Analogies between COVID-19 and Preeclampsia: Focus on Therapies
Preeclampsia is an obstetric pathology with striking similarities to COVID-19. The renin-angiotensin system plays a key role in the pathogenesis of both diseases. This report reviews the pharmacological strategies that have been suggested for the prevention and treatment of preeclampsia and that are...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Translational Medicine |
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| Online Access: | https://www.mdpi.com/2673-8937/3/2/15 |
| _version_ | 1797594194021187584 |
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| author | Valentina Giardini Carlo Gambacorti-Passerini Marco Casati Andrea Carrer Patrizia Vergani |
| author_facet | Valentina Giardini Carlo Gambacorti-Passerini Marco Casati Andrea Carrer Patrizia Vergani |
| author_sort | Valentina Giardini |
| collection | DOAJ |
| description | Preeclampsia is an obstetric pathology with striking similarities to COVID-19. The renin-angiotensin system plays a key role in the pathogenesis of both diseases. This report reviews the pharmacological strategies that have been suggested for the prevention and treatment of preeclampsia and that are potentially useful also in the treatment of COVID-19. Of note, both pathologies have in common an Angiotensin II-mediated endothelial dysfunction secondary to an angiogenic imbalance, with effects on vasculature, coagulation, and inflammation. These considerations are drawn from cases of the initial SARS-CoV-2 primary infection and may not apply to more recent SARS-CoV-2 variants or infections after COVID vaccination. The treatment options discussed included albumin infusion, aspirin, corticosteroids, the monoclonal antibody eculizumab, hydroxychloroquine, low molecular weight heparin, magnesium, melatonin, metformin, nitric oxide, proton pump inhibitors, statins, therapeutic apheresis, and vitamin D. |
| first_indexed | 2024-03-11T02:20:10Z |
| format | Article |
| id | doaj.art-34be407c8f484535942205f220d6a996 |
| institution | Directory Open Access Journal |
| issn | 2673-8937 |
| language | English |
| last_indexed | 2024-03-11T02:20:10Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Translational Medicine |
| spelling | doaj.art-34be407c8f484535942205f220d6a9962023-11-18T10:53:39ZengMDPI AGInternational Journal of Translational Medicine2673-89372023-04-013220321610.3390/ijtm3020015Analogies between COVID-19 and Preeclampsia: Focus on TherapiesValentina Giardini0Carlo Gambacorti-Passerini1Marco Casati2Andrea Carrer3Patrizia Vergani4Department of Obstetrics and Gynecology, IRCCS San Gerardo dei Tintori Foundation, University of Milano-Bicocca, 20900 Monza, ItalyHematology Division, IRCCS San Gerardo dei Tintori Foundation, University of Milano-Bicocca, 20900 Monza, ItalyLaboratory Medicine, IRCCS San Gerardo dei Tintori Foundation, University of Milano-Bicocca, 20900 Monza, ItalyHematology Division, IRCCS San Gerardo dei Tintori Foundation, University of Milano-Bicocca, 20900 Monza, ItalyDepartment of Obstetrics and Gynecology, IRCCS San Gerardo dei Tintori Foundation, University of Milano-Bicocca, 20900 Monza, ItalyPreeclampsia is an obstetric pathology with striking similarities to COVID-19. The renin-angiotensin system plays a key role in the pathogenesis of both diseases. This report reviews the pharmacological strategies that have been suggested for the prevention and treatment of preeclampsia and that are potentially useful also in the treatment of COVID-19. Of note, both pathologies have in common an Angiotensin II-mediated endothelial dysfunction secondary to an angiogenic imbalance, with effects on vasculature, coagulation, and inflammation. These considerations are drawn from cases of the initial SARS-CoV-2 primary infection and may not apply to more recent SARS-CoV-2 variants or infections after COVID vaccination. The treatment options discussed included albumin infusion, aspirin, corticosteroids, the monoclonal antibody eculizumab, hydroxychloroquine, low molecular weight heparin, magnesium, melatonin, metformin, nitric oxide, proton pump inhibitors, statins, therapeutic apheresis, and vitamin D.https://www.mdpi.com/2673-8937/3/2/15COVID-19SARS-CoV-2preeclampsiarenin-angiotensin systemangiogenic factorsPlGF |
| spellingShingle | Valentina Giardini Carlo Gambacorti-Passerini Marco Casati Andrea Carrer Patrizia Vergani Analogies between COVID-19 and Preeclampsia: Focus on Therapies International Journal of Translational Medicine COVID-19 SARS-CoV-2 preeclampsia renin-angiotensin system angiogenic factors PlGF |
| title | Analogies between COVID-19 and Preeclampsia: Focus on Therapies |
| title_full | Analogies between COVID-19 and Preeclampsia: Focus on Therapies |
| title_fullStr | Analogies between COVID-19 and Preeclampsia: Focus on Therapies |
| title_full_unstemmed | Analogies between COVID-19 and Preeclampsia: Focus on Therapies |
| title_short | Analogies between COVID-19 and Preeclampsia: Focus on Therapies |
| title_sort | analogies between covid 19 and preeclampsia focus on therapies |
| topic | COVID-19 SARS-CoV-2 preeclampsia renin-angiotensin system angiogenic factors PlGF |
| url | https://www.mdpi.com/2673-8937/3/2/15 |
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