Changes in mouse thymus after exposure to tube-restraint stress
The thymus is the primary lymphoid organ involved in the regulation of the immune and endocrine systems. It is particularly sensitive to various types of stress, which induce its atrophy. This study deals with the effect of repeated restraint stress on the weight, proliferation and apoptosis of the...
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2020-01-01
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| Series: | Archives of Biological Sciences |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2020/0354-46641900060D.pdf |
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| author | Drljača Jovana N. Vejnović Ana-Marija T. Miljković Dejan M. Popović Milan J. Rakić Dušica B. Sekulić Slobodan R. Čapo Ivan Đ. Petković Branka B. |
| author_facet | Drljača Jovana N. Vejnović Ana-Marija T. Miljković Dejan M. Popović Milan J. Rakić Dušica B. Sekulić Slobodan R. Čapo Ivan Đ. Petković Branka B. |
| author_sort | Drljača Jovana N. |
| collection | DOAJ |
| description | The thymus is the primary lymphoid organ involved in the regulation of the immune and endocrine systems. It is particularly sensitive to various types of stress, which induce its atrophy. This study deals with the effect of repeated restraint stress on the weight, proliferation and apoptosis of the thymus in mice. During restraint, the animals were placed in 50-mL conical plastic tubes for 2 h every day for either 10 or 20 consecutive days. A significant reduction in thymus weight along with decreased cellularity and pronounced atrophy of the cortical part of the thymus was observed in animals exposed to repeated tube-restraint stress for 10 and 20 consecutive days. The observed changes in the thymus were the same, regardless of the number of days of exposure to stress. These findings provide a more comprehensive view of repeated tube-restraint, with special emphasis on its duration on stress-induced thymus atrophy. The presented findings could serve as a basis for further studies aimed at identifying the mechanisms responsible for the adaptive response of the thymus after repeated exposure to stress. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 175006] |
| first_indexed | 2024-12-15T00:33:28Z |
| format | Article |
| id | doaj.art-34b57fe668dc4939a70c9f59c13aaf78 |
| institution | Directory Open Access Journal |
| issn | 0354-4664 1821-4339 |
| language | English |
| last_indexed | 2024-12-15T00:33:28Z |
| publishDate | 2020-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-34b57fe668dc4939a70c9f59c13aaf782022-12-21T22:41:54ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392020-01-0172151110.2298/ABS190716060D0354-46641900060DChanges in mouse thymus after exposure to tube-restraint stressDrljača Jovana N.0Vejnović Ana-Marija T.1Miljković Dejan M.2Popović Milan J.3Rakić Dušica B.4Sekulić Slobodan R.5Čapo Ivan Đ.6Petković Branka B.7Faculty of Medicine, University of Novi Sad, Novi Sad, SerbiaDepartment of Psychiatry and Medical Psychology, Faculty of Medicine, University of Novi Sad, Novi Sad, SerbiaDepartment of Histology and Embryology, Faculty of Medicine, University of Novi Sad, Novi Sad, SerbiaDepartment of Histology and Embryology, Faculty of Medicine, University of Novi Sad, Novi Sad, SerbiaDepartment of General Education Subjects, Faculty of Medicine, University of Novi Sad, Novi Sad, SerbiaDepartment of Neurology, Faculty of Medicine, University of Novi Sad, Novi Sad, SerbiaDepartment of Histology and Embryology, Faculty of Medicine, University of Novi Sad, Novi Sad, SerbiaDepartment of Neurophysiology, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Belgrade, SerbiaThe thymus is the primary lymphoid organ involved in the regulation of the immune and endocrine systems. It is particularly sensitive to various types of stress, which induce its atrophy. This study deals with the effect of repeated restraint stress on the weight, proliferation and apoptosis of the thymus in mice. During restraint, the animals were placed in 50-mL conical plastic tubes for 2 h every day for either 10 or 20 consecutive days. A significant reduction in thymus weight along with decreased cellularity and pronounced atrophy of the cortical part of the thymus was observed in animals exposed to repeated tube-restraint stress for 10 and 20 consecutive days. The observed changes in the thymus were the same, regardless of the number of days of exposure to stress. These findings provide a more comprehensive view of repeated tube-restraint, with special emphasis on its duration on stress-induced thymus atrophy. The presented findings could serve as a basis for further studies aimed at identifying the mechanisms responsible for the adaptive response of the thymus after repeated exposure to stress. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 175006]http://www.doiserbia.nb.rs/img/doi/0354-4664/2020/0354-46641900060D.pdfimmobilizationphysical restraintthymusproliferationapoptosis |
| spellingShingle | Drljača Jovana N. Vejnović Ana-Marija T. Miljković Dejan M. Popović Milan J. Rakić Dušica B. Sekulić Slobodan R. Čapo Ivan Đ. Petković Branka B. Changes in mouse thymus after exposure to tube-restraint stress Archives of Biological Sciences immobilization physical restraint thymus proliferation apoptosis |
| title | Changes in mouse thymus after exposure to tube-restraint stress |
| title_full | Changes in mouse thymus after exposure to tube-restraint stress |
| title_fullStr | Changes in mouse thymus after exposure to tube-restraint stress |
| title_full_unstemmed | Changes in mouse thymus after exposure to tube-restraint stress |
| title_short | Changes in mouse thymus after exposure to tube-restraint stress |
| title_sort | changes in mouse thymus after exposure to tube restraint stress |
| topic | immobilization physical restraint thymus proliferation apoptosis |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2020/0354-46641900060D.pdf |
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