Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model

Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model

To unravel the failure of remyelination in multiple sclerosis (MS) and to test promising remyelinating treatments, suitable animal models like the well-established cuprizone model are required. However, this model is only standardized in young mice. This does not represent the typical age of MS pati...

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Bibliographic Details
Main Authors: Stefan Gingele, Florian Henkel, Sandra Heckers, Thiemo M. Moellenkamp, Martin W. Hümmert, Thomas Skripuletz, Martin Stangel, Viktoria Gudi
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
multiple sclerosis
cuprizone
age
oligodendrocyte
myelin
demyelination
Online Access:https://www.mdpi.com/2073-4409/9/4/945

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