Many lncRNAs, 5’UTRs, and pseudogenes are translated and some are likely to express functional proteins

Many lncRNAs, 5’UTRs, and pseudogenes are translated and some are likely to express functional proteins

Using a new bioinformatic method to analyze ribosome profiling data, we show that 40% of lncRNAs and pseudogene RNAs expressed in human cells are translated. In addition, ~35% of mRNA coding genes are translated upstream of the primary protein-coding region (uORFs) and 4% are translated downstream (...

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Bibliographic Details
Main Authors: Zhe Ji, Ruisheng Song, Aviv Regev, Kevin Struhl
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-12-01
Series:eLife
Subjects:
non-coding RNA
translation
ribosome profiling
5'UTR
pseudogene
biological function
Online Access:https://elifesciences.org/articles/08890

Internet

https://elifesciences.org/articles/08890

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