Tuning spacer length improves the functionality of the nanobody-based VEGFR2 CAR T cell

Tuning spacer length improves the functionality of the nanobody-based VEGFR2 CAR T cell

Abstract Background The chimeric antigen receptor-expressing T (CAR-T) cells for cancer immunotherapy have obtained considerable clinical importance. CAR T cells need an optimized intracellular signaling domain to get appropriately activated and also for the proper antigen recognition, the length an...

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Bibliographic Details
Main Authors: Fatemeh Hajari Taheri, Mahmoud Hassani, Zahra Sharifzadeh, Mahdi Behdani, Shahryar Abdoli, Mahtab Sayadi, Kowsar Bagherzadeh, Arash Arashkia, Mohsen Abolhassani
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Biotechnology
Subjects:
Chimeric antigen receptor (CAR)
IgG1 CH2-CH3
Hinge
Spacer domain
VEGFR2
Online Access:https://doi.org/10.1186/s12896-023-00827-0

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