Polyphenols as Promising Drugs against Main Breast Cancer Signatures
Breast cancer is one of the most common neoplasms worldwide, and in spite of clinical and pharmacological advances, it is still a clinical problem, causing morbidity and mortality. On the one hand, breast cancer shares with other neoplasms some molecular signatures such as an imbalanced redox state,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/6/4/88 |
| _version_ | 1797714145557086208 |
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| author | María Losada-Echeberría María Herranz-López Vicente Micol Enrique Barrajón-Catalán |
| author_facet | María Losada-Echeberría María Herranz-López Vicente Micol Enrique Barrajón-Catalán |
| author_sort | María Losada-Echeberría |
| collection | DOAJ |
| description | Breast cancer is one of the most common neoplasms worldwide, and in spite of clinical and pharmacological advances, it is still a clinical problem, causing morbidity and mortality. On the one hand, breast cancer shares with other neoplasms some molecular signatures such as an imbalanced redox state, cell cycle alterations, increased proliferation and an inflammatory status. On the other hand, breast cancer shows differential molecular subtypes that determine its prognosis and treatment. These are characterized mainly by hormone receptors especially estrogen receptors (ERs) and epidermal growth factor receptor 2 (HER2). Tumors with none of these receptors are classified as triple negative breast cancer (TNBC) and are associated with a worse prognosis. The success of treatments partially depends on their specificity and the adequate molecular classification of tumors. New advances in anticancer drug discovery using natural compounds have been made in the last few decades, and polyphenols have emerged as promising molecules. They may act on various molecular targets because of their promiscuous behavior, presenting several physiological effects, some of which confer antitumor activity. This review analyzes the accumulated evidence of the antitumor effects of plant polyphenols on breast cancer, with special attention to their activity on ERs and HER2 targets and also covering different aspects such as redox balance, uncontrolled proliferation and chronic inflammation. |
| first_indexed | 2024-03-12T07:47:36Z |
| format | Article |
| id | doaj.art-34c01e0ab783499482dc5b461c417861 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T07:47:36Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-34c01e0ab783499482dc5b461c4178612023-09-02T20:50:52ZengMDPI AGAntioxidants2076-39212017-11-01648810.3390/antiox6040088antiox6040088Polyphenols as Promising Drugs against Main Breast Cancer SignaturesMaría Losada-Echeberría0María Herranz-López1Vicente Micol2Enrique Barrajón-Catalán3Institute of Molecular and Cell Biology (IBMC), Miguel Hernández University (UMH), Avda. Universidad s/n, Elche 03202, SpainInstitute of Molecular and Cell Biology (IBMC), Miguel Hernández University (UMH), Avda. Universidad s/n, Elche 03202, SpainInstitute of Molecular and Cell Biology (IBMC), Miguel Hernández University (UMH), Avda. Universidad s/n, Elche 03202, SpainInstitute of Molecular and Cell Biology (IBMC), Miguel Hernández University (UMH), Avda. Universidad s/n, Elche 03202, SpainBreast cancer is one of the most common neoplasms worldwide, and in spite of clinical and pharmacological advances, it is still a clinical problem, causing morbidity and mortality. On the one hand, breast cancer shares with other neoplasms some molecular signatures such as an imbalanced redox state, cell cycle alterations, increased proliferation and an inflammatory status. On the other hand, breast cancer shows differential molecular subtypes that determine its prognosis and treatment. These are characterized mainly by hormone receptors especially estrogen receptors (ERs) and epidermal growth factor receptor 2 (HER2). Tumors with none of these receptors are classified as triple negative breast cancer (TNBC) and are associated with a worse prognosis. The success of treatments partially depends on their specificity and the adequate molecular classification of tumors. New advances in anticancer drug discovery using natural compounds have been made in the last few decades, and polyphenols have emerged as promising molecules. They may act on various molecular targets because of their promiscuous behavior, presenting several physiological effects, some of which confer antitumor activity. This review analyzes the accumulated evidence of the antitumor effects of plant polyphenols on breast cancer, with special attention to their activity on ERs and HER2 targets and also covering different aspects such as redox balance, uncontrolled proliferation and chronic inflammation.https://www.mdpi.com/2076-3921/6/4/88breast cancerpolyphenolsluminalTNBCredox balanceapoptosisautophagyinflammationERHER2 |
| spellingShingle | María Losada-Echeberría María Herranz-López Vicente Micol Enrique Barrajón-Catalán Polyphenols as Promising Drugs against Main Breast Cancer Signatures Antioxidants breast cancer polyphenols luminal TNBC redox balance apoptosis autophagy inflammation ER HER2 |
| title | Polyphenols as Promising Drugs against Main Breast Cancer Signatures |
| title_full | Polyphenols as Promising Drugs against Main Breast Cancer Signatures |
| title_fullStr | Polyphenols as Promising Drugs against Main Breast Cancer Signatures |
| title_full_unstemmed | Polyphenols as Promising Drugs against Main Breast Cancer Signatures |
| title_short | Polyphenols as Promising Drugs against Main Breast Cancer Signatures |
| title_sort | polyphenols as promising drugs against main breast cancer signatures |
| topic | breast cancer polyphenols luminal TNBC redox balance apoptosis autophagy inflammation ER HER2 |
| url | https://www.mdpi.com/2076-3921/6/4/88 |
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