Immune-related mechanisms and immunotherapy in extragonadal germ cell tumors
Purpose of reviewExtragonadal germ cell tumors (EGCTs) are relatively rare tumors, accounting for 1%–5% of all GCTs. In this review, we summarize the current research progress regarding the pathogenesis, diagnosis, and treatment of EGCTs from an immunology perspective.Recent findingsThe histological...
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Format: | Article |
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Frontiers Media S.A.
2023-04-01
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Series: | Frontiers in Immunology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145788/full |
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author | Weigang Xiu Jiyun Pang Jiyun Pang Yang Hu Huashan Shi |
author_facet | Weigang Xiu Jiyun Pang Jiyun Pang Yang Hu Huashan Shi |
author_sort | Weigang Xiu |
collection | DOAJ |
description | Purpose of reviewExtragonadal germ cell tumors (EGCTs) are relatively rare tumors, accounting for 1%–5% of all GCTs. In this review, we summarize the current research progress regarding the pathogenesis, diagnosis, and treatment of EGCTs from an immunology perspective.Recent findingsThe histological origin of EGCTs is related to a gonadal origin, but they are located outside the gonad. They show great variation in morphology and can occur in the cranium, mediastinum, sacrococcygeal bone, and other areas. The pathogenesis of EGCTs is poorly understood, and their differential diagnosis is extensive and challenging. EGCT behavior varies greatly according to patient age, histological subtype, and clinical stage.SummaryThis review provides ideas for the future application of immunology in the fight against such diseases, which is a hot topic currently. |
first_indexed | 2024-04-09T17:40:27Z |
format | Article |
id | doaj.art-34c7122f010645518590f78aa4326012 |
institution | Directory Open Access Journal |
issn | 1664-3224 |
language | English |
last_indexed | 2024-04-09T17:40:27Z |
publishDate | 2023-04-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Immunology |
spelling | doaj.art-34c7122f010645518590f78aa43260122023-04-17T05:35:26ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-04-011410.3389/fimmu.2023.11457881145788Immune-related mechanisms and immunotherapy in extragonadal germ cell tumorsWeigang Xiu0Jiyun Pang1Jiyun Pang2Yang Hu3Huashan Shi41Division of Thoracic Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, China1Division of Thoracic Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaPurpose of reviewExtragonadal germ cell tumors (EGCTs) are relatively rare tumors, accounting for 1%–5% of all GCTs. In this review, we summarize the current research progress regarding the pathogenesis, diagnosis, and treatment of EGCTs from an immunology perspective.Recent findingsThe histological origin of EGCTs is related to a gonadal origin, but they are located outside the gonad. They show great variation in morphology and can occur in the cranium, mediastinum, sacrococcygeal bone, and other areas. The pathogenesis of EGCTs is poorly understood, and their differential diagnosis is extensive and challenging. EGCT behavior varies greatly according to patient age, histological subtype, and clinical stage.SummaryThis review provides ideas for the future application of immunology in the fight against such diseases, which is a hot topic currently.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145788/fullextragonadal germ cell tumorimmunohistochemistryimmunotherapymechanismdiagnosis |
spellingShingle | Weigang Xiu Jiyun Pang Jiyun Pang Yang Hu Huashan Shi Immune-related mechanisms and immunotherapy in extragonadal germ cell tumors Frontiers in Immunology extragonadal germ cell tumor immunohistochemistry immunotherapy mechanism diagnosis |
title | Immune-related mechanisms and immunotherapy in extragonadal germ cell tumors |
title_full | Immune-related mechanisms and immunotherapy in extragonadal germ cell tumors |
title_fullStr | Immune-related mechanisms and immunotherapy in extragonadal germ cell tumors |
title_full_unstemmed | Immune-related mechanisms and immunotherapy in extragonadal germ cell tumors |
title_short | Immune-related mechanisms and immunotherapy in extragonadal germ cell tumors |
title_sort | immune related mechanisms and immunotherapy in extragonadal germ cell tumors |
topic | extragonadal germ cell tumor immunohistochemistry immunotherapy mechanism diagnosis |
url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145788/full |
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