Induction of Broad and Polyfunctional HIV-1-Specific T Cell Responses by the Multiepitopic Protein TMEP-B Vectored by MVA Virus

Induction of Broad and Polyfunctional HIV-1-Specific T Cell Responses by the Multiepitopic Protein TMEP-B Vectored by MVA Virus

A human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) vaccine able to induce long-lasting immunity remains a major challenge. We previously designed a T cell multiepitopic immunogen including protective conserved epitopes from HIV-1 Gag, Pol and Nef proteins (TMEP-B), that...

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Bibliographic Details
Main Authors: Beatriz Perdiguero, Cristina Sánchez-Corzo, Carlos Oscar S. Sorzano, Pilar Mediavilla, Lidia Saiz, Mariano Esteban, Carmen Elena Gómez
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Vaccines
Subjects:
HIV-1 vaccine
MVA vector
T cell multiepitopes
immunogenicity in mice
T cell responses
Online Access:https://www.mdpi.com/2076-393X/7/3/57

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