.7% vs. Group B: 10.0%, p = 0.509) and 30-day survival rates (Group A: 96.7% vs. Group B: 100%, p = 0.496).
Conclusion: Stress ulcer prophylaxis with lansoprazole in patients being weaned from mechanical ventilators led to a lower but not statistically significant incidence of apparent upper gastrointestinal bleeding. There was no significant increase of incidence of ventilator-associated pneumonia in the prophylaxis group. Further larger scale studies are needed to clarify the benefit of stress ulcer prophylaxis in such patients. |
| first_indexed | 2024-04-12T22:27:03Z |
| format | Article |
| id | doaj.art-34a882f30584410487715eef3f06fea1 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-04-12T22:27:03Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-34a882f30584410487715eef3f06fea12022-12-22T03:14:04ZengElsevierJournal of the Formosan Medical Association0929-66462016-01-011151192410.1016/j.jfma.2014.10.006Stress ulcer prophylaxis in patients being weaned from the ventilator in a respiratory care center: A randomized control trialChien-Chu Lin0Yeong-Long Hsu1Chen-Shuan Chung2Tzong-Hsi Lee3Division of Gastroenterology and Hepatology, Far Eastern Memorial Hospital, New Taipei City, TaiwanDepartment of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, TaiwanDivision of Gastroenterology and Hepatology, Far Eastern Memorial Hospital, New Taipei City, TaiwanDivision of Gastroenterology and Hepatology, Far Eastern Memorial Hospital, New Taipei City, TaiwanNo data has been available on prophylaxis for stress ulcer development during the process of weaning patients off mechanical ventilators. We conducted a randomized study to evaluate the efficacy of stress ulcer prophylaxis with lansoprazole OD in patients being weaned from mechanical ventilators. Methods: A total of 120 patients were randomly allocated into two groups using blocked randomization, with 60 patients in each group. Group A was the treatment group, receiving lansoprazole OD 30 mg from a nasogastric tube for 14 days, while Group B, the control group, received no proton pump inhibitors or other medications for treating peptic ulcers. The primary end point of our study was apparent upper gastrointestinal bleeding within 2 weeks of enrollment. Results: Apparent upper gastrointestinal bleeding occurred in zero patients and five patients in Groups A and B, respectively (Group A: 0% vs. Group B: 8.3%, p = 0.057). There was no significant difference between the two groups in ventilator-associated pneumonia (Group A: 6.7% vs. Group B: 10.0%, p = 0.509) and 30-day survival rates (Group A: 96.7% vs. Group B: 100%, p = 0.496). Conclusion: Stress ulcer prophylaxis with lansoprazole in patients being weaned from mechanical ventilators led to a lower but not statistically significant incidence of apparent upper gastrointestinal bleeding. There was no significant increase of incidence of ventilator-associated pneumonia in the prophylaxis group. Further larger scale studies are needed to clarify the benefit of stress ulcer prophylaxis in such patients.http://www.sciencedirect.com/science/article/pii/S0929664614002976lansoprazole ODproton pump inhibitorrespiratory care centerstress ulcer prophylaxisweaning |
| spellingShingle | Chien-Chu Lin Yeong-Long Hsu Chen-Shuan Chung Tzong-Hsi Lee Stress ulcer prophylaxis in patients being weaned from the ventilator in a respiratory care center: A randomized control trial Journal of the Formosan Medical Association lansoprazole OD proton pump inhibitor respiratory care center stress ulcer prophylaxis weaning |
| title | Stress ulcer prophylaxis in patients being weaned from the ventilator in a respiratory care center: A randomized control trial |
| title_full | Stress ulcer prophylaxis in patients being weaned from the ventilator in a respiratory care center: A randomized control trial |
| title_fullStr | Stress ulcer prophylaxis in patients being weaned from the ventilator in a respiratory care center: A randomized control trial |
| title_full_unstemmed | Stress ulcer prophylaxis in patients being weaned from the ventilator in a respiratory care center: A randomized control trial |
| title_short | Stress ulcer prophylaxis in patients being weaned from the ventilator in a respiratory care center: A randomized control trial |
| title_sort | stress ulcer prophylaxis in patients being weaned from the ventilator in a respiratory care center a randomized control trial |
| topic | lansoprazole OD proton pump inhibitor respiratory care center stress ulcer prophylaxis weaning |
| url | http://www.sciencedirect.com/science/article/pii/S0929664614002976 |
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