Temperature Sensing Properties of Biocompatible Yb/Er-Doped GdF<sub>3</sub> and YF<sub>3</sub> Mesocrystals
Y<sub>0.8−x</sub>Gd<sub>x</sub>F<sub>3</sub>:Yb/Er mesocrystals with a biocompatible surface and diverse morphological characteristics were successfully synthesized using chitosan-assisted solvothermal processing. Their structural properties, studied using X-ray p...
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MDPI AG
2023-12-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/15/1/6 |
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| author | Ivana Dinić Marina Vuković Maria Eugenia Rabanal Milica Milošević Marta Bukumira Nina Tomić Miloš Tomić Lidija Mančić Nenad Ignjatović |
| author_facet | Ivana Dinić Marina Vuković Maria Eugenia Rabanal Milica Milošević Marta Bukumira Nina Tomić Miloš Tomić Lidija Mančić Nenad Ignjatović |
| author_sort | Ivana Dinić |
| collection | DOAJ |
| description | Y<sub>0.8−x</sub>Gd<sub>x</sub>F<sub>3</sub>:Yb/Er mesocrystals with a biocompatible surface and diverse morphological characteristics were successfully synthesized using chitosan-assisted solvothermal processing. Their structural properties, studied using X-ray powder diffraction, Fourier transform infrared spectroscopy, scanning and transmission electron microscopy and energy dispersive X-ray analysis, were further correlated with the up-conversion emission (λ<sub>exc</sub> = 976 nm) recorded in function of temperature. Based on the change in the visible green emissions originating from the thermally coupled <sup>2</sup>H<sub>11/2</sub> and <sup>4</sup>S<sub>3/2</sub> levels of Er<sup>3+</sup>, the corresponding LIR was acquired in the physiologically relevant range of temperatures (25–50 °C). The detected absolute sensitivity of about 0.0042 °C<sup>−1</sup>, along with the low cytotoxicity toward both normal human lung fibroblasts (MRC-5) and cancerous lung epithelial (A549) cells, indicate a potential for use in temperature sensing in biomedicine. Additionally, their enhanced internalization in cells, without suppression of cell viability, enabled in vitro labeling of cancer and healthy cells upon 976 nm laser irradiation. |
| first_indexed | 2024-03-08T10:46:02Z |
| format | Article |
| id | doaj.art-34c9692ef87d474388bf53d9ff048fbe |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-08T10:46:02Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-34c9692ef87d474388bf53d9ff048fbe2024-01-26T17:10:53ZengMDPI AGJournal of Functional Biomaterials2079-49832023-12-01151610.3390/jfb15010006Temperature Sensing Properties of Biocompatible Yb/Er-Doped GdF<sub>3</sub> and YF<sub>3</sub> MesocrystalsIvana Dinić0Marina Vuković1Maria Eugenia Rabanal2Milica Milošević3Marta Bukumira4Nina Tomić5Miloš Tomić6Lidija Mančić7Nenad Ignjatović8Institute of Technical Science of SASA, 110000 Belgrade, SerbiaInnovative Centre, Faculty of Chemistry, University of Belgrade, 110000 Belgrade, SerbiaDepartment of Materials Science and Engineering and Chemical Engineering, Universidad Carlos III de Madrid and IAAB, 28903 Madrid, SpainDepartment of Radiation Chemistry and Physics, Vinča Institute of Nuclear Sciences—National Institute of the Republic of Serbia, University of Belgrade, Vinča, 110000 Belgrade, SerbiaInstitute of Physics Belgrade, National Institute of the Republic of Serbia, University of Belgrade, 110000 Belgrade, SerbiaInstitute of Technical Science of SASA, 110000 Belgrade, SerbiaInstitute of Technical Science of SASA, 110000 Belgrade, SerbiaInstitute of Technical Science of SASA, 110000 Belgrade, SerbiaInstitute of Technical Science of SASA, 110000 Belgrade, SerbiaY<sub>0.8−x</sub>Gd<sub>x</sub>F<sub>3</sub>:Yb/Er mesocrystals with a biocompatible surface and diverse morphological characteristics were successfully synthesized using chitosan-assisted solvothermal processing. Their structural properties, studied using X-ray powder diffraction, Fourier transform infrared spectroscopy, scanning and transmission electron microscopy and energy dispersive X-ray analysis, were further correlated with the up-conversion emission (λ<sub>exc</sub> = 976 nm) recorded in function of temperature. Based on the change in the visible green emissions originating from the thermally coupled <sup>2</sup>H<sub>11/2</sub> and <sup>4</sup>S<sub>3/2</sub> levels of Er<sup>3+</sup>, the corresponding LIR was acquired in the physiologically relevant range of temperatures (25–50 °C). The detected absolute sensitivity of about 0.0042 °C<sup>−1</sup>, along with the low cytotoxicity toward both normal human lung fibroblasts (MRC-5) and cancerous lung epithelial (A549) cells, indicate a potential for use in temperature sensing in biomedicine. Additionally, their enhanced internalization in cells, without suppression of cell viability, enabled in vitro labeling of cancer and healthy cells upon 976 nm laser irradiation.https://www.mdpi.com/2079-4983/15/1/6optical thermometryup-conversionYF<sub>3</sub>GdF<sub>3</sub>chitosanmesocrystals |
| spellingShingle | Ivana Dinić Marina Vuković Maria Eugenia Rabanal Milica Milošević Marta Bukumira Nina Tomić Miloš Tomić Lidija Mančić Nenad Ignjatović Temperature Sensing Properties of Biocompatible Yb/Er-Doped GdF<sub>3</sub> and YF<sub>3</sub> Mesocrystals Journal of Functional Biomaterials optical thermometry up-conversion YF<sub>3</sub> GdF<sub>3</sub> chitosan mesocrystals |
| title | Temperature Sensing Properties of Biocompatible Yb/Er-Doped GdF<sub>3</sub> and YF<sub>3</sub> Mesocrystals |
| title_full | Temperature Sensing Properties of Biocompatible Yb/Er-Doped GdF<sub>3</sub> and YF<sub>3</sub> Mesocrystals |
| title_fullStr | Temperature Sensing Properties of Biocompatible Yb/Er-Doped GdF<sub>3</sub> and YF<sub>3</sub> Mesocrystals |
| title_full_unstemmed | Temperature Sensing Properties of Biocompatible Yb/Er-Doped GdF<sub>3</sub> and YF<sub>3</sub> Mesocrystals |
| title_short | Temperature Sensing Properties of Biocompatible Yb/Er-Doped GdF<sub>3</sub> and YF<sub>3</sub> Mesocrystals |
| title_sort | temperature sensing properties of biocompatible yb er doped gdf sub 3 sub and yf sub 3 sub mesocrystals |
| topic | optical thermometry up-conversion YF<sub>3</sub> GdF<sub>3</sub> chitosan mesocrystals |
| url | https://www.mdpi.com/2079-4983/15/1/6 |
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