Heart rate variability in hyperthyroidism on sub Saharan African patients: a case–control study
Abstract Objective We aimed to determine heart rate variability in freshly diagnosed untreated hyperthyroidism patients. We enrolled 10 patients (9 females) and 10 matched controls for sex and age. Each eligible patient underwent five different tests according to Ewing battery tests for cardiac auto...
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-018-3922-4 |
| _version_ | 1818559057206706176 |
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| author | Eliane Ngassam Marcel Azabji-Kenfack Aurel T. Tankeu Liliane Mfeukeu-Kuate Chris-Nadège Nganou-Gnindjio Camille Mba Jean Claude Katte Mesmin Y. Dehayem Jean Claude Mbanya Eugène Sobngwi |
| author_facet | Eliane Ngassam Marcel Azabji-Kenfack Aurel T. Tankeu Liliane Mfeukeu-Kuate Chris-Nadège Nganou-Gnindjio Camille Mba Jean Claude Katte Mesmin Y. Dehayem Jean Claude Mbanya Eugène Sobngwi |
| author_sort | Eliane Ngassam |
| collection | DOAJ |
| description | Abstract Objective We aimed to determine heart rate variability in freshly diagnosed untreated hyperthyroidism patients. We enrolled 10 patients (9 females) and 10 matched controls for sex and age. Each eligible patient underwent five different tests according to Ewing battery tests for cardiac autonomic dysfunction assessment. HRV was assessed during each maneuver and on 24 h using a continuous electrocardiogram with automatic estimation of SDNN, RMSSD, LF HF and HF/LH ratio. Results of tests were compared between hyperthyroidism patients and matched controls using the non-parametric test of Mann–Whitney. Results Heart rate was significantly higher in patients with thyrotoxicosis (82.91 ± 10.99 vs 67.04 ± 6.80; 0.006) compared to their controls. On time-domain analysis, there was a trend towards reduction in SDNN (39.52 vs. 63.75; p = 0.2) as well as the RMSSD (30.44 vs 64.03; p = 0.09) in patients with hyperthyroidism. The frequency-domain analysis showed non-significant higher values for the LF (43.87 vs 38.85 ± 12.85; p = 0.8) and lower for the HF (32.54 vs 43.39; p = 0.3). Test’s results were mostly impaired in hyperthyroid patients and all patients presented abnormal results for parasympathetic activity. Untreated and recently diagnosed hyperthyroidism is associated to an altered parasympathetic activity in sub Saharan African patients. |
| first_indexed | 2024-12-14T00:20:23Z |
| format | Article |
| id | doaj.art-34c1ae74c1464275b8c1aad745eee66f |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-14T00:20:23Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-34c1ae74c1464275b8c1aad745eee66f2022-12-21T23:25:15ZengBMCBMC Research Notes1756-05002018-11-011111510.1186/s13104-018-3922-4Heart rate variability in hyperthyroidism on sub Saharan African patients: a case–control studyEliane Ngassam0Marcel Azabji-Kenfack1Aurel T. Tankeu2Liliane Mfeukeu-Kuate3Chris-Nadège Nganou-Gnindjio4Camille Mba5Jean Claude Katte6Mesmin Y. Dehayem7Jean Claude Mbanya8Eugène Sobngwi9National Obesity Center, Yaoundé Central HospitalFaculty of Medicine and Biomedical Sciences, University of Yaoundé 1National Obesity Center, Yaoundé Central HospitalNational Obesity Center, Yaoundé Central HospitalNational Obesity Center, Yaoundé Central HospitalNational Obesity Center, Yaoundé Central HospitalNational Obesity Center, Yaoundé Central HospitalNational Obesity Center, Yaoundé Central HospitalNational Obesity Center, Yaoundé Central HospitalNational Obesity Center, Yaoundé Central HospitalAbstract Objective We aimed to determine heart rate variability in freshly diagnosed untreated hyperthyroidism patients. We enrolled 10 patients (9 females) and 10 matched controls for sex and age. Each eligible patient underwent five different tests according to Ewing battery tests for cardiac autonomic dysfunction assessment. HRV was assessed during each maneuver and on 24 h using a continuous electrocardiogram with automatic estimation of SDNN, RMSSD, LF HF and HF/LH ratio. Results of tests were compared between hyperthyroidism patients and matched controls using the non-parametric test of Mann–Whitney. Results Heart rate was significantly higher in patients with thyrotoxicosis (82.91 ± 10.99 vs 67.04 ± 6.80; 0.006) compared to their controls. On time-domain analysis, there was a trend towards reduction in SDNN (39.52 vs. 63.75; p = 0.2) as well as the RMSSD (30.44 vs 64.03; p = 0.09) in patients with hyperthyroidism. The frequency-domain analysis showed non-significant higher values for the LF (43.87 vs 38.85 ± 12.85; p = 0.8) and lower for the HF (32.54 vs 43.39; p = 0.3). Test’s results were mostly impaired in hyperthyroid patients and all patients presented abnormal results for parasympathetic activity. Untreated and recently diagnosed hyperthyroidism is associated to an altered parasympathetic activity in sub Saharan African patients.http://link.springer.com/article/10.1186/s13104-018-3922-4HyperthyroidismHeart rate variabilityShort-termAfrica |
| spellingShingle | Eliane Ngassam Marcel Azabji-Kenfack Aurel T. Tankeu Liliane Mfeukeu-Kuate Chris-Nadège Nganou-Gnindjio Camille Mba Jean Claude Katte Mesmin Y. Dehayem Jean Claude Mbanya Eugène Sobngwi Heart rate variability in hyperthyroidism on sub Saharan African patients: a case–control study BMC Research Notes Hyperthyroidism Heart rate variability Short-term Africa |
| title | Heart rate variability in hyperthyroidism on sub Saharan African patients: a case–control study |
| title_full | Heart rate variability in hyperthyroidism on sub Saharan African patients: a case–control study |
| title_fullStr | Heart rate variability in hyperthyroidism on sub Saharan African patients: a case–control study |
| title_full_unstemmed | Heart rate variability in hyperthyroidism on sub Saharan African patients: a case–control study |
| title_short | Heart rate variability in hyperthyroidism on sub Saharan African patients: a case–control study |
| title_sort | heart rate variability in hyperthyroidism on sub saharan african patients a case control study |
| topic | Hyperthyroidism Heart rate variability Short-term Africa |
| url | http://link.springer.com/article/10.1186/s13104-018-3922-4 |
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