KuINins as a New Class of HIV-1 Inhibitors That Block Post-Integration DNA Repair

KuINins as a New Class of HIV-1 Inhibitors That Block Post-Integration DNA Repair

Integration of HIV-1 genomic cDNA results in the formation of single-strand breaks in cellular DNA, which must be repaired for efficient viral replication. Post-integration DNA repair mainly depends on the formation of the HIV-1 integrase complex with the Ku70 protein, which promotes DNA-PK assembly...

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Bibliographic Details
Main Authors: Andrey Anisenko, Simon Galkin, Andrey A. Mikhaylov, Maria G. Khrenova, Yulia Agapkina, Sergey Korolev, Lidia Garkul, Vasilissa Shirokova, Viktoria A. Ikonnikova, Alexander Korlyukov, Pavel Dorovatovskii, Mikhail Baranov, Marina Gottikh
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
HIV-1
integrase
Ku70
DNA-PK
post-integration repair
inhibitor of protein–protein interaction
Online Access:https://www.mdpi.com/1422-0067/24/24/17354

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