Prevalence and effects of sleep-disordered breathing on middle-aged patients with sedative-free generalized anxiety disorder: A prospective case-control study
ObjectiveGeneralized anxiety disorder (GAD) and sleep-disordered breathing (SDB) share similar symptoms, such as poor sleep quality, irritability, and poor concentration during daily activities. This study aims to investigate the proportion of undiagnosed SDB and its impacts on anxiety severity and...
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1067437/full |
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| author | Tien-Yu Chen Tien-Yu Chen Tien-Yu Chen Yen-Ying Kung Yen-Ying Kung Yen-Ying Kung Hsiao-Ching Lai Li-Ang Lee Li-Ang Lee I-An Jen I-An Jen I-An Jen Hsin-An Chang Chia-Yu Liu Terry B. J. Kuo Terry B. J. Kuo Terry B. J. Kuo Terry B. J. Kuo Cheryl C. H. Yang Cheryl C. H. Yang Cheryl C. H. Yang |
| author_facet | Tien-Yu Chen Tien-Yu Chen Tien-Yu Chen Yen-Ying Kung Yen-Ying Kung Yen-Ying Kung Hsiao-Ching Lai Li-Ang Lee Li-Ang Lee I-An Jen I-An Jen I-An Jen Hsin-An Chang Chia-Yu Liu Terry B. J. Kuo Terry B. J. Kuo Terry B. J. Kuo Terry B. J. Kuo Cheryl C. H. Yang Cheryl C. H. Yang Cheryl C. H. Yang |
| author_sort | Tien-Yu Chen |
| collection | DOAJ |
| description | ObjectiveGeneralized anxiety disorder (GAD) and sleep-disordered breathing (SDB) share similar symptoms, such as poor sleep quality, irritability, and poor concentration during daily activities. This study aims to investigate the proportion of undiagnosed SDB and its impacts on anxiety severity and autonomic function in newly diagnosed, sedative-free GAD patients.MethodsThis prospective case-control study included newly diagnosed GAD patients and control participants with matched age, sex, and body mass index (BMI) in Taiwan. All participants completed questionnaires for sleep and mood symptoms and a resting 5-min heart rate variability (HRV) examination during enrollment. The participants also used a home sleep apnea test to detect SDB. An oxygen desaturation index (ODI) ≥ 5 was considered indicative of SDB.ResultsIn total, 56 controls and 47 newly diagnosed GAD participants (mean age 55.31 ± 12.36 years, mean BMI 23.41 ± 3.42 kg/m2) were included. There was no significant difference in the proportion of undiagnosed SDB in the control and sedative-free GAD groups (46.43 vs. 51.06%). Sedative-free GAD patients with SDB scored significantly higher on Beck Anxiety Inventory (23.83 ± 11.54) than those without SDB (16.52 ± 10.61) (p < 0.001). Both control and sedative-free GAD groups with SDB had worse global autonomic function than the control group without SDB, as evidenced by the HRV results (p < 0.05 for all).ConclusionAverage age 55 years and mean BMI 23 kg/m2 patients with GAD and matched controls had an undiagnosed SDB prevalence of approximately 50%. SDB correlated with worsening anxiety severity and reduced cardiac autonomic function. Moreover, age and BMI were considered major risk factors for predicting undiagnosed SDB. |
| first_indexed | 2024-04-10T23:53:14Z |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-34c50f97b5f24fddb6dbc2cc9ca98f932023-01-10T14:47:46ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-01-011310.3389/fpsyt.2022.10674371067437Prevalence and effects of sleep-disordered breathing on middle-aged patients with sedative-free generalized anxiety disorder: A prospective case-control studyTien-Yu Chen0Tien-Yu Chen1Tien-Yu Chen2Yen-Ying Kung3Yen-Ying Kung4Yen-Ying Kung5Hsiao-Ching Lai6Li-Ang Lee7Li-Ang Lee8I-An Jen9I-An Jen10I-An Jen11Hsin-An Chang12Chia-Yu Liu13Terry B. J. Kuo14Terry B. J. Kuo15Terry B. J. Kuo16Terry B. J. Kuo17Cheryl C. H. Yang18Cheryl C. H. Yang19Cheryl C. H. Yang20Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanSleep Research Center, National Yang Ming Chiao Tung University, Taipei, TaiwanSchool of Medicine, Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCenter for Traditional Medicine, Taipei Veterans General Hospital, Taipei, TaiwanFaculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanInstitute of Brain Science, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Otorhinolaryngology, Head and Neck Surgery, Sleep Center, Linkou Chang Gung Memorial Hospital, Taoyuan, TaiwanInstitute of Brain Science, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanDepartment of Public Health, College of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanDepartment of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, TaiwanInstitute of Brain Science, National Yang Ming Chiao Tung University, Taipei, TaiwanSleep Research Center, National Yang Ming Chiao Tung University, Taipei, TaiwanTsoutun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan0Clinical Research Center, Taoyuan Psychiatric Center, Ministry of Health and Welfare, Taoyuan, TaiwanInstitute of Brain Science, National Yang Ming Chiao Tung University, Taipei, TaiwanSleep Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan1Brain Research Center, National Yang Ming Chiao Tung University, Taipei, TaiwanObjectiveGeneralized anxiety disorder (GAD) and sleep-disordered breathing (SDB) share similar symptoms, such as poor sleep quality, irritability, and poor concentration during daily activities. This study aims to investigate the proportion of undiagnosed SDB and its impacts on anxiety severity and autonomic function in newly diagnosed, sedative-free GAD patients.MethodsThis prospective case-control study included newly diagnosed GAD patients and control participants with matched age, sex, and body mass index (BMI) in Taiwan. All participants completed questionnaires for sleep and mood symptoms and a resting 5-min heart rate variability (HRV) examination during enrollment. The participants also used a home sleep apnea test to detect SDB. An oxygen desaturation index (ODI) ≥ 5 was considered indicative of SDB.ResultsIn total, 56 controls and 47 newly diagnosed GAD participants (mean age 55.31 ± 12.36 years, mean BMI 23.41 ± 3.42 kg/m2) were included. There was no significant difference in the proportion of undiagnosed SDB in the control and sedative-free GAD groups (46.43 vs. 51.06%). Sedative-free GAD patients with SDB scored significantly higher on Beck Anxiety Inventory (23.83 ± 11.54) than those without SDB (16.52 ± 10.61) (p < 0.001). Both control and sedative-free GAD groups with SDB had worse global autonomic function than the control group without SDB, as evidenced by the HRV results (p < 0.05 for all).ConclusionAverage age 55 years and mean BMI 23 kg/m2 patients with GAD and matched controls had an undiagnosed SDB prevalence of approximately 50%. SDB correlated with worsening anxiety severity and reduced cardiac autonomic function. Moreover, age and BMI were considered major risk factors for predicting undiagnosed SDB.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1067437/fullgeneralized anxiety disordersleep-disordered breathingheart rate variabilityhome sleep apnea testautonomic function |
| spellingShingle | Tien-Yu Chen Tien-Yu Chen Tien-Yu Chen Yen-Ying Kung Yen-Ying Kung Yen-Ying Kung Hsiao-Ching Lai Li-Ang Lee Li-Ang Lee I-An Jen I-An Jen I-An Jen Hsin-An Chang Chia-Yu Liu Terry B. J. Kuo Terry B. J. Kuo Terry B. J. Kuo Terry B. J. Kuo Cheryl C. H. Yang Cheryl C. H. Yang Cheryl C. H. Yang Prevalence and effects of sleep-disordered breathing on middle-aged patients with sedative-free generalized anxiety disorder: A prospective case-control study Frontiers in Psychiatry generalized anxiety disorder sleep-disordered breathing heart rate variability home sleep apnea test autonomic function |
| title | Prevalence and effects of sleep-disordered breathing on middle-aged patients with sedative-free generalized anxiety disorder: A prospective case-control study |
| title_full | Prevalence and effects of sleep-disordered breathing on middle-aged patients with sedative-free generalized anxiety disorder: A prospective case-control study |
| title_fullStr | Prevalence and effects of sleep-disordered breathing on middle-aged patients with sedative-free generalized anxiety disorder: A prospective case-control study |
| title_full_unstemmed | Prevalence and effects of sleep-disordered breathing on middle-aged patients with sedative-free generalized anxiety disorder: A prospective case-control study |
| title_short | Prevalence and effects of sleep-disordered breathing on middle-aged patients with sedative-free generalized anxiety disorder: A prospective case-control study |
| title_sort | prevalence and effects of sleep disordered breathing on middle aged patients with sedative free generalized anxiety disorder a prospective case control study |
| topic | generalized anxiety disorder sleep-disordered breathing heart rate variability home sleep apnea test autonomic function |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1067437/full |
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