Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy
Abstract Glutamic acid decarboxylase 65 antibodies (anti-GAD65) have been found in patients with late-onset chronic temporal lobe epilepsy (TLE). No prior neuroimaging studies have addressed how they affect hippocampal volume and shape and how they relate to cognitive abnormalities. We aimed to inve...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-89010-z |
| _version_ | 1818430318337589248 |
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| author | Estefanía Conde-Blanco Saül Pascual-Diaz Mar Carreño Emma Muñoz-Moreno José Carlos Pariente Teresa Boget Isabel Manzanares Antonio Donaire María Centeno Francesc Graus Nuria Bargalló |
| author_facet | Estefanía Conde-Blanco Saül Pascual-Diaz Mar Carreño Emma Muñoz-Moreno José Carlos Pariente Teresa Boget Isabel Manzanares Antonio Donaire María Centeno Francesc Graus Nuria Bargalló |
| author_sort | Estefanía Conde-Blanco |
| collection | DOAJ |
| description | Abstract Glutamic acid decarboxylase 65 antibodies (anti-GAD65) have been found in patients with late-onset chronic temporal lobe epilepsy (TLE). No prior neuroimaging studies have addressed how they affect hippocampal volume and shape and how they relate to cognitive abnormalities. We aimed to investigate both brain structure and function in patients with isolated TLE and high anti-GAD65 levels (RIA ≥ 2000 U/ml) compared to 8 non-immune mesial TLE (niTLE) and 8 healthy controls (HC). Hippocampal subfield volume properties were correlated with the duration of the disease and cognitive test scores. The affected hippocampus of GAD-TLE patients showed no volume changes to matched HC whereas niTLE volumes were significantly smaller. Epilepsy duration in GAD-TLE patients correlated negatively with volumes in the presubiculum, subiculum, CA1, CA2–3, CA4, molecular layer and granule cell-molecular layer of the dentate nucleus. We found differences by advanced vertex-wise shape analysis in the anterior hippocampus of the left GAD-TLE compared to HC whereas left niTLE showed bilateral posterior hippocampus deformation. Verbal deficits were similar in GAD-TLE and niTLE but did not correlate to volume changes. These data might suggest a distinct expression of hippocampal structural and functional abnormalities based on the immune response. |
| first_indexed | 2024-12-14T15:31:30Z |
| format | Article |
| id | doaj.art-34ba8eee17874fb7865f98b1bf935d26 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T15:31:30Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-34ba8eee17874fb7865f98b1bf935d262022-12-21T22:55:53ZengNature PortfolioScientific Reports2045-23222021-05-0111111010.1038/s41598-021-89010-zVolumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsyEstefanía Conde-Blanco0Saül Pascual-Diaz1Mar Carreño2Emma Muñoz-Moreno3José Carlos Pariente4Teresa Boget5Isabel Manzanares6Antonio Donaire7María Centeno8Francesc Graus9Nuria Bargalló10Epilepsy Program, Neurology Department, Hospital Clínic de Barcelona, EpiCARE: European Reference Network for Epilepsy, Institut D’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Magnetic Resonance Imaging Core Facility, IDIBAPSEpilepsy Program, Neurology Department, Hospital Clínic de Barcelona, EpiCARE: European Reference Network for Epilepsy, Institut D’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Magnetic Resonance Imaging Core Facility, IDIBAPSMagnetic Resonance Imaging Core Facility, IDIBAPSEpilepsy Program, Neuropsychology, Hospital Clínic de BarcelonaEpilepsy Program, Neurology Department, Hospital Clínic de Barcelona, EpiCARE: European Reference Network for Epilepsy, Institut D’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Epilepsy Program, Neurology Department, Hospital Clínic de Barcelona, EpiCARE: European Reference Network for Epilepsy, Institut D’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Epilepsy Program, Neurology Department, Hospital Clínic de Barcelona, EpiCARE: European Reference Network for Epilepsy, Institut D’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Clinical and Experimental Neuroimmunology Research Team of IDIBAPSMagnetic Resonance Imaging Core Facility, IDIBAPSAbstract Glutamic acid decarboxylase 65 antibodies (anti-GAD65) have been found in patients with late-onset chronic temporal lobe epilepsy (TLE). No prior neuroimaging studies have addressed how they affect hippocampal volume and shape and how they relate to cognitive abnormalities. We aimed to investigate both brain structure and function in patients with isolated TLE and high anti-GAD65 levels (RIA ≥ 2000 U/ml) compared to 8 non-immune mesial TLE (niTLE) and 8 healthy controls (HC). Hippocampal subfield volume properties were correlated with the duration of the disease and cognitive test scores. The affected hippocampus of GAD-TLE patients showed no volume changes to matched HC whereas niTLE volumes were significantly smaller. Epilepsy duration in GAD-TLE patients correlated negatively with volumes in the presubiculum, subiculum, CA1, CA2–3, CA4, molecular layer and granule cell-molecular layer of the dentate nucleus. We found differences by advanced vertex-wise shape analysis in the anterior hippocampus of the left GAD-TLE compared to HC whereas left niTLE showed bilateral posterior hippocampus deformation. Verbal deficits were similar in GAD-TLE and niTLE but did not correlate to volume changes. These data might suggest a distinct expression of hippocampal structural and functional abnormalities based on the immune response.https://doi.org/10.1038/s41598-021-89010-z |
| spellingShingle | Estefanía Conde-Blanco Saül Pascual-Diaz Mar Carreño Emma Muñoz-Moreno José Carlos Pariente Teresa Boget Isabel Manzanares Antonio Donaire María Centeno Francesc Graus Nuria Bargalló Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy Scientific Reports |
| title | Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy |
| title_full | Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy |
| title_fullStr | Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy |
| title_full_unstemmed | Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy |
| title_short | Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy |
| title_sort | volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with gad65 antibodies compared with non immune epilepsy |
| url | https://doi.org/10.1038/s41598-021-89010-z |
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