Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutritional statuss⃞
The ELOVL3 protein is a very long-chain fatty acid elongase found in liver, skin, and brown adipose tissues. Circadian expression of the Elovl3 gene in the liver is perturbed in mutant CLOCK mice but persists in mice with severe hepatic dysfunction. A reliance on an intact clock, combined with the r...
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| Format: | Article |
| Language: | English |
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Elsevier
2006-12-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520432614 |
| _version_ | 1818640046613331968 |
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| author | Ana Anzulovich Alain Mir Michelle Brewer Gabriela Ferreyra Charles Vinson Ruben Baler |
| author_facet | Ana Anzulovich Alain Mir Michelle Brewer Gabriela Ferreyra Charles Vinson Ruben Baler |
| author_sort | Ana Anzulovich |
| collection | DOAJ |
| description | The ELOVL3 protein is a very long-chain fatty acid elongase found in liver, skin, and brown adipose tissues. Circadian expression of the Elovl3 gene in the liver is perturbed in mutant CLOCK mice but persists in mice with severe hepatic dysfunction. A reliance on an intact clock, combined with the refractoriness to liver decompensation and the finding of a robust sexually dimorphic pattern of expression, evince a particularly complex mode of transcriptional control. The Elovl3 gene upstream region was repressed by RevErbα and activated by sterol-regulatory element binding protein-1 (SREBP1) transcription factors. We propose that the temporal coordination of RevErbα and SREBP1 activities integrates clock and nutrition signals to drive a subset of oscillatory transcripts in the liver. Proteolytic activation of SREBP1 is circadian in the liver, and because the cycle of SREBP1 activation was reversed after restricting meals to the inactive phase of the day, this factor could serve as an acute sensor of nutritional state. SREBP1 regulates many known lipogenic and cholesterogenic circadian genes; hence, our results could explain how feeding can override brain-derived entraining signals in the liver. This mechanism would permit a rapid adjustment in the sequence of key aspects of the absorptive and postabsorptive phases in the liver. |
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| format | Article |
| id | doaj.art-34cf8d8a8e814475899e652891605d60 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-16T23:05:03Z |
| publishDate | 2006-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-34cf8d8a8e814475899e652891605d602022-12-21T22:12:35ZengElsevierJournal of Lipid Research0022-22752006-12-01471226902700Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutritional statuss⃞Ana Anzulovich0Alain Mir1Michelle Brewer2Gabriela Ferreyra3Charles Vinson4Ruben Baler5Unit on Temporal Gene Expression, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892Unit on Temporal Gene Expression, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892Unit on Temporal Gene Expression, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892Science Policy Branch, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892The ELOVL3 protein is a very long-chain fatty acid elongase found in liver, skin, and brown adipose tissues. Circadian expression of the Elovl3 gene in the liver is perturbed in mutant CLOCK mice but persists in mice with severe hepatic dysfunction. A reliance on an intact clock, combined with the refractoriness to liver decompensation and the finding of a robust sexually dimorphic pattern of expression, evince a particularly complex mode of transcriptional control. The Elovl3 gene upstream region was repressed by RevErbα and activated by sterol-regulatory element binding protein-1 (SREBP1) transcription factors. We propose that the temporal coordination of RevErbα and SREBP1 activities integrates clock and nutrition signals to drive a subset of oscillatory transcripts in the liver. Proteolytic activation of SREBP1 is circadian in the liver, and because the cycle of SREBP1 activation was reversed after restricting meals to the inactive phase of the day, this factor could serve as an acute sensor of nutritional state. SREBP1 regulates many known lipogenic and cholesterogenic circadian genes; hence, our results could explain how feeding can override brain-derived entraining signals in the liver. This mechanism would permit a rapid adjustment in the sequence of key aspects of the absorptive and postabsorptive phases in the liver.http://www.sciencedirect.com/science/article/pii/S0022227520432614fatty acidelongasesterol-regulatory element binding protein target genesrestricted feedingdaily rhythmphase shift |
| spellingShingle | Ana Anzulovich Alain Mir Michelle Brewer Gabriela Ferreyra Charles Vinson Ruben Baler Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutritional statuss⃞ Journal of Lipid Research fatty acid elongase sterol-regulatory element binding protein target genes restricted feeding daily rhythm phase shift |
| title | Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutritional statuss⃞ |
| title_full | Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutritional statuss⃞ |
| title_fullStr | Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutritional statuss⃞ |
| title_full_unstemmed | Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutritional statuss⃞ |
| title_short | Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutritional statuss⃞ |
| title_sort | elovl3 a model gene to dissect homeostatic links between the circadian clock and nutritional statuss⃞ |
| topic | fatty acid elongase sterol-regulatory element binding protein target genes restricted feeding daily rhythm phase shift |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520432614 |
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