Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3

Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3

The breakdown of the intestinal epithelial barrier and subsequent increase in intestinal permeability can lead to systemic inflammatory diseases and multiple-organ failure. Nutrition impacts the intestinal barrier, with dietary components such as gluten increasing permeability. Artificial sweeteners...

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Bibliographic Details
Main Authors: Aparna Shil, Oluwatobi Olusanya, Zaynub Ghufoor, Benjamin Forson, Joanne Marks, Havovi Chichger
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Nutrients
Subjects:
intestinal epithelium
permeability
sweeteners
claudin
Caco-2
Online Access:https://www.mdpi.com/2072-6643/12/6/1862

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