Vitamin D and hypertension: Prospective study and meta-analysis.
OBJECTIVES:The study sought to determine the link between vitamin D concentrations and incident hypertension in prospective study and meta-analysis. METHODS:The study was embedded in the Kailuan Study, a population-based cohort of adults that contains underground miners. In 2012, we studied 2,456 me...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5373576?pdf=render |
| _version_ | 1828886026155720704 |
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| author | Dan Qi Xiao-Lu Nie Shouling Wu Jun Cai |
| author_facet | Dan Qi Xiao-Lu Nie Shouling Wu Jun Cai |
| author_sort | Dan Qi |
| collection | DOAJ |
| description | OBJECTIVES:The study sought to determine the link between vitamin D concentrations and incident hypertension in prospective study and meta-analysis. METHODS:The study was embedded in the Kailuan Study, a population-based cohort of adults that contains underground miners. In 2012, we studied 2,456 men and women free of prevalent hypertension, age 21 to 67 at baseline. Serum 25-hydroxyvitamin D was measured from previously frozen baseline samples using ELISA (Enzyme-Linked ImmunoadSorbent Assay). We use the logistic regression analysis to estimate the odd radio (ORs) 95% confidence intervals (CIs) for 25-hydroxyvitamin D [25(OH)D] concentrations with incident hypertension. To help place our new data in context, we conducted a systemic review and meta-analysis of previous prospective reports of vitamin D and hypertension. RESULTS:During a median follow-up of 2 years, 42.6% of the cohort (n = 1047) developed hypertension. Compared with the 25-hydroxyvitamin D >30ng/ml, 25-hydroxyvitamin D <20 ng/ml was associated with a greater hypertension risk (OR: 1.225 [95% CI: 1.010 to 1.485] p = 0.04), although the association was attenuated and not statistically significant after adjusting for potential confounders (OR: 1.092 [95% CI: 0.866 to 1.377] p = 0.456). This meta-analysis included seven prospective studies for 53,375 participants using adjusted HR founded a significant association between vitamin D deficiencies and incident hypertension (HRs = 1.235 (95% CI: 1.083 to 1.409, p = 0.002)). CONCLUSION:Lower serum 25-hydroxyvitamin D concentrations were not associated with a greater risk of incident hypertension. More research is needed to further determine the role of 25-hydroxyvitamin D in hypertension prevention and therapy. |
| first_indexed | 2024-12-13T11:37:56Z |
| format | Article |
| id | doaj.art-34b843571f034608a228cb7324b502bd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T11:37:56Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-34b843571f034608a228cb7324b502bd2022-12-21T23:47:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01123e017429810.1371/journal.pone.0174298Vitamin D and hypertension: Prospective study and meta-analysis.Dan QiXiao-Lu NieShouling WuJun CaiOBJECTIVES:The study sought to determine the link between vitamin D concentrations and incident hypertension in prospective study and meta-analysis. METHODS:The study was embedded in the Kailuan Study, a population-based cohort of adults that contains underground miners. In 2012, we studied 2,456 men and women free of prevalent hypertension, age 21 to 67 at baseline. Serum 25-hydroxyvitamin D was measured from previously frozen baseline samples using ELISA (Enzyme-Linked ImmunoadSorbent Assay). We use the logistic regression analysis to estimate the odd radio (ORs) 95% confidence intervals (CIs) for 25-hydroxyvitamin D [25(OH)D] concentrations with incident hypertension. To help place our new data in context, we conducted a systemic review and meta-analysis of previous prospective reports of vitamin D and hypertension. RESULTS:During a median follow-up of 2 years, 42.6% of the cohort (n = 1047) developed hypertension. Compared with the 25-hydroxyvitamin D >30ng/ml, 25-hydroxyvitamin D <20 ng/ml was associated with a greater hypertension risk (OR: 1.225 [95% CI: 1.010 to 1.485] p = 0.04), although the association was attenuated and not statistically significant after adjusting for potential confounders (OR: 1.092 [95% CI: 0.866 to 1.377] p = 0.456). This meta-analysis included seven prospective studies for 53,375 participants using adjusted HR founded a significant association between vitamin D deficiencies and incident hypertension (HRs = 1.235 (95% CI: 1.083 to 1.409, p = 0.002)). CONCLUSION:Lower serum 25-hydroxyvitamin D concentrations were not associated with a greater risk of incident hypertension. More research is needed to further determine the role of 25-hydroxyvitamin D in hypertension prevention and therapy.http://europepmc.org/articles/PMC5373576?pdf=render |
| spellingShingle | Dan Qi Xiao-Lu Nie Shouling Wu Jun Cai Vitamin D and hypertension: Prospective study and meta-analysis. PLoS ONE |
| title | Vitamin D and hypertension: Prospective study and meta-analysis. |
| title_full | Vitamin D and hypertension: Prospective study and meta-analysis. |
| title_fullStr | Vitamin D and hypertension: Prospective study and meta-analysis. |
| title_full_unstemmed | Vitamin D and hypertension: Prospective study and meta-analysis. |
| title_short | Vitamin D and hypertension: Prospective study and meta-analysis. |
| title_sort | vitamin d and hypertension prospective study and meta analysis |
| url | http://europepmc.org/articles/PMC5373576?pdf=render |
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