Intricate knots in proteins: Function and evolution.
Our investigation of knotted structures in the Protein Data Bank reveals the most complicated knot discovered to date. We suggest that the occurrence of this knot in a human ubiquitin hydrolase might be related to the role of the enzyme in protein degradation. While knots are usually preserved among...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-09-01
|
| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.0020122 |
| _version_ | 1818348699104837632 |
|---|---|
| author | Peter Virnau Leonid A Mirny Mehran Kardar |
| author_facet | Peter Virnau Leonid A Mirny Mehran Kardar |
| author_sort | Peter Virnau |
| collection | DOAJ |
| description | Our investigation of knotted structures in the Protein Data Bank reveals the most complicated knot discovered to date. We suggest that the occurrence of this knot in a human ubiquitin hydrolase might be related to the role of the enzyme in protein degradation. While knots are usually preserved among homologues, we also identify an exception in a transcarbamylase. This allows us to exemplify the function of knots in proteins and to suggest how they may have been created. |
| first_indexed | 2024-12-13T17:54:12Z |
| format | Article |
| id | doaj.art-34beeee3111a409b9dfa4f68d70163b5 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-13T17:54:12Z |
| publishDate | 2006-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-34beeee3111a409b9dfa4f68d70163b52022-12-21T23:36:25ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582006-09-0129e12210.1371/journal.pcbi.0020122Intricate knots in proteins: Function and evolution.Peter VirnauLeonid A MirnyMehran KardarOur investigation of knotted structures in the Protein Data Bank reveals the most complicated knot discovered to date. We suggest that the occurrence of this knot in a human ubiquitin hydrolase might be related to the role of the enzyme in protein degradation. While knots are usually preserved among homologues, we also identify an exception in a transcarbamylase. This allows us to exemplify the function of knots in proteins and to suggest how they may have been created.https://doi.org/10.1371/journal.pcbi.0020122 |
| spellingShingle | Peter Virnau Leonid A Mirny Mehran Kardar Intricate knots in proteins: Function and evolution. PLoS Computational Biology |
| title | Intricate knots in proteins: Function and evolution. |
| title_full | Intricate knots in proteins: Function and evolution. |
| title_fullStr | Intricate knots in proteins: Function and evolution. |
| title_full_unstemmed | Intricate knots in proteins: Function and evolution. |
| title_short | Intricate knots in proteins: Function and evolution. |
| title_sort | intricate knots in proteins function and evolution |
| url | https://doi.org/10.1371/journal.pcbi.0020122 |
| work_keys_str_mv | AT petervirnau intricateknotsinproteinsfunctionandevolution AT leonidamirny intricateknotsinproteinsfunctionandevolution AT mehrankardar intricateknotsinproteinsfunctionandevolution |