Tuning spacer length improves the functionality of the nanobody-based VEGFR2 CAR T cell
Abstract Background The chimeric antigen receptor-expressing T (CAR-T) cells for cancer immunotherapy have obtained considerable clinical importance. CAR T cells need an optimized intracellular signaling domain to get appropriately activated and also for the proper antigen recognition, the length an...
| Main Authors: | , , , , , , , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
BMC
2024-01-01
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| 叢編: | BMC Biotechnology |
| 主題: | |
| 在線閱讀: | https://doi.org/10.1186/s12896-023-00827-0 |