Chemical Characterization and Antioxidant, Antimicrobial, and Anti-Inflammatory Activities of South Brazilian Organic Propolis.
South Brazilian organic propolis (OP), which has never been studied before, was assessed and its chemical composition, scavenging potential of reactive oxygen species, antimicrobial and anti-inflammatory activities are herein presented. Based on the chemical profile obtained using HPLC, OP was group...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5089781?pdf=render |
| _version_ | 1811212105263611904 |
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| author | Ana Paula Tiveron Pedro Luiz Rosalen Marcelo Franchin Risia Cristina Coelho Lacerda Bruno Bueno-Silva Bruna Benso Carina Denny Masaharu Ikegaki Severino Matias de Alencar |
| author_facet | Ana Paula Tiveron Pedro Luiz Rosalen Marcelo Franchin Risia Cristina Coelho Lacerda Bruno Bueno-Silva Bruna Benso Carina Denny Masaharu Ikegaki Severino Matias de Alencar |
| author_sort | Ana Paula Tiveron |
| collection | DOAJ |
| description | South Brazilian organic propolis (OP), which has never been studied before, was assessed and its chemical composition, scavenging potential of reactive oxygen species, antimicrobial and anti-inflammatory activities are herein presented. Based on the chemical profile obtained using HPLC, OP was grouped into seven variants (OP1-OP7) and all of them exhibited high scavenging activity, mainly against superoxide and hypochlorous acid species. OP1, OP2, and OP3 had the smallest minimal inhibitory concentration (MIC) against Gram-positive bacteria Streptococcus mutans, Streptococcus oralis, and Streptococcus aureus (12.5-100 μg/mL). OP1, OP2, OP3, and OP4 were more effective against Pseudomonas aeruginosa (Gram-negative), with MIC values ranging from 100 to 200 μg/mL. OP6 showed anti-inflammatory activity by decreasing NF-kB activation and TNF-α release in RAW 264.7 macrophages, and expressing the NF-κB-luciferase reporter stable gene. Therefore, south Brazilian OP can be considered an excellent source of bioactive compounds with great potential of application in the pharmaceutical and food industry. |
| first_indexed | 2024-04-12T05:24:26Z |
| format | Article |
| id | doaj.art-34ce19aa2c984deb85dd2df89eb84c56 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T05:24:26Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-34ce19aa2c984deb85dd2df89eb84c562022-12-22T03:46:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011111e016558810.1371/journal.pone.0165588Chemical Characterization and Antioxidant, Antimicrobial, and Anti-Inflammatory Activities of South Brazilian Organic Propolis.Ana Paula TiveronPedro Luiz RosalenMarcelo FranchinRisia Cristina Coelho LacerdaBruno Bueno-SilvaBruna BensoCarina DennyMasaharu IkegakiSeverino Matias de AlencarSouth Brazilian organic propolis (OP), which has never been studied before, was assessed and its chemical composition, scavenging potential of reactive oxygen species, antimicrobial and anti-inflammatory activities are herein presented. Based on the chemical profile obtained using HPLC, OP was grouped into seven variants (OP1-OP7) and all of them exhibited high scavenging activity, mainly against superoxide and hypochlorous acid species. OP1, OP2, and OP3 had the smallest minimal inhibitory concentration (MIC) against Gram-positive bacteria Streptococcus mutans, Streptococcus oralis, and Streptococcus aureus (12.5-100 μg/mL). OP1, OP2, OP3, and OP4 were more effective against Pseudomonas aeruginosa (Gram-negative), with MIC values ranging from 100 to 200 μg/mL. OP6 showed anti-inflammatory activity by decreasing NF-kB activation and TNF-α release in RAW 264.7 macrophages, and expressing the NF-κB-luciferase reporter stable gene. Therefore, south Brazilian OP can be considered an excellent source of bioactive compounds with great potential of application in the pharmaceutical and food industry.http://europepmc.org/articles/PMC5089781?pdf=render |
| spellingShingle | Ana Paula Tiveron Pedro Luiz Rosalen Marcelo Franchin Risia Cristina Coelho Lacerda Bruno Bueno-Silva Bruna Benso Carina Denny Masaharu Ikegaki Severino Matias de Alencar Chemical Characterization and Antioxidant, Antimicrobial, and Anti-Inflammatory Activities of South Brazilian Organic Propolis. PLoS ONE |
| title | Chemical Characterization and Antioxidant, Antimicrobial, and Anti-Inflammatory Activities of South Brazilian Organic Propolis. |
| title_full | Chemical Characterization and Antioxidant, Antimicrobial, and Anti-Inflammatory Activities of South Brazilian Organic Propolis. |
| title_fullStr | Chemical Characterization and Antioxidant, Antimicrobial, and Anti-Inflammatory Activities of South Brazilian Organic Propolis. |
| title_full_unstemmed | Chemical Characterization and Antioxidant, Antimicrobial, and Anti-Inflammatory Activities of South Brazilian Organic Propolis. |
| title_short | Chemical Characterization and Antioxidant, Antimicrobial, and Anti-Inflammatory Activities of South Brazilian Organic Propolis. |
| title_sort | chemical characterization and antioxidant antimicrobial and anti inflammatory activities of south brazilian organic propolis |
| url | http://europepmc.org/articles/PMC5089781?pdf=render |
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