Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination
Background:. Children with sickle cell disease (SCD) are particularly prone to pneumococcal infection and administration of Prevenar 13 pneumococcal vaccine in Nigerian children with SCD is yet to be wide spread. This call for the need to study humoral immune responses stimulated by Prevenar 13 pneu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health
2022-07-01
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| Series: | Blood Science |
| Online Access: | http://journals.lww.com/10.1097/BS9.0000000000000115 |
| _version_ | 1828086680512364544 |
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| author | Ganiyu Olatunbosun Arinola Elizabeth Disu Adedokun Babatunde Christopher Olopade Olufunmilayo Olopade |
| author_facet | Ganiyu Olatunbosun Arinola Elizabeth Disu Adedokun Babatunde Christopher Olopade Olufunmilayo Olopade |
| author_sort | Ganiyu Olatunbosun Arinola |
| collection | DOAJ |
| description | Background:. Children with sickle cell disease (SCD) are particularly prone to pneumococcal infection and administration of Prevenar 13 pneumococcal vaccine in Nigerian children with SCD is yet to be wide spread. This call for the need to study humoral immune responses stimulated by Prevenar 13 pneumococcal vaccine in SCD children to confirm the benefit or otherwise for the use of Prevenar 13 pneumococcal vaccine.
Method:. The levels of humoral (innate and adaptive) immune factors and associated nutritionally essential trace elements were determined following Prevenar 13 pneumococcal vaccination of 23 Nigerian children with SCD. Serum innate humoral immune factors [Complement factors (C1q and C4), transferrin, ferritin, and C-reactive protein (CRP)] and adaptive humoral immune factors [IgG, IgA, IgM, and IgE] were determined using ELISA. Nutritionally essential trace elements such as iron (Fe), copper (Cu), and zinc (Zn) were measured also using an atomic absorption spectrophotometer.
Results:. The serum levels of certain innate humoral immune factors (ferritin, CRP, and C4), only one adaptive humoral immune factors (IgE), and essential trace elements (Fe, Zn, and Cu) were significantly elevated in children with SCD post Prevenar 13 pneumococcal vaccination when compared to prevaccination levels.
Conclusion:. Vaccination of children with SCD with Prevenar 13 pneumococcal vaccine was associated with increased levels of more innate humoral immune factors than adaptive factors. This study thus supports the administration of Prevenar 13 pneumococcal vaccination to children with SCD. |
| first_indexed | 2024-04-11T04:58:32Z |
| format | Article |
| id | doaj.art-34d253f7df8b41eb859489b416a510a5 |
| institution | Directory Open Access Journal |
| issn | 2543-6368 |
| language | English |
| last_indexed | 2024-04-11T04:58:32Z |
| publishDate | 2022-07-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Blood Science |
| spelling | doaj.art-34d253f7df8b41eb859489b416a510a52022-12-26T06:00:24ZengWolters Kluwer HealthBlood Science2543-63682022-07-014317017310.1097/BS9.0000000000000115202207000-00012Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccinationGaniyu Olatunbosun Arinola0Elizabeth Disu1Adedokun Babatunde2Christopher Olopade3Olufunmilayo Olopade4a Department of Immunology, College of Medicine, University of Ibadan, Nigeriab Department of Pediatrics, Lagos State University Teaching Hospital, Lagos State, Nigeriac Department of Medicine and the Center for Global Health, University of Chicago, Chicago, USAc Department of Medicine and the Center for Global Health, University of Chicago, Chicago, USAd Center for Clinical Cancer Genetics and the Center for Global Health, University of Chicago, Chicago, USA.Background:. Children with sickle cell disease (SCD) are particularly prone to pneumococcal infection and administration of Prevenar 13 pneumococcal vaccine in Nigerian children with SCD is yet to be wide spread. This call for the need to study humoral immune responses stimulated by Prevenar 13 pneumococcal vaccine in SCD children to confirm the benefit or otherwise for the use of Prevenar 13 pneumococcal vaccine. Method:. The levels of humoral (innate and adaptive) immune factors and associated nutritionally essential trace elements were determined following Prevenar 13 pneumococcal vaccination of 23 Nigerian children with SCD. Serum innate humoral immune factors [Complement factors (C1q and C4), transferrin, ferritin, and C-reactive protein (CRP)] and adaptive humoral immune factors [IgG, IgA, IgM, and IgE] were determined using ELISA. Nutritionally essential trace elements such as iron (Fe), copper (Cu), and zinc (Zn) were measured also using an atomic absorption spectrophotometer. Results:. The serum levels of certain innate humoral immune factors (ferritin, CRP, and C4), only one adaptive humoral immune factors (IgE), and essential trace elements (Fe, Zn, and Cu) were significantly elevated in children with SCD post Prevenar 13 pneumococcal vaccination when compared to prevaccination levels. Conclusion:. Vaccination of children with SCD with Prevenar 13 pneumococcal vaccine was associated with increased levels of more innate humoral immune factors than adaptive factors. This study thus supports the administration of Prevenar 13 pneumococcal vaccination to children with SCD.http://journals.lww.com/10.1097/BS9.0000000000000115 |
| spellingShingle | Ganiyu Olatunbosun Arinola Elizabeth Disu Adedokun Babatunde Christopher Olopade Olufunmilayo Olopade Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination Blood Science |
| title | Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination |
| title_full | Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination |
| title_fullStr | Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination |
| title_full_unstemmed | Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination |
| title_short | Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination |
| title_sort | assessment of humoral immunity and nutritionally essential trace elements in steady state sickle cell disease nigerian children before and after prevenar 13 pneumococcal vaccination |
| url | http://journals.lww.com/10.1097/BS9.0000000000000115 |
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