Inspiratory muscle weakness contributes to exertional dyspnea in chronic thromboembolic pulmonary hypertension.
Determination of potentially-reversible factors contributing to exertional dyspnea remains an unmet clinical need in chronic thromboembolic pulmonary hypertension (CTEPH). Therefore, we aimed to evaluate the influence of inspiratory muscle weakness (IMW) on exercise capacity and dyspnea during effor...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6160017?pdf=render |
| _version_ | 1798046447071920128 |
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| author | João Victor Rolim Jaquelina Sonoe Ota-Arakaki Eloara V M Ferreira Gabriela A M Figliolino Ivan Ivanaga Elaine Brito Vieira Angelo X C Fonseca Carolina M S Messina Camila Melo Costa J Alberto Neder Luiz Eduardo Nery Roberta Pulcheri Ramos |
| author_facet | João Victor Rolim Jaquelina Sonoe Ota-Arakaki Eloara V M Ferreira Gabriela A M Figliolino Ivan Ivanaga Elaine Brito Vieira Angelo X C Fonseca Carolina M S Messina Camila Melo Costa J Alberto Neder Luiz Eduardo Nery Roberta Pulcheri Ramos |
| author_sort | João Victor Rolim |
| collection | DOAJ |
| description | Determination of potentially-reversible factors contributing to exertional dyspnea remains an unmet clinical need in chronic thromboembolic pulmonary hypertension (CTEPH). Therefore, we aimed to evaluate the influence of inspiratory muscle weakness (IMW) on exercise capacity and dyspnea during effort in patients with CTEPH. We performed a prospective cross-sectional study that included thirty-nine consecutive patients with CTEPH (48 ± 15 yrs, 61% female) confirmed by right heart catheterization that underwent an incremental cardiopulmonary exercise test, 6-minute walk test and maximum inspiratory pressure (MIP) measurement. MIP < 70%pred was found in 46% of patients. On a multiple linear regression analysis, MIP was independently associated with 6MWD and [Formula: see text]. Patients with MIP < 70% presented greater [Formula: see text] than those with MIP ≥ 70%. Additionally, they also presented stronger sensations of dyspnea throughout exercise, even when adjusted for ventilation. At rest and at different levels of exercise, mean inspiratory flow (VT/TI) was significantly higher in patients with MIP < 70%. In conclusion, IMW is associated with a rapid increase of dyspnea, higher inspiratory load and poor exercise capacity in patients with CTEPH. |
| first_indexed | 2024-04-11T23:37:46Z |
| format | Article |
| id | doaj.art-34c53c2cff2f44028c0764a7c80f397a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T23:37:46Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-34c53c2cff2f44028c0764a7c80f397a2022-12-22T03:56:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01139e020407210.1371/journal.pone.0204072Inspiratory muscle weakness contributes to exertional dyspnea in chronic thromboembolic pulmonary hypertension.João Victor RolimJaquelina Sonoe Ota-ArakakiEloara V M FerreiraGabriela A M FigliolinoIvan IvanagaElaine Brito VieiraAngelo X C FonsecaCarolina M S MessinaCamila Melo CostaJ Alberto NederLuiz Eduardo NeryRoberta Pulcheri RamosDetermination of potentially-reversible factors contributing to exertional dyspnea remains an unmet clinical need in chronic thromboembolic pulmonary hypertension (CTEPH). Therefore, we aimed to evaluate the influence of inspiratory muscle weakness (IMW) on exercise capacity and dyspnea during effort in patients with CTEPH. We performed a prospective cross-sectional study that included thirty-nine consecutive patients with CTEPH (48 ± 15 yrs, 61% female) confirmed by right heart catheterization that underwent an incremental cardiopulmonary exercise test, 6-minute walk test and maximum inspiratory pressure (MIP) measurement. MIP < 70%pred was found in 46% of patients. On a multiple linear regression analysis, MIP was independently associated with 6MWD and [Formula: see text]. Patients with MIP < 70% presented greater [Formula: see text] than those with MIP ≥ 70%. Additionally, they also presented stronger sensations of dyspnea throughout exercise, even when adjusted for ventilation. At rest and at different levels of exercise, mean inspiratory flow (VT/TI) was significantly higher in patients with MIP < 70%. In conclusion, IMW is associated with a rapid increase of dyspnea, higher inspiratory load and poor exercise capacity in patients with CTEPH.http://europepmc.org/articles/PMC6160017?pdf=render |
| spellingShingle | João Victor Rolim Jaquelina Sonoe Ota-Arakaki Eloara V M Ferreira Gabriela A M Figliolino Ivan Ivanaga Elaine Brito Vieira Angelo X C Fonseca Carolina M S Messina Camila Melo Costa J Alberto Neder Luiz Eduardo Nery Roberta Pulcheri Ramos Inspiratory muscle weakness contributes to exertional dyspnea in chronic thromboembolic pulmonary hypertension. PLoS ONE |
| title | Inspiratory muscle weakness contributes to exertional dyspnea in chronic thromboembolic pulmonary hypertension. |
| title_full | Inspiratory muscle weakness contributes to exertional dyspnea in chronic thromboembolic pulmonary hypertension. |
| title_fullStr | Inspiratory muscle weakness contributes to exertional dyspnea in chronic thromboembolic pulmonary hypertension. |
| title_full_unstemmed | Inspiratory muscle weakness contributes to exertional dyspnea in chronic thromboembolic pulmonary hypertension. |
| title_short | Inspiratory muscle weakness contributes to exertional dyspnea in chronic thromboembolic pulmonary hypertension. |
| title_sort | inspiratory muscle weakness contributes to exertional dyspnea in chronic thromboembolic pulmonary hypertension |
| url | http://europepmc.org/articles/PMC6160017?pdf=render |
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