Whey protein isolate supplementation improves body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy
Abstract In recent years, whey proteins (WP) have attracted increasing attention in health and disease for their bioactive functions. The aim of this study was to evaluate the benefit of WP isolate (WPI) supplementation in addition to nutritional counseling in malnourished advanced cancer patients u...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-11-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.2517 |
| _version_ | 1797264977199890432 |
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| author | Emanuele Cereda Annalisa Turri Catherine Klersy Silvia Cappello Alessandra Ferrari Andrea Riccardo Filippi Silvia Brugnatelli Marilisa Caraccia Silvia Chiellino Valeria Borioli Teresa Monaco Giulia Maria Stella Luca Arcaini Marco Benazzo Giuseppina Grugnetti Paolo Pedrazzoli Riccardo Caccialanza |
| author_facet | Emanuele Cereda Annalisa Turri Catherine Klersy Silvia Cappello Alessandra Ferrari Andrea Riccardo Filippi Silvia Brugnatelli Marilisa Caraccia Silvia Chiellino Valeria Borioli Teresa Monaco Giulia Maria Stella Luca Arcaini Marco Benazzo Giuseppina Grugnetti Paolo Pedrazzoli Riccardo Caccialanza |
| author_sort | Emanuele Cereda |
| collection | DOAJ |
| description | Abstract In recent years, whey proteins (WP) have attracted increasing attention in health and disease for their bioactive functions. The aim of this study was to evaluate the benefit of WP isolate (WPI) supplementation in addition to nutritional counseling in malnourished advanced cancer patients undergoing chemotherapy (CT). In a single‐center, randomized, pragmatic, and parallel‐group controlled trial (ClinicalTrials.gov: NCT02065726), 166 malnourished advanced cancer patients with mixed tumor entities candidate to or undergoing CT were randomly assigned to receive nutritional counseling with (N = 82) or without (N = 84) WPI supplementation (20 g/d) for 3 months. The primary endpoint was the change in phase angle (PhA). Secondary endpoints included changes in standardized PhA (SPA), fat‐free mass index (FFMI), body weight, muscle strength, and CT toxicity (CTCAE 4.0 events). In patients with the primary endpoint assessed (modified intention‐to‐treat population), counseling plus WPI (N = 66) resulted in improved PhA compared to nutritional counseling alone (N = 69): mean difference, 0.48° (95% CI, 0.05 to 0.90) (P = .027). WPI supplementation also resulted in improved SPA (P = .021), FFMI (P = .041), body weight (P = .023), muscle strength (P < .001), and in a reduced risk of CT toxicity (risk difference, −9.8% [95% CI, −16.9 to −2.6]; P = .009), particularly of severe (grade ≥ 3) events (risk difference, −30.4% [95% CI, −44.4 to −16.5]; P = .001). In malnourished advanced cancer patients undergoing CT, receiving nutritional counseling, a 3‐month supplementation with WPI resulted in improved body composition, muscle strength, body weight, and reduced CT toxicity. Further trials, aimed at verifying the efficacy of this nutritional intervention on mid‐ and long‐term primary clinical endpoints in newly diagnosed specific cancer types, are warranted. |
| first_indexed | 2024-04-25T00:37:28Z |
| format | Article |
| id | doaj.art-34abc5165f2f45c3ab1632411d90738c |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-25T00:37:28Z |
| publishDate | 2019-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-34abc5165f2f45c3ab1632411d90738c2024-03-12T14:35:41ZengWileyCancer Medicine2045-76342019-11-018166923693210.1002/cam4.2517Whey protein isolate supplementation improves body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapyEmanuele Cereda0Annalisa Turri1Catherine Klersy2Silvia Cappello3Alessandra Ferrari4Andrea Riccardo Filippi5Silvia Brugnatelli6Marilisa Caraccia7Silvia Chiellino8Valeria Borioli9Teresa Monaco10Giulia Maria Stella11Luca Arcaini12Marco Benazzo13Giuseppina Grugnetti14Paolo Pedrazzoli15Riccardo Caccialanza16Clinical Nutrition and Dietetics Unit Fondazione IRCCS Policlinico San Matteo Pavia ItalyClinical Nutrition and Dietetics Unit Fondazione IRCCS Policlinico San Matteo Pavia ItalyBiometry and Clinical Epidemiology Service Fondazione IRCCS Policlinico San Matteo Pavia ItalyClinical Nutrition and Dietetics Unit Fondazione IRCCS Policlinico San Matteo Pavia ItalyMedical Oncology Unit Fondazione IRCCS Policlinico San Matteo Pavia ItalyRadiation Oncology Unit Fondazione IRCCS Policlinico San Matteo Pavia ItalyMedical Oncology Unit Fondazione IRCCS Policlinico San Matteo Pavia ItalyClinical Nutrition and Dietetics Unit Fondazione IRCCS Policlinico San Matteo Pavia ItalyMedical Oncology Unit Fondazione IRCCS Policlinico San Matteo Pavia ItalyClinical Nutrition and Dietetics Unit Fondazione IRCCS Policlinico San Matteo Pavia ItalyMedical Oncology Unit Fondazione IRCCS Policlinico San Matteo Pavia ItalyUnit of Respiratory System Diseases Fondazione IRCCS Policlinico San Matteo Pavia ItalyDivision of Hematology Fondazione IRCCS Policlinico San Matteo Pavia ItalyDepartment of Otolaryngology University of Pavia Pavia ItalyNursing Technical and Rehabilitation Service Fondazione IRCCS Policlinico San Matteo Pavia ItalyMedical Oncology Unit Fondazione IRCCS Policlinico San Matteo Pavia ItalyClinical Nutrition and Dietetics Unit Fondazione IRCCS Policlinico San Matteo Pavia ItalyAbstract In recent years, whey proteins (WP) have attracted increasing attention in health and disease for their bioactive functions. The aim of this study was to evaluate the benefit of WP isolate (WPI) supplementation in addition to nutritional counseling in malnourished advanced cancer patients undergoing chemotherapy (CT). In a single‐center, randomized, pragmatic, and parallel‐group controlled trial (ClinicalTrials.gov: NCT02065726), 166 malnourished advanced cancer patients with mixed tumor entities candidate to or undergoing CT were randomly assigned to receive nutritional counseling with (N = 82) or without (N = 84) WPI supplementation (20 g/d) for 3 months. The primary endpoint was the change in phase angle (PhA). Secondary endpoints included changes in standardized PhA (SPA), fat‐free mass index (FFMI), body weight, muscle strength, and CT toxicity (CTCAE 4.0 events). In patients with the primary endpoint assessed (modified intention‐to‐treat population), counseling plus WPI (N = 66) resulted in improved PhA compared to nutritional counseling alone (N = 69): mean difference, 0.48° (95% CI, 0.05 to 0.90) (P = .027). WPI supplementation also resulted in improved SPA (P = .021), FFMI (P = .041), body weight (P = .023), muscle strength (P < .001), and in a reduced risk of CT toxicity (risk difference, −9.8% [95% CI, −16.9 to −2.6]; P = .009), particularly of severe (grade ≥ 3) events (risk difference, −30.4% [95% CI, −44.4 to −16.5]; P = .001). In malnourished advanced cancer patients undergoing CT, receiving nutritional counseling, a 3‐month supplementation with WPI resulted in improved body composition, muscle strength, body weight, and reduced CT toxicity. Further trials, aimed at verifying the efficacy of this nutritional intervention on mid‐ and long‐term primary clinical endpoints in newly diagnosed specific cancer types, are warranted.https://doi.org/10.1002/cam4.2517cancermalnutritionnutritional counselingwhey proteins |
| spellingShingle | Emanuele Cereda Annalisa Turri Catherine Klersy Silvia Cappello Alessandra Ferrari Andrea Riccardo Filippi Silvia Brugnatelli Marilisa Caraccia Silvia Chiellino Valeria Borioli Teresa Monaco Giulia Maria Stella Luca Arcaini Marco Benazzo Giuseppina Grugnetti Paolo Pedrazzoli Riccardo Caccialanza Whey protein isolate supplementation improves body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy Cancer Medicine cancer malnutrition nutritional counseling whey proteins |
| title | Whey protein isolate supplementation improves body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy |
| title_full | Whey protein isolate supplementation improves body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy |
| title_fullStr | Whey protein isolate supplementation improves body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy |
| title_full_unstemmed | Whey protein isolate supplementation improves body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy |
| title_short | Whey protein isolate supplementation improves body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy |
| title_sort | whey protein isolate supplementation improves body composition muscle strength and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy |
| topic | cancer malnutrition nutritional counseling whey proteins |
| url | https://doi.org/10.1002/cam4.2517 |
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