Etoposide Triggers Cellular Senescence by Inducing Multiple Centrosomes and Primary Cilia in Adrenocortical Tumor Cells

Etoposide Triggers Cellular Senescence by Inducing Multiple Centrosomes and Primary Cilia in Adrenocortical Tumor Cells

Etoposide (ETO) has been used in treating adrenocortical tumor (ACT) cells. Our previous study showed that ETO inhibits ACT cell growth. In the present study, we show that ETO treatment at IC50 (10 μM) inhibited ACT cell growth by inducing cellular senescence rather than apoptosis. Several markers o...

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Bibliographic Details
Main Authors: Yen-Ni Teng, Huei-Cih Chang, Yu-Ying Chao, Hui-Ling Cheng, Wei-Chih Lien, Chia-Yih Wang
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
etoposide
centrosome
primary cilia
senescence
autophagy
DNA-PK
Online Access:https://www.mdpi.com/2073-4409/10/6/1466

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