Tuning spacer length improves the functionality of the nanobody-based VEGFR2 CAR T cell

Tuning spacer length improves the functionality of the nanobody-based VEGFR2 CAR T cell

Abstract Background The chimeric antigen receptor-expressing T (CAR-T) cells for cancer immunotherapy have obtained considerable clinical importance. CAR T cells need an optimized intracellular signaling domain to get appropriately activated and also for the proper antigen recognition, the length an...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Fatemeh Hajari Taheri, Mahmoud Hassani, Zahra Sharifzadeh, Mahdi Behdani, Shahryar Abdoli, Mahtab Sayadi, Kowsar Bagherzadeh, Arash Arashkia, Mohsen Abolhassani
Định dạng:	Bài viết
Ngôn ngữ:	English
Được phát hành:	BMC 2024-01-01
Loạt:	BMC Biotechnology
Những chủ đề:	Chimeric antigen receptor (CAR) IgG1 CH2-CH3 Hinge Spacer domain VEGFR2
Truy cập trực tuyến:	https://doi.org/10.1186/s12896-023-00827-0

Những quyển sách tương tự

Engineered Jurkat Cells for Targeting Prostate-Specific Membrane Antigen on Prostate Cancer Cells by Nanobody-Based Chimeric Antigen Receptor
Bằng: Mahmoud Hassani, et al.
Được phát hành: (2020-03-01)

Engineered Jurkat Cells for Targeting Prostate-Specific Membrane Antigen on Prostate Cancer Cells by Nanobody-Based Chimeric Antigen Receptor
Bằng: Mahmoud Hassani, et al.
Được phát hành: (2020-03-01)

Cell-specific targeting by engineered M13 bacteriophage expressing VEGFR2 nanobody
Bằng: Farideh Ranjibar, et al.
Được phát hành: (2018-09-01)

VEGFA, VEGFR1, VEGFR2 serum and cerebrospinal fluid concentration in patients with acute leukemia
Bằng: E. I. Zakharko, et al.
Được phát hành: (2024-04-01)

An Investigation of Vascular Endothelial Growth Factor (VEGFR-1 and VEGFR-2) in Burn Wound Healing
Bằng: L Abdulazeem, et al.
Được phát hành: (2022-04-01)

Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities
Bằng: Maiy Y. Jaballah, et al.
Được phát hành: (2019-01-01)

Seasonal expressions of VEGF and its receptors VEGFR1 and VEGFR2 in the prostate of the wild ground squirrels (<em>Spermophilus dauricus</em>)
Bằng: Yuchen Yao, et al.
Được phát hành: (2021-03-01)

Theoretical spectroscopic study of acetyl (CH3CO), vinoxy (CH2CHO), and 1-methylvinoxy (CH3COCH2) radicals. Barrierless formation processes of acetone in the gas phase [version 2; peer review: 2 approved]
Bằng: Najia Komiha, et al.
Được phát hành: (2022-03-01)

Computational Modeling to Quantify the Contributions of VEGFR1, VEGFR2, and Lateral Inhibition in Sprouting Angiogenesis
Bằng: Clemens Kühn, et al.
Được phát hành: (2019-03-01)

A novel nanobody-based immunocytokine of a mutant interleukin-2 as a potential cancer therapeutic
Bằng: Arezoo Beig Parikhani, et al.
Được phát hành: (2024-02-01)

VEGF-A, sVEGFR-1, and sVEGFR-2 in BCR-ABL negative myeloproliferative neoplasms
Bằng: Grażyna Gadomska, et al.
Được phát hành: (2017-01-01)

Role of VEGF-VEGFR2 signaling pathway in psoriasis
Bằng: Xiaomei LUO, et al.
Được phát hành: (2022-10-01)

Rutacecarpine Inhibits Angiogenesis by Targeting the VEGFR2 and VEGFR2-Mediated Akt/mTOR/p70s6k Signaling Pathway
Bằng: Lijun Ji, et al.
Được phát hành: (2018-08-01)

Chicken-Derived Pattern Recognition Receptor chLGP2 Inhibits the Replication and Proliferation of Infectious Bronchitis Virus
Bằng: Kailu Wang, et al.
Được phát hành: (2022-01-01)

Optogenetic activation of striatal cholinergic interneurons regulates L-dopa-induced dyskinesias
Bằng: Tanuja Bordia, et al.
Được phát hành: (2016-07-01)

Radiosynthesis and in vivo imaging of [11C]BTFP, a potent inhibitor of VEGFR2
Bằng: Ramesh Neelamegam, et al.
Được phát hành: (2022-01-01)

The VEGFs/VEGFRs system in Alzheimer’s and Parkinson’s diseases: Pathophysiological roles and therapeutic implications
Bằng: Claudia Ceci, et al.
Được phát hành: (2024-03-01)

Generating a Novel Bispecific Nanobody to Enhance Antitumor Activity
Bằng: Qiuhan Ge, et al.
Được phát hành: (2020-06-01)

Ab Initio Study of the Large Amplitude Motions of Various Monosubstituted Isotopologues of Methylamine (CH3-NH2)
Bằng: Muneerah Mogren Al-Mogren, et al.
Được phát hành: (2021-09-01)

Carbon Dioxide and Methane at a Desert Site—A Case Study at Railroad Valley Playa, Nevada, USA
Bằng: Akihiko Kuze, et al.
Được phát hành: (2011-12-01)

Conjugation of VEGFR1/R2-targeting peptide with gold nanoparticles to enhance antiangiogenic and antitumoral activity
Bằng: Pegah Zanjanchi, et al.
Được phát hành: (2022-01-01)

VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis
Bằng: Gareth W. Fearnley, et al.
Được phát hành: (2016-05-01)

VEGFR2 regulates endothelial differentiation of colon cancer cells
Bằng: Zhiyong Liu, et al.
Được phát hành: (2017-08-01)

OVEREXPRESSION OF VEGF AND VEGFR2 IN CHRONIC HEPATITIS AND LIVER CIRRHOSIS
Bằng: Raluca Amalia Ceauşu, et al.
Được phát hành: (2016-12-01)

Inhibition of AGS Cancer Cell Proliferation following siRNA-Mediated Downregulation of VEGFR2
Bằng: Ali Zarei Mahmudabadi, et al.
Được phát hành: (2016-09-01)

Novel Anticancer Fused Pyrazole Derivatives as EGFR and VEGFR-2 Dual TK Inhibitors
Bằng: Nashwa M. Saleh, et al.
Được phát hành: (2020-01-01)

Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways
Bằng: Grace X. Li, et al.
Được phát hành: (2021-02-01)

Evaluation of the constitutive expression levels of ch-TLR 3, ch-TLR 4, ch-TLR 15 and ch-TLR 21 genes in the Peripheral Blood Mononuclear Cells of native Indian poultry breeds, Aseel and Kadaknath
Bằng: H. C. Chauhan, et al.
Được phát hành: (2013-06-01)

EL CH'ULEL EN LOS ALTOS DE CHIAPAS: ESTADO DE LA CUESTIÓN
Bằng: Elena Lunes Jiménez
Được phát hành: (2011-06-01)

VEGFR-3 signaling in macrophages: friend or foe in disease?
Bằng: Saranya Kannan, et al.
Được phát hành: (2024-02-01)

VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis
Bằng: Jeon Yeob Jang, et al.
Được phát hành: (2017-04-01)

2018–2019 Florida Citrus Production Guide: Decay Control of Florida Fresh Citrus
Bằng: Mark A. Ritenour, et al.
Được phát hành: (2019-03-01)

Water Measurement for Agricultural Irrigation and Drainage Systems
Bằng: Brian Boman, et al.
Được phát hành: (2006-10-01)

Design and Construction of Screened Wells for Agricultural Irrigation Systems
Bằng: Brian Boman, et al.
Được phát hành: (2006-10-01)

Control and Automation in Citrus Microirrigation Systems
Bằng: Brian Boman, et al.
Được phát hành: (2002-07-01)

Water Table Measurement and Monitoring for Flatwoods Citrus
Bằng: Brian Boman, et al.
Được phát hành: (2002-07-01)

Chlorine Use In Produce Packing Lines
Bằng: Mark A. Ritenour, et al.
Được phát hành: (2002-10-01)

Medicinal Use of Citrus
Bằng: James J. Ferguson
Được phát hành: (2002-10-01)

Drainage Systems for Flatwoods Citrus in Florida
Bằng: Brian Boman, et al.
Được phát hành: (2002-07-01)

Fertigation Nutrient Sources and Application Considerations for Citrus
Bằng: Brian Boman, et al.
Được phát hành: (2002-07-01)