Histone Chaperone Jun Dimerization Protein 2 (JDP2): Role in Cellular Senescence and Aging

Histone Chaperone Jun Dimerization Protein 2 (JDP2): Role in Cellular Senescence and Aging

Transcription factor Jun dimerization protein 2 (JDP2) binds directly to histones and DNA, and inhibits p300-mediated acetylation of core histones and reconstituted nucleosomes that contain JDP2-recognition DNA sequences. The region of JDP2 that encompasses its histone-binding domain and DNA-binding...

Full description

Bibliographic Details
Main Authors:	Yu-Chang Huang, Shigeo Saito, Kazunari Kzaushige Yokoyama
Format:	Article
Language:	English
Published:	Wiley 2010-10-01
Series:	Kaohsiung Journal of Medical Sciences
Subjects:	Arf Jun dimerization protein 2 p16Ink4a polycomb repressive complex replicative senescence
Online Access:	http://www.sciencedirect.com/science/article/pii/S1607551X10700814

Similar Items

Epigenetic regulation of p16Ink4a and Arf by JDP2 in cellular senescence
by: Nakade Koji, et al.
Published: (2010-05-01)

Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery
by: Kenly Wuputra, et al.
Published: (2023-08-01)

Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease
by: Liat Oss-Ronen, et al.
Published: (2022-08-01)

Control of Oxidative Stress and Generation of Induced Pluripotent Stem Cell-like Cells by Jun Dimerization Protein 2
by: Naoto Yamaguchi, et al.
Published: (2013-07-01)

Towards understanding of PRC2 binding to RNA
by: Yan, Junli, et al.
Published: (2021)

Enhancer of Zeste Homolog 2 (EZH2) Contributes to Rod Photoreceptor Death Process in Several Forms of Retinal Degeneration and Its Activity Can Serve as a Biomarker for Therapy Efficacy
by: Martial Mbefo, et al.
Published: (2021-08-01)

Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish
by: Ludivine Raby, et al.
Published: (2021-11-01)

Prognostic implications of polycomb proteins ezh2, suz12, and eed1 and histone modification by H3K27me3 in sarcoma
by: Yong Jin Cho, et al.
Published: (2018-02-01)

Transcriptomics-Based Repositioning of Natural Compound, Eudesmin, as a PRC2 Modulator
by: Sang Ah Yi, et al.
Published: (2021-09-01)

Mechanisms guiding Polycomb activities during gene silencing in Arabidopsis thaliana
by: Chongsheng eHe, et al.
Published: (2013-11-01)

Tissue-Specific Tumour Suppressor and Oncogenic Activities of the Polycomb-like Protein MTF2
by: Mzwanele Ngubo, et al.
Published: (2023-09-01)

Low-level repressive histone marks fine-tune gene transcription in neural stem cells
by: Arjun Rajan, et al.
Published: (2023-06-01)

Boundaries potentiate polycomb response element-mediated silencing
by: Maksim Erokhin, et al.
Published: (2021-06-01)

Identification of polycomb repressive complex 1 and 2 core components in hexaploid bread wheat
by: Beáta Strejčková, et al.
Published: (2020-10-01)

No Easy Way Out for EZH2: Its Pleiotropic, Noncanonical Effects on Gene Regulation and Cellular Function
by: Jun Wang, et al.
Published: (2020-12-01)

Exploring the Association Between PRC2 Genes Variants and Lung Cancer Risk in Chinese Han Population
by: Gao M, et al.
Published: (2023-07-01)

Dynamics of H3K27me3 Modification on Plant Adaptation to Environmental Cues
by: Qingwen Shen, et al.
Published: (2021-06-01)

Histones and their modifications in ovarian cancer – drivers of disease and therapeutic targets
by: Deborah Joy Marsh, et al.
Published: (2014-06-01)

Polycomb-like Proteins in Gene Regulation and Cancer
by: Sabrina Fischer, et al.
Published: (2023-04-01)

Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast
by: Yoyo Chih-Yun Yu, et al.
Published: (2020-03-01)

Evolution and function of epigenetic processes in the endosperm
by: Claudia eKöhler, et al.
Published: (2015-03-01)

p15INK4B is an alternative marker of senescent tumor cells in colorectal cancer
by: Soon Sang Park, et al.
Published: (2023-02-01)

Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
by: Sean J. Farley, et al.
Published: (2022-12-01)

Targeting of the C-Jun/BCL-XL/P21 Axis Accelerates the Switch from Senescence to Apoptosis Upon ROC1 Knockdown in Gastric Cancer Cells
by: Ping Chen, et al.
Published: (2018-07-01)

Drosophila DNA-Binding Proteins in Polycomb Repression
by: Maksim Erokhin, et al.
Published: (2018-01-01)

Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3
by: Ksenia Finogenova, et al.
Published: (2020-11-01)

Jun Dimerization Protein 2 (JDP2) Increases p53 Transactivation by Decreasing MDM2
by: Kasey Price, et al.
Published: (2024-02-01)

Truncated Isoforms of lncRNA ANRIL Are Overexpressed in Bladder Cancer, But Do Not Contribute to Repression of INK4 Tumor Suppressors
by: Michèle J. Hoffmann, et al.
Published: (2015-12-01)

Conversion of random X-inactivation to imprinted X-inactivation by maternal PRC2
by: Clair Harris, et al.
Published: (2019-04-01)

Chromatin state profiling reveals PRC2 inhibition as a therapeutic target in NRAS–mutant melanoma
by: Christopher J. Terranova
Published: (2021-09-01)

Dysregulated Polycomb Repressive Complex 2 contributes to chronic obstructive pulmonary disease by rewiring stem cell fate
by: Aria L. Byrd, et al.
Published: (2023-01-01)

Synergistic Anti-Ageing through Senescent Cells Specific Reprogramming
by: Rui Chen, et al.
Published: (2022-02-01)

Selective Concurrence of the Long Non-Coding RNA MALAT1 and the Polycomb Repressive Complex 2 to Promoter Regions of Active Genes in MCF7 Breast Cancer Cells
by: Felipe Arratia, et al.
Published: (2023-05-01)

Correlations between biomarkers of senescent cell accumulation at the systemic, tissue and cellular levels in elderly patients
by: Anna Grigorevna Sorokina, et al.
Published: (2023-06-01)

Molecular Regulation of the Polycomb Repressive-Deubiquitinase
by: Cameron J. Reddington, et al.
Published: (2020-10-01)

Chromatin and gene expression changes during female Drosophila germline stem cell development illuminate the biology of highly potent stem cells
by: Liang-Yu Pang, et al.
Published: (2023-10-01)

BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate
by: Ruiqi Liu, et al.
Published: (2023-04-01)

Systematic discovery of novel eukaryotic transcriptional regulators using sequence homology independent prediction
by: Flavia Bossi, et al.
Published: (2017-06-01)

Bone Marrow Senescence and the Microenvironment of Hematological Malignancies
by: Charlotte Hellmich, et al.
Published: (2020-02-01)

The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) – Mechanisms and Opportunities.
by: Kathrin Maria Bernt, et al.
Published: (2016-05-01)