Budd–Chiari Syndrome as an Initial Presentation of Systemic Lupus Erythematosus Associated with Antiphospholipid Syndrome: A Case Report with Review of the Literature
Gashaw Solela,1 Merga Daba2 1Department of Internal Medicine, Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia; 2Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Gashaw Solela, Department of Internal Medicine, Yekatit...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-08-01
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| Series: | Open Access Rheumatology: Research and Reviews |
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| Online Access: | https://www.dovepress.com/buddchiari-syndrome-as-an-initial-presentation-of-systemic-lupus-eryth-peer-reviewed-fulltext-article-OARRR |
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| author | Solela G Daba M |
| author_facet | Solela G Daba M |
| author_sort | Solela G |
| collection | DOAJ |
| description | Gashaw Solela,1 Merga Daba2 1Department of Internal Medicine, Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia; 2Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Gashaw Solela, Department of Internal Medicine, Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia, Email gashawsol@gmail.comIntroduction: Budd–Chiari syndrome (BCS) is a rare disorder characterized by hepatic outflow obstruction. It can be classified as primary or secondary BCS. Common causes of BCS include myeloproliferative diseases, infections, malignancies, and systemic autoimmune illnesses. Systemic lupus erythematosus (SLE) can be complicated with BCS. However, only a few case reports have described the uncommon occurrence of BCS as a primary presentation of SLE.Case Presentation: We report the case of a 32-year-old female patient who presented with progressive abdominal distension of four months. On the abdominal CT scan, the left and middle hepatic veins were not visualized; the right hepatic vein and intrahepatic IVC had luminal narrowing; and there was caudate lobe enlargement suggestive of Budd–Chiari syndrome (BCS). Six months after the diagnosis of BCS, the patient developed other clinical features suggestive of systemic lupus erythematosus (SLE) and was finally diagnosed with SLE.Conclusion: Acquired or inherited thrombotic conditions are the most common underlying causes of Budd–Chiari syndrome. Systemic lupus erythematosus (SLE) is the most common cause of secondary APS and most patients present with Budd–Chiari syndrome as a manifestation of APS after the diagnosis of SLE. In rare cases, such as the current case, Budd–Chiari syndrome can present even before the diagnosis of SLE. Hence, we would like to emphasize that Budd–Chiari syndrome can be an initial presentation of SLE.Keywords: Budd–Chiari syndrome, systemic lupus erythematosus, antiphospholipid syndrome |
| first_indexed | 2024-03-12T14:14:20Z |
| format | Article |
| id | doaj.art-34ad0945e16140dd9aa7df370fb7c2a0 |
| institution | Directory Open Access Journal |
| issn | 1179-156X |
| language | English |
| last_indexed | 2024-03-12T14:14:20Z |
| publishDate | 2023-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Open Access Rheumatology: Research and Reviews |
| spelling | doaj.art-34ad0945e16140dd9aa7df370fb7c2a02023-08-20T18:53:13ZengDove Medical PressOpen Access Rheumatology: Research and Reviews1179-156X2023-08-01Volume 1513914385981Budd–Chiari Syndrome as an Initial Presentation of Systemic Lupus Erythematosus Associated with Antiphospholipid Syndrome: A Case Report with Review of the LiteratureSolela GDaba MGashaw Solela,1 Merga Daba2 1Department of Internal Medicine, Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia; 2Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Gashaw Solela, Department of Internal Medicine, Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia, Email gashawsol@gmail.comIntroduction: Budd–Chiari syndrome (BCS) is a rare disorder characterized by hepatic outflow obstruction. It can be classified as primary or secondary BCS. Common causes of BCS include myeloproliferative diseases, infections, malignancies, and systemic autoimmune illnesses. Systemic lupus erythematosus (SLE) can be complicated with BCS. However, only a few case reports have described the uncommon occurrence of BCS as a primary presentation of SLE.Case Presentation: We report the case of a 32-year-old female patient who presented with progressive abdominal distension of four months. On the abdominal CT scan, the left and middle hepatic veins were not visualized; the right hepatic vein and intrahepatic IVC had luminal narrowing; and there was caudate lobe enlargement suggestive of Budd–Chiari syndrome (BCS). Six months after the diagnosis of BCS, the patient developed other clinical features suggestive of systemic lupus erythematosus (SLE) and was finally diagnosed with SLE.Conclusion: Acquired or inherited thrombotic conditions are the most common underlying causes of Budd–Chiari syndrome. Systemic lupus erythematosus (SLE) is the most common cause of secondary APS and most patients present with Budd–Chiari syndrome as a manifestation of APS after the diagnosis of SLE. In rare cases, such as the current case, Budd–Chiari syndrome can present even before the diagnosis of SLE. Hence, we would like to emphasize that Budd–Chiari syndrome can be an initial presentation of SLE.Keywords: Budd–Chiari syndrome, systemic lupus erythematosus, antiphospholipid syndromehttps://www.dovepress.com/buddchiari-syndrome-as-an-initial-presentation-of-systemic-lupus-eryth-peer-reviewed-fulltext-article-OARRRbudd–chiari syndromesystemic lupus erythematosusantiphospholipid syndrome |
| spellingShingle | Solela G Daba M Budd–Chiari Syndrome as an Initial Presentation of Systemic Lupus Erythematosus Associated with Antiphospholipid Syndrome: A Case Report with Review of the Literature Open Access Rheumatology: Research and Reviews budd–chiari syndrome systemic lupus erythematosus antiphospholipid syndrome |
| title | Budd–Chiari Syndrome as an Initial Presentation of Systemic Lupus Erythematosus Associated with Antiphospholipid Syndrome: A Case Report with Review of the Literature |
| title_full | Budd–Chiari Syndrome as an Initial Presentation of Systemic Lupus Erythematosus Associated with Antiphospholipid Syndrome: A Case Report with Review of the Literature |
| title_fullStr | Budd–Chiari Syndrome as an Initial Presentation of Systemic Lupus Erythematosus Associated with Antiphospholipid Syndrome: A Case Report with Review of the Literature |
| title_full_unstemmed | Budd–Chiari Syndrome as an Initial Presentation of Systemic Lupus Erythematosus Associated with Antiphospholipid Syndrome: A Case Report with Review of the Literature |
| title_short | Budd–Chiari Syndrome as an Initial Presentation of Systemic Lupus Erythematosus Associated with Antiphospholipid Syndrome: A Case Report with Review of the Literature |
| title_sort | budd ndash chiari syndrome as an initial presentation of systemic lupus erythematosus associated with antiphospholipid syndrome a case report with review of the literature |
| topic | budd–chiari syndrome systemic lupus erythematosus antiphospholipid syndrome |
| url | https://www.dovepress.com/buddchiari-syndrome-as-an-initial-presentation-of-systemic-lupus-eryth-peer-reviewed-fulltext-article-OARRR |
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