Relationship between small dense low-density lipoprotein cholesterol with carotid plaque in Chinese individuals with abnormal carotid artery intima-media thickness
Abstract Aim To investigate the relationship of small dense low-density lipoprotein cholesterol (sdLDL-C) to carotid artery intima-media thickness (CA-IMT) and carotid plaque (CAP) in Chinese general population, and to evaluate whether sdLDL-C could be an independent risk factor for individuals with...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-021-02023-4 |
| _version_ | 1818722269611950080 |
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| author | Fang Liu Zheng Wang Xia Cao Yingxia Pan Erqiang Zhang Jiahuan Zhou Lina Zheng |
| author_facet | Fang Liu Zheng Wang Xia Cao Yingxia Pan Erqiang Zhang Jiahuan Zhou Lina Zheng |
| author_sort | Fang Liu |
| collection | DOAJ |
| description | Abstract Aim To investigate the relationship of small dense low-density lipoprotein cholesterol (sdLDL-C) to carotid artery intima-media thickness (CA-IMT) and carotid plaque (CAP) in Chinese general population, and to evaluate whether sdLDL-C could be an independent risk factor for individuals with subclinical atherosclerosis. Methods A total of 729 subjects were randomly collected from consecutive individuals from April 2019 to April 2020 for an annual health checkup. CA-IMT > 1.0 mm was defined as abnormal IMT. Plaque stability was measured by ultrasound examination based on the property of the echo. And sdLDL-C levels were detected by LipoPrint system. Multivariate logistic regression analysis was performed to identify factors associated with CA-IMT and carotid plaque. Results The abnormal IMT group had significantly higher sdLDL-C levels than control group (p < 0.0001). And sdLDL-C levels were significantly positively correlated with IMT value (r = 0.1396, p = 0.0021) and presence of carotid plaque (r = 0.14, p = 0.002) in the subjects with abnormal IMT. In addition, subjects with higher levels of sdLDL-C (r = 0.11, p = 0.035) tended to have unstable CAP. After adjustment for age, gender and blood glucose, sdLDL-C level was an independent risk factor of the presence of CAP (OR = 1.59, 95% CI: 1.02–1.83, p = 0.034) in subjects with abnormal IMT. Conclusion SdLDL-C is an independent risk factor of the occurrence of CAP in the Chinese subjects with abnormal IMT. Our findings provide supporting evidence that sdLDL-C might be an alternative way to predict CVD in early stage. |
| first_indexed | 2024-12-17T20:51:57Z |
| format | Article |
| id | doaj.art-34c61b1db31547568efb4e0503199303 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-17T20:51:57Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-34c61b1db31547568efb4e05031993032022-12-21T21:32:59ZengBMCBMC Cardiovascular Disorders1471-22612021-04-0121111410.1186/s12872-021-02023-4Relationship between small dense low-density lipoprotein cholesterol with carotid plaque in Chinese individuals with abnormal carotid artery intima-media thicknessFang Liu0Zheng Wang1Xia Cao2Yingxia Pan3Erqiang Zhang4Jiahuan Zhou5Lina Zheng6Health Management Centre, Kaifeng Central HospitalHealth Management Centre, Kaifeng Central HospitalHealth Management Centre, Kaifeng Central HospitalShanghai Zhangjiang Institue of Medical Innovation, Shanghai Biotecan Pharmaceuticals Co., LtdShanghai Zhangjiang Institue of Medical Innovation, Shanghai Biotecan Pharmaceuticals Co., LtdShanghai Zhangjiang Institue of Medical Innovation, Shanghai Biotecan Pharmaceuticals Co., LtdHealth Management Centre, Kaifeng Central HospitalAbstract Aim To investigate the relationship of small dense low-density lipoprotein cholesterol (sdLDL-C) to carotid artery intima-media thickness (CA-IMT) and carotid plaque (CAP) in Chinese general population, and to evaluate whether sdLDL-C could be an independent risk factor for individuals with subclinical atherosclerosis. Methods A total of 729 subjects were randomly collected from consecutive individuals from April 2019 to April 2020 for an annual health checkup. CA-IMT > 1.0 mm was defined as abnormal IMT. Plaque stability was measured by ultrasound examination based on the property of the echo. And sdLDL-C levels were detected by LipoPrint system. Multivariate logistic regression analysis was performed to identify factors associated with CA-IMT and carotid plaque. Results The abnormal IMT group had significantly higher sdLDL-C levels than control group (p < 0.0001). And sdLDL-C levels were significantly positively correlated with IMT value (r = 0.1396, p = 0.0021) and presence of carotid plaque (r = 0.14, p = 0.002) in the subjects with abnormal IMT. In addition, subjects with higher levels of sdLDL-C (r = 0.11, p = 0.035) tended to have unstable CAP. After adjustment for age, gender and blood glucose, sdLDL-C level was an independent risk factor of the presence of CAP (OR = 1.59, 95% CI: 1.02–1.83, p = 0.034) in subjects with abnormal IMT. Conclusion SdLDL-C is an independent risk factor of the occurrence of CAP in the Chinese subjects with abnormal IMT. Our findings provide supporting evidence that sdLDL-C might be an alternative way to predict CVD in early stage.https://doi.org/10.1186/s12872-021-02023-4Small dense low-density lipoprotein cholesterolIntima media thicknessCarotid plaqueAtherosclerosis |
| spellingShingle | Fang Liu Zheng Wang Xia Cao Yingxia Pan Erqiang Zhang Jiahuan Zhou Lina Zheng Relationship between small dense low-density lipoprotein cholesterol with carotid plaque in Chinese individuals with abnormal carotid artery intima-media thickness BMC Cardiovascular Disorders Small dense low-density lipoprotein cholesterol Intima media thickness Carotid plaque Atherosclerosis |
| title | Relationship between small dense low-density lipoprotein cholesterol with carotid plaque in Chinese individuals with abnormal carotid artery intima-media thickness |
| title_full | Relationship between small dense low-density lipoprotein cholesterol with carotid plaque in Chinese individuals with abnormal carotid artery intima-media thickness |
| title_fullStr | Relationship between small dense low-density lipoprotein cholesterol with carotid plaque in Chinese individuals with abnormal carotid artery intima-media thickness |
| title_full_unstemmed | Relationship between small dense low-density lipoprotein cholesterol with carotid plaque in Chinese individuals with abnormal carotid artery intima-media thickness |
| title_short | Relationship between small dense low-density lipoprotein cholesterol with carotid plaque in Chinese individuals with abnormal carotid artery intima-media thickness |
| title_sort | relationship between small dense low density lipoprotein cholesterol with carotid plaque in chinese individuals with abnormal carotid artery intima media thickness |
| topic | Small dense low-density lipoprotein cholesterol Intima media thickness Carotid plaque Atherosclerosis |
| url | https://doi.org/10.1186/s12872-021-02023-4 |
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