Whole-body magnetic resonance imaging (WB-MRI) reporting with the METastasis Reporting and Data System for Prostate Cancer (MET-RADS-P): inter-observer agreement between readers of different expertise levels
Abstract Background The METastasis Reporting and Data System for Prostate Cancer (MET-RADS-P) guidelines are designed to enable reproducible assessment in detecting and quantifying metastatic disease response using whole-body magnetic resonance imaging (WB-MRI) in patients with advanced prostate can...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | Cancer Imaging |
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| Online Access: | http://link.springer.com/article/10.1186/s40644-020-00350-x |
| _version_ | 1828898069538668544 |
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| author | Paola Pricolo Eleonora Ancona Paul Summers Jorge Abreu-Gomez Sarah Alessi Barbara Alicja Jereczek-Fossa Ottavio De Cobelli Franco Nolè Giuseppe Renne Massimo Bellomi Anwar Roshanali Padhani Giuseppe Petralia |
| author_facet | Paola Pricolo Eleonora Ancona Paul Summers Jorge Abreu-Gomez Sarah Alessi Barbara Alicja Jereczek-Fossa Ottavio De Cobelli Franco Nolè Giuseppe Renne Massimo Bellomi Anwar Roshanali Padhani Giuseppe Petralia |
| author_sort | Paola Pricolo |
| collection | DOAJ |
| description | Abstract Background The METastasis Reporting and Data System for Prostate Cancer (MET-RADS-P) guidelines are designed to enable reproducible assessment in detecting and quantifying metastatic disease response using whole-body magnetic resonance imaging (WB-MRI) in patients with advanced prostate cancer (APC). The purpose of our study was to evaluate the inter-observer agreement of WB-MRI examination reports produced by readers of different expertise when using the MET-RADS-P guidelines. Methods Fifty consecutive paired WB-MRI examinations, performed from December 2016 to February 2018 on 31 patients, were retrospectively examined to compare reports by a Senior Radiologist (9 years of experience in WB-MRI) and Resident Radiologist (after a 6-months training) using MET-RADS-P guidelines, for detection and for primary/dominant and secondary response assessment categories (RAC) scores assigned to metastatic disease in 14 body regions. Inter-observer agreement regarding RAC score was evaluated for each region by using weighted-Cohen’s Kappa statistics (K). Results The number of metastatic regions reported by the Senior Radiologist (249) and Resident Radiologist (251) was comparable. For the primary/dominant RAC pattern, the agreement between readers was excellent for the metastatic findings in cervical, dorsal, and lumbosacral spine, pelvis, limbs, lungs and other sites (K:0.81–1.0), substantial for thorax, retroperitoneal nodes, other nodes and liver (K:0.61–0.80), moderate for pelvic nodes (K:0.56), fair for primary soft tissue and not assessable for skull due to the absence of findings. For the secondary RAC pattern, agreement between readers was excellent for the metastatic findings in cervical spine (K:0.93) and retroperitoneal nodes (K:0.89), substantial for those in dorsal spine, pelvis, thorax, limbs and pelvic nodes (K:0.61–0.80), and moderate for lumbosacral spine (K:0.44). Conclusions We found inter-observer agreement between two readers of different expertise levels to be excellent in bone, but mixed in other body regions. Considering the importance of bone metastases in patients with APC, our results favor the use of MET-RADS-P in response to the growing clinical need for monitoring of metastasis in these patients. |
| first_indexed | 2024-12-13T15:09:08Z |
| format | Article |
| id | doaj.art-34ca75da3c93417fb2c7aa86a5e84493 |
| institution | Directory Open Access Journal |
| issn | 1470-7330 |
| language | English |
| last_indexed | 2024-12-13T15:09:08Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj.art-34ca75da3c93417fb2c7aa86a5e844932022-12-21T23:40:56ZengBMCCancer Imaging1470-73302020-10-0120111310.1186/s40644-020-00350-xWhole-body magnetic resonance imaging (WB-MRI) reporting with the METastasis Reporting and Data System for Prostate Cancer (MET-RADS-P): inter-observer agreement between readers of different expertise levelsPaola Pricolo0Eleonora Ancona1Paul Summers2Jorge Abreu-Gomez3Sarah Alessi4Barbara Alicja Jereczek-Fossa5Ottavio De Cobelli6Franco Nolè7Giuseppe Renne8Massimo Bellomi9Anwar Roshanali Padhani10Giuseppe Petralia11Division of Radiology, IEO European Institute of Oncology IRCCSDivision of Radiology, IEO European Institute of Oncology IRCCSDivision of Radiology, IEO European Institute of Oncology IRCCSDepartment of Medical Imaging, Sunnybrook Health Science CentreDivision of Radiology, IEO European Institute of Oncology IRCCSDivision of Radiotherapy, IEO European Institute of Oncology IRCCSDepartment of Oncology and Hemato-Oncology, University of MilanDivision of Urogenital and Head and Neck Tumours Medical Treatment, IEO European Institute of Oncology IRCCSDivision of Uropathology and Intraoperative Diagnostics, IEO European Institute of Oncology IRCCSDivision of Radiology, IEO European Institute of Oncology IRCCSPaul Strickland Scanner Centre, Mount Vernon Cancer CentreDepartment of Oncology and Hemato-Oncology, University of MilanAbstract Background The METastasis Reporting and Data System for Prostate Cancer (MET-RADS-P) guidelines are designed to enable reproducible assessment in detecting and quantifying metastatic disease response using whole-body magnetic resonance imaging (WB-MRI) in patients with advanced prostate cancer (APC). The purpose of our study was to evaluate the inter-observer agreement of WB-MRI examination reports produced by readers of different expertise when using the MET-RADS-P guidelines. Methods Fifty consecutive paired WB-MRI examinations, performed from December 2016 to February 2018 on 31 patients, were retrospectively examined to compare reports by a Senior Radiologist (9 years of experience in WB-MRI) and Resident Radiologist (after a 6-months training) using MET-RADS-P guidelines, for detection and for primary/dominant and secondary response assessment categories (RAC) scores assigned to metastatic disease in 14 body regions. Inter-observer agreement regarding RAC score was evaluated for each region by using weighted-Cohen’s Kappa statistics (K). Results The number of metastatic regions reported by the Senior Radiologist (249) and Resident Radiologist (251) was comparable. For the primary/dominant RAC pattern, the agreement between readers was excellent for the metastatic findings in cervical, dorsal, and lumbosacral spine, pelvis, limbs, lungs and other sites (K:0.81–1.0), substantial for thorax, retroperitoneal nodes, other nodes and liver (K:0.61–0.80), moderate for pelvic nodes (K:0.56), fair for primary soft tissue and not assessable for skull due to the absence of findings. For the secondary RAC pattern, agreement between readers was excellent for the metastatic findings in cervical spine (K:0.93) and retroperitoneal nodes (K:0.89), substantial for those in dorsal spine, pelvis, thorax, limbs and pelvic nodes (K:0.61–0.80), and moderate for lumbosacral spine (K:0.44). Conclusions We found inter-observer agreement between two readers of different expertise levels to be excellent in bone, but mixed in other body regions. Considering the importance of bone metastases in patients with APC, our results favor the use of MET-RADS-P in response to the growing clinical need for monitoring of metastasis in these patients.http://link.springer.com/article/10.1186/s40644-020-00350-xWhole body MRIProstate cancerInter-observer agreementMET-RADS-P |
| spellingShingle | Paola Pricolo Eleonora Ancona Paul Summers Jorge Abreu-Gomez Sarah Alessi Barbara Alicja Jereczek-Fossa Ottavio De Cobelli Franco Nolè Giuseppe Renne Massimo Bellomi Anwar Roshanali Padhani Giuseppe Petralia Whole-body magnetic resonance imaging (WB-MRI) reporting with the METastasis Reporting and Data System for Prostate Cancer (MET-RADS-P): inter-observer agreement between readers of different expertise levels Cancer Imaging Whole body MRI Prostate cancer Inter-observer agreement MET-RADS-P |
| title | Whole-body magnetic resonance imaging (WB-MRI) reporting with the METastasis Reporting and Data System for Prostate Cancer (MET-RADS-P): inter-observer agreement between readers of different expertise levels |
| title_full | Whole-body magnetic resonance imaging (WB-MRI) reporting with the METastasis Reporting and Data System for Prostate Cancer (MET-RADS-P): inter-observer agreement between readers of different expertise levels |
| title_fullStr | Whole-body magnetic resonance imaging (WB-MRI) reporting with the METastasis Reporting and Data System for Prostate Cancer (MET-RADS-P): inter-observer agreement between readers of different expertise levels |
| title_full_unstemmed | Whole-body magnetic resonance imaging (WB-MRI) reporting with the METastasis Reporting and Data System for Prostate Cancer (MET-RADS-P): inter-observer agreement between readers of different expertise levels |
| title_short | Whole-body magnetic resonance imaging (WB-MRI) reporting with the METastasis Reporting and Data System for Prostate Cancer (MET-RADS-P): inter-observer agreement between readers of different expertise levels |
| title_sort | whole body magnetic resonance imaging wb mri reporting with the metastasis reporting and data system for prostate cancer met rads p inter observer agreement between readers of different expertise levels |
| topic | Whole body MRI Prostate cancer Inter-observer agreement MET-RADS-P |
| url | http://link.springer.com/article/10.1186/s40644-020-00350-x |
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