Redox modulation of thimet oligopeptidase activity by hydrogen peroxide

Redox modulation of thimet oligopeptidase activity by hydrogen peroxide

Thimet oligopeptidase (EC 3.4.24.15, TOP) is a cytosolic mammalian zinc protease that can process a diversity of bioactive peptides. TOP has been pointed out as one of the main postproteasomal enzymes that process peptide antigens in the MHC class I presentation route. In the present study, we descr...

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Bibliographic Details
Main Authors: Marcelo Y. Icimoto, Juliana C. Ferreira, César H. Yokomizo, Larissa V. Bim, Alyne Marem, Joyce M. Gilio, Vitor Oliveira, Iseli L. Nantes
Format: Article
Language:English
Published: Wiley 2017-07-01
Series:FEBS Open Bio
Subjects:
EC 3.4.24.15
hydrogen peroxide
protein oxidation
thioredoxin
Online Access:https://doi.org/10.1002/2211-5463.12245

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