The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded
<p>Abstract</p> <p>The vascular endothelial basement membrane and extra cellular matrix is a compilation of different macromolecules organized by physical entanglements, opposing ionic charges, chemical covalent bonding, and cross-linking into a biomechanically active polymer. Thes...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2005-06-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://www.cardiab.com/content/4/1/9 |
| _version_ | 1818273328270409728 |
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| author | Tyagi Suresh C Sowers James R Hayden Melvin R |
| author_facet | Tyagi Suresh C Sowers James R Hayden Melvin R |
| author_sort | Tyagi Suresh C |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The vascular endothelial basement membrane and extra cellular matrix is a compilation of different macromolecules organized by physical entanglements, opposing ionic charges, chemical covalent bonding, and cross-linking into a biomechanically active polymer. These matrices provide a gel-like form and scaffolding structure with regional tensile strength provided by collagens, elasticity by elastins, adhesiveness by structural glycoproteins, compressibility by proteoglycans – hyaluronans, and communicability by a family of integrins, which exchanges information between cells and between cells and the extracellular matrix of vascular tissues.</p> <p>Each component of the extracellular matrix and specifically the capillary basement membrane possesses unique structural properties and interactions with one another, which determine the separate and combined roles in the multiple diabetic complications or diabetic opathies.</p> <p>Metabolic syndrome, prediabetes, type 2 diabetes mellitus, and their parallel companion (atheroscleropathy) are associated with multiple metabolic toxicities and chronic injurious stimuli. The adaptable quality of a matrix or form genetically preloaded with the necessary information to communicate and respond to an ever-changing environment, which supports the interstitium, capillary and arterial vessel wall is individually examined.</p> |
| first_indexed | 2024-12-12T21:56:13Z |
| format | Article |
| id | doaj.art-34c02a16c7e54979bfd1a08d6441ca78 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-12T21:56:13Z |
| publishDate | 2005-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-34c02a16c7e54979bfd1a08d6441ca782022-12-22T00:10:39ZengBMCCardiovascular Diabetology1475-28402005-06-0141910.1186/1475-2840-4-9The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloadedTyagi Suresh CSowers James RHayden Melvin R<p>Abstract</p> <p>The vascular endothelial basement membrane and extra cellular matrix is a compilation of different macromolecules organized by physical entanglements, opposing ionic charges, chemical covalent bonding, and cross-linking into a biomechanically active polymer. These matrices provide a gel-like form and scaffolding structure with regional tensile strength provided by collagens, elasticity by elastins, adhesiveness by structural glycoproteins, compressibility by proteoglycans – hyaluronans, and communicability by a family of integrins, which exchanges information between cells and between cells and the extracellular matrix of vascular tissues.</p> <p>Each component of the extracellular matrix and specifically the capillary basement membrane possesses unique structural properties and interactions with one another, which determine the separate and combined roles in the multiple diabetic complications or diabetic opathies.</p> <p>Metabolic syndrome, prediabetes, type 2 diabetes mellitus, and their parallel companion (atheroscleropathy) are associated with multiple metabolic toxicities and chronic injurious stimuli. The adaptable quality of a matrix or form genetically preloaded with the necessary information to communicate and respond to an ever-changing environment, which supports the interstitium, capillary and arterial vessel wall is individually examined.</p>http://www.cardiab.com/content/4/1/9AtherosclerosisCollagenelastinproteoglycanstructural glycoproteinIntegrinoxidative stressredox stressMMPTIMPremodeling |
| spellingShingle | Tyagi Suresh C Sowers James R Hayden Melvin R The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded Cardiovascular Diabetology Atherosclerosis Collagen elastin proteoglycan structural glycoprotein Integrin oxidative stress redox stress MMP TIMP remodeling |
| title | The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded |
| title_full | The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded |
| title_fullStr | The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded |
| title_full_unstemmed | The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded |
| title_short | The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded |
| title_sort | central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes the matrix preloaded |
| topic | Atherosclerosis Collagen elastin proteoglycan structural glycoprotein Integrin oxidative stress redox stress MMP TIMP remodeling |
| url | http://www.cardiab.com/content/4/1/9 |
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