Determination of the role of polymorphic variants of the interferon-gamma gene (<i>IFNG</i>) in the development of tuberculosis in the Yakut population
The objective of the study: to determine the role of polymorphic variants T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the development of tuberculosis in the population of Yakut nationality.Subjects and methods. The case-control study was conducted. The subject for the study was DNA sa...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2021-01-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1490 |
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| author | L. I. Mordovskaya M. V. Egorova T. M. Klimova S. D. Аlekseeva |
| author_facet | L. I. Mordovskaya M. V. Egorova T. M. Klimova S. D. Аlekseeva |
| author_sort | L. I. Mordovskaya |
| collection | DOAJ |
| description | The objective of the study: to determine the role of polymorphic variants T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the development of tuberculosis in the population of Yakut nationality.Subjects and methods. The case-control study was conducted. The subject for the study was DNA samples from 172 tuberculosis patients (the case group) and 367 people with an excluded diagnosis of tuberculosis (the control group). All participants of the study belonged to Yakut nationality. For genotyping, DNA was isolated from venous blood. The genotyping was performed by real-time polymerase chain reaction. For statistical processing, Pearson's χ2 test and odds ratio with 95% confidence intervals were used.The results of the study showed that the distribution of genotypes of polymorphisms T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the case and control groups corresponded to the Hardy – Weinberg equilibrium. There was no statistically significant difference in frequencies of alleles and genotypes of polymorphisms T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the patients from the case and control groups.Conclusions. The results of the study did not reveal the association of alleles and genotypes of the rs2430561 and rs2069718 polymorphic variants of the IFNG gene with the risk of developing tuberculosis for people of Yakut nationality. |
| first_indexed | 2024-03-12T04:23:44Z |
| format | Article |
| id | doaj.art-34aebb5c8c004d859ad3328e77f1d805 |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2024-03-12T04:23:44Z |
| publishDate | 2021-01-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-34aebb5c8c004d859ad3328e77f1d8052023-09-03T10:32:24ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062021-01-019812273210.21292/2075-1230-2020-98-12-27-321487Determination of the role of polymorphic variants of the interferon-gamma gene (<i>IFNG</i>) in the development of tuberculosis in the Yakut populationL. I. Mordovskaya0M. V. Egorova1T. M. Klimova2S. D. Аlekseeva3ГБУ РС (Я) «Научно-практический центр "Фтизиатрия"»; Медицинский институт ФГАОУ ВО «Северо-Восточный федеральный университет им. М. К. Аммосова»ГБУ РС (Я) «Научно-практический центр "Фтизиатрия"»Медицинский институт ФГАОУ ВО «Северо-Восточный федеральный университет им. М. К. Аммосова»; Якутский научный центр комплексных медицинских проблемГБУ РС (Я) «Научно-практический центр "Фтизиатрия"»The objective of the study: to determine the role of polymorphic variants T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the development of tuberculosis in the population of Yakut nationality.Subjects and methods. The case-control study was conducted. The subject for the study was DNA samples from 172 tuberculosis patients (the case group) and 367 people with an excluded diagnosis of tuberculosis (the control group). All participants of the study belonged to Yakut nationality. For genotyping, DNA was isolated from venous blood. The genotyping was performed by real-time polymerase chain reaction. For statistical processing, Pearson's χ2 test and odds ratio with 95% confidence intervals were used.The results of the study showed that the distribution of genotypes of polymorphisms T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the case and control groups corresponded to the Hardy – Weinberg equilibrium. There was no statistically significant difference in frequencies of alleles and genotypes of polymorphisms T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the patients from the case and control groups.Conclusions. The results of the study did not reveal the association of alleles and genotypes of the rs2430561 and rs2069718 polymorphic variants of the IFNG gene with the risk of developing tuberculosis for people of Yakut nationality.https://www.tibl-journal.com/jour/article/view/1490туберкулезполиморфизмген <i>ifng</i>якутская популяция |
| spellingShingle | L. I. Mordovskaya M. V. Egorova T. M. Klimova S. D. Аlekseeva Determination of the role of polymorphic variants of the interferon-gamma gene (<i>IFNG</i>) in the development of tuberculosis in the Yakut population Туберкулез и болезни лёгких туберкулез полиморфизм ген <i>ifng</i> якутская популяция |
| title | Determination of the role of polymorphic variants of the interferon-gamma gene (<i>IFNG</i>) in the development of tuberculosis in the Yakut population |
| title_full | Determination of the role of polymorphic variants of the interferon-gamma gene (<i>IFNG</i>) in the development of tuberculosis in the Yakut population |
| title_fullStr | Determination of the role of polymorphic variants of the interferon-gamma gene (<i>IFNG</i>) in the development of tuberculosis in the Yakut population |
| title_full_unstemmed | Determination of the role of polymorphic variants of the interferon-gamma gene (<i>IFNG</i>) in the development of tuberculosis in the Yakut population |
| title_short | Determination of the role of polymorphic variants of the interferon-gamma gene (<i>IFNG</i>) in the development of tuberculosis in the Yakut population |
| title_sort | determination of the role of polymorphic variants of the interferon gamma gene i ifng i in the development of tuberculosis in the yakut population |
| topic | туберкулез полиморфизм ген <i>ifng</i> якутская популяция |
| url | https://www.tibl-journal.com/jour/article/view/1490 |
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