Tuning spacer length improves the functionality of the nanobody-based VEGFR2 CAR T cell

Tuning spacer length improves the functionality of the nanobody-based VEGFR2 CAR T cell

Abstract Background The chimeric antigen receptor-expressing T (CAR-T) cells for cancer immunotherapy have obtained considerable clinical importance. CAR T cells need an optimized intracellular signaling domain to get appropriately activated and also for the proper antigen recognition, the length an...

書目詳細資料
Main Authors:	Fatemeh Hajari Taheri, Mahmoud Hassani, Zahra Sharifzadeh, Mahdi Behdani, Shahryar Abdoli, Mahtab Sayadi, Kowsar Bagherzadeh, Arash Arashkia, Mohsen Abolhassani
格式:	Article
語言:	English
出版:	BMC 2024-01-01
叢編:	BMC Biotechnology
主題:	Chimeric antigen receptor (CAR) IgG1 CH2-CH3 Hinge Spacer domain VEGFR2
在線閱讀:	https://doi.org/10.1186/s12896-023-00827-0

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