Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats
Multienzyme 2-oxoglutarate complex (2-OGDH) together with branched chain ?-ketoacid dehydrogenase (BCKDH) and pyruvate dehydrogenase belong to the family of mitochondrial 2-oxoacid dehydrogenases. Hypolipidemic drugs, bezafibrate and fenofibrate, up-regulate liver BCKDH. The present study has been...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bangladesh Pharmacological Society
2015-07-01
|
| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/23101 |
| _version_ | 1811287170667773952 |
|---|---|
| author | Malgorzata Elzbieta Knapik-Czajka |
| author_facet | Malgorzata Elzbieta Knapik-Czajka |
| author_sort | Malgorzata Elzbieta Knapik-Czajka |
| collection | DOAJ |
| description | Multienzyme 2-oxoglutarate complex (2-OGDH) together with branched chain ?-ketoacid dehydrogenase (BCKDH) and pyruvate dehydrogenase belong to the family of mitochondrial 2-oxoacid dehydrogenases. Hypolipidemic drugs, bezafibrate and fenofibrate, up-regulate liver BCKDH. The present study has been undertaken to determine the effect of low doses of bezafibrate and fenofibrate on liver 2-OGDH. Fibrates were administrated to rats fed low-protein diet at 5, 10 or 20 mg/kg. In rats treated with increasing doses of bezafibrate 2-OGDH activity increased by 7, 35 and 42%, while in rats administered with fenofibrate by 8, 18, and 56% (p<0.05 for bezafibrate 10 and 20, and fenofibrate 20 mg/kg). Changes in 2-OGDH activity did not correspond with changes in mRNA levels of the complex enzymes. Moreover, mRNA levels of PPAR? remained unaltered. It is conceivable that stimulation of 2-OGDH activity by low doses of fibrates is the result of post-transcriptional events and may have a significant effect on liver metabolism. |
| first_indexed | 2024-04-13T03:13:50Z |
| format | Article |
| id | doaj.art-34b4993ac8c3451eac9b0bdcf3a02738 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-04-13T03:13:50Z |
| publishDate | 2015-07-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-34b4993ac8c3451eac9b0bdcf3a027382022-12-22T03:04:58ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882015-07-01103Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed ratsMalgorzata Elzbieta Knapik-Czajka0Department of Analytical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, KrakowMultienzyme 2-oxoglutarate complex (2-OGDH) together with branched chain ?-ketoacid dehydrogenase (BCKDH) and pyruvate dehydrogenase belong to the family of mitochondrial 2-oxoacid dehydrogenases. Hypolipidemic drugs, bezafibrate and fenofibrate, up-regulate liver BCKDH. The present study has been undertaken to determine the effect of low doses of bezafibrate and fenofibrate on liver 2-OGDH. Fibrates were administrated to rats fed low-protein diet at 5, 10 or 20 mg/kg. In rats treated with increasing doses of bezafibrate 2-OGDH activity increased by 7, 35 and 42%, while in rats administered with fenofibrate by 8, 18, and 56% (p<0.05 for bezafibrate 10 and 20, and fenofibrate 20 mg/kg). Changes in 2-OGDH activity did not correspond with changes in mRNA levels of the complex enzymes. Moreover, mRNA levels of PPAR? remained unaltered. It is conceivable that stimulation of 2-OGDH activity by low doses of fibrates is the result of post-transcriptional events and may have a significant effect on liver metabolism.https://www.banglajol.info/index.php/BJP/article/view/23101BezafibrateFenofibrate2-Oxoglutarate dehydrogenase |
| spellingShingle | Malgorzata Elzbieta Knapik-Czajka Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats Bangladesh Journal of Pharmacology Bezafibrate Fenofibrate 2-Oxoglutarate dehydrogenase |
| title | Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats |
| title_full | Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats |
| title_fullStr | Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats |
| title_full_unstemmed | Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats |
| title_short | Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats |
| title_sort | effect of low doses of bezafibrate and fenofibrate on liver 2 oxo glutarate dehydrogenase complex in low protein diet fed rats |
| topic | Bezafibrate Fenofibrate 2-Oxoglutarate dehydrogenase |
| url | https://www.banglajol.info/index.php/BJP/article/view/23101 |
| work_keys_str_mv | AT malgorzataelzbietaknapikczajka effectoflowdosesofbezafibrateandfenofibrateonliver2oxoglutaratedehydrogenasecomplexinlowproteindietfedrats |