MTHFR A1298C Polymorphism and Risk of Preeclampsia: A Meta-Analysis
Background: Published research findings regarding the relationship between the methylenetetrahydrofolate reductase (MTHFR) A1298C polymorphism and the risk of preeclampsia (PE) have generated conflicting results. A meta-analysis was conducted to investigate whether the MTHFR A1298C polymorphism is a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-12-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/50/12/10.31083/j.ceog5012266 |
| _version_ | 1797365351658291200 |
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| author | Yong Hu Ao Wang Ke Yi |
| author_facet | Yong Hu Ao Wang Ke Yi |
| author_sort | Yong Hu |
| collection | DOAJ |
| description | Background: Published research findings regarding the relationship between the methylenetetrahydrofolate reductase (MTHFR) A1298C polymorphism and the risk of preeclampsia (PE) have generated conflicting results. A meta-analysis was conducted to investigate whether the MTHFR A1298C polymorphism is associated with preeclampsia. Methods: We conducted a systematic search across several databases, including PubMed, Embase, Web of science, China National Knowledge Infrastructure, and Chinese Biomedicine Databases, to identify relevant studies. We then calculated pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) to assess the association between the MTHFR A1298C polymorphism and preeclampsia (PE) risk. Results: A total of 11 studies were enrolled in this meta-analysis. The pooled analyses revealed that MTHFR A1298C polymorphism significantly decreased the risk of PE (allele contrast (A (alanine) vs. C (glutamate) ): OR, 0.81; 95% CI, 0.71–0.93, p = 0.207; homozygote (AA vs. CC): OR, 0.57; 95% CI, 0.40–0.79, p = 0.056; heterozygote (AC vs. CC): OR, 0.62; 95% CI, 0.45–0.87, p = 0.010; dominant model (AA + AC vs. CC): OR, 0.59; 95% CI, 0.43–0.81, p = 0.031; recessive model (AA vs. AC + CC): OR, 0.83; 95% CI, 0.70–0.98), p = 0.817. Conclusion: Present meta-analysis reveals that MTHFR A1298C variant may serve as genetic biomarkers of PE. The study was registered on PROSPERO (https://www.crd.york.ac.uk/prospero/), registration number: CRD42023459681. |
| first_indexed | 2024-03-08T16:47:50Z |
| format | Article |
| id | doaj.art-34a9b4836a3d4c539150cbb945493106 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-03-08T16:47:50Z |
| publishDate | 2023-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-34a9b4836a3d4c539150cbb9454931062024-01-05T07:27:09ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-12-01501226610.31083/j.ceog5012266S0390-6663(23)02234-0MTHFR A1298C Polymorphism and Risk of Preeclampsia: A Meta-AnalysisYong Hu0Ao Wang1Ke Yi2Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, 610041 Chengdu, Sichuan, ChinaKey Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of the Ministry of Education, West China Second University Hospital, Sichuan University, 610041 Chengdu, Sichuan, ChinaKey Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of the Ministry of Education, West China Second University Hospital, Sichuan University, 610041 Chengdu, Sichuan, ChinaBackground: Published research findings regarding the relationship between the methylenetetrahydrofolate reductase (MTHFR) A1298C polymorphism and the risk of preeclampsia (PE) have generated conflicting results. A meta-analysis was conducted to investigate whether the MTHFR A1298C polymorphism is associated with preeclampsia. Methods: We conducted a systematic search across several databases, including PubMed, Embase, Web of science, China National Knowledge Infrastructure, and Chinese Biomedicine Databases, to identify relevant studies. We then calculated pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) to assess the association between the MTHFR A1298C polymorphism and preeclampsia (PE) risk. Results: A total of 11 studies were enrolled in this meta-analysis. The pooled analyses revealed that MTHFR A1298C polymorphism significantly decreased the risk of PE (allele contrast (A (alanine) vs. C (glutamate) ): OR, 0.81; 95% CI, 0.71–0.93, p = 0.207; homozygote (AA vs. CC): OR, 0.57; 95% CI, 0.40–0.79, p = 0.056; heterozygote (AC vs. CC): OR, 0.62; 95% CI, 0.45–0.87, p = 0.010; dominant model (AA + AC vs. CC): OR, 0.59; 95% CI, 0.43–0.81, p = 0.031; recessive model (AA vs. AC + CC): OR, 0.83; 95% CI, 0.70–0.98), p = 0.817. Conclusion: Present meta-analysis reveals that MTHFR A1298C variant may serve as genetic biomarkers of PE. The study was registered on PROSPERO (https://www.crd.york.ac.uk/prospero/), registration number: CRD42023459681.https://www.imrpress.com/journal/CEOG/50/12/10.31083/j.ceog5012266mthfrpolymorphismspreeclampsiameta-analysis |
| spellingShingle | Yong Hu Ao Wang Ke Yi MTHFR A1298C Polymorphism and Risk of Preeclampsia: A Meta-Analysis Clinical and Experimental Obstetrics & Gynecology mthfr polymorphisms preeclampsia meta-analysis |
| title | MTHFR A1298C Polymorphism and Risk of Preeclampsia: A Meta-Analysis |
| title_full | MTHFR A1298C Polymorphism and Risk of Preeclampsia: A Meta-Analysis |
| title_fullStr | MTHFR A1298C Polymorphism and Risk of Preeclampsia: A Meta-Analysis |
| title_full_unstemmed | MTHFR A1298C Polymorphism and Risk of Preeclampsia: A Meta-Analysis |
| title_short | MTHFR A1298C Polymorphism and Risk of Preeclampsia: A Meta-Analysis |
| title_sort | mthfr a1298c polymorphism and risk of preeclampsia a meta analysis |
| topic | mthfr polymorphisms preeclampsia meta-analysis |
| url | https://www.imrpress.com/journal/CEOG/50/12/10.31083/j.ceog5012266 |
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