Role of autophagy in atherosclerosis: foe or friend?
Abstract Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the engaging different cells from the vascular wall and circulatory cells. Attempts are cu...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-05-01
|
| Series: | Journal of Inflammation |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12950-019-0212-4 |
| _version_ | 1818252133999312896 |
|---|---|
| author | Mehdi Hassanpour Reza Rahbarghazi Mohammad Nouri Nasser Aghamohammadzadeh Nasser Safaei Mahdi Ahmadi |
| author_facet | Mehdi Hassanpour Reza Rahbarghazi Mohammad Nouri Nasser Aghamohammadzadeh Nasser Safaei Mahdi Ahmadi |
| author_sort | Mehdi Hassanpour |
| collection | DOAJ |
| description | Abstract Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the engaging different cells from the vascular wall and circulatory cells. Attempts are currently focused on the detection of cell compensatory mechanisms against atherosclerotic changes to restore cell function and/or postpone severe vasculitis. Autophagy is an intracellular self-digesting process commonly protrudes exhausted organelles and injured cytoplasmic constituents via double-lipid bilayer membrane vesicles out the target cells. Recent investigations point to the critical and defensive role of autophagy in the vascular cells behavioral function such as endothelial cells and smooth muscle cells against different insults. Autophagy response and related effectors could be modulated in the favor to restore cell function and reduce pro-inflammatory status under pathological conditions. In this review, the recent findings were collected regarding the role of autophagy during atherosclerotic changes. We aimed to answer the question of how autophagy stimulation and/or inhibition could provide a promising effect on developing a sophisticated treatment for AS. |
| first_indexed | 2024-12-12T16:19:20Z |
| format | Article |
| id | doaj.art-34ba47efa70c486f837c261240ff2c06 |
| institution | Directory Open Access Journal |
| issn | 1476-9255 |
| language | English |
| last_indexed | 2024-12-12T16:19:20Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Inflammation |
| spelling | doaj.art-34ba47efa70c486f837c261240ff2c062022-12-22T00:19:01ZengBMCJournal of Inflammation1476-92552019-05-0116111010.1186/s12950-019-0212-4Role of autophagy in atherosclerosis: foe or friend?Mehdi Hassanpour0Reza Rahbarghazi1Mohammad Nouri2Nasser Aghamohammadzadeh3Nasser Safaei4Mahdi Ahmadi5Stem Cell And Regenerative Medicine Institute, Tabriz University of Medical SciencesStem Cell Research Center, Tabriz University of Medical SciencesStem Cell Research Center, Tabriz University of Medical SciencesEndocrine Research Center, Tabriz University of Medical SciencesCardiovascular Research Center, Tabriz University of Medical SciencesDepartment of Physiology, Faculty of Medicine, Tabriz University of Medical SciencesAbstract Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the engaging different cells from the vascular wall and circulatory cells. Attempts are currently focused on the detection of cell compensatory mechanisms against atherosclerotic changes to restore cell function and/or postpone severe vasculitis. Autophagy is an intracellular self-digesting process commonly protrudes exhausted organelles and injured cytoplasmic constituents via double-lipid bilayer membrane vesicles out the target cells. Recent investigations point to the critical and defensive role of autophagy in the vascular cells behavioral function such as endothelial cells and smooth muscle cells against different insults. Autophagy response and related effectors could be modulated in the favor to restore cell function and reduce pro-inflammatory status under pathological conditions. In this review, the recent findings were collected regarding the role of autophagy during atherosclerotic changes. We aimed to answer the question of how autophagy stimulation and/or inhibition could provide a promising effect on developing a sophisticated treatment for AS.http://link.springer.com/article/10.1186/s12950-019-0212-4AutophagyASPharmacological intervention |
| spellingShingle | Mehdi Hassanpour Reza Rahbarghazi Mohammad Nouri Nasser Aghamohammadzadeh Nasser Safaei Mahdi Ahmadi Role of autophagy in atherosclerosis: foe or friend? Journal of Inflammation Autophagy AS Pharmacological intervention |
| title | Role of autophagy in atherosclerosis: foe or friend? |
| title_full | Role of autophagy in atherosclerosis: foe or friend? |
| title_fullStr | Role of autophagy in atherosclerosis: foe or friend? |
| title_full_unstemmed | Role of autophagy in atherosclerosis: foe or friend? |
| title_short | Role of autophagy in atherosclerosis: foe or friend? |
| title_sort | role of autophagy in atherosclerosis foe or friend |
| topic | Autophagy AS Pharmacological intervention |
| url | http://link.springer.com/article/10.1186/s12950-019-0212-4 |
| work_keys_str_mv | AT mehdihassanpour roleofautophagyinatherosclerosisfoeorfriend AT rezarahbarghazi roleofautophagyinatherosclerosisfoeorfriend AT mohammadnouri roleofautophagyinatherosclerosisfoeorfriend AT nasseraghamohammadzadeh roleofautophagyinatherosclerosisfoeorfriend AT nassersafaei roleofautophagyinatherosclerosisfoeorfriend AT mahdiahmadi roleofautophagyinatherosclerosisfoeorfriend |