New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca<sup>2+</sup>-Modulating Activity Isolated from Sea Urchin Eggs
Herein, we report on the synthesis of a small set of linear precursors of an inosine analogue of cyclic ADP-ribose (cADPR), a second messenger involved in Ca<sup>2+</sup> mobilization from ryanodine receptor stores firstly isolated from sea urchin eggs extracts. The synthesized compounds...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-08-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/17/8/476 |
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| author | Stefano D’Errico Emy Basso Andrea Patrizia Falanga Maria Marzano Tullio Pozzan Vincenzo Piccialli Gennaro Piccialli Giorgia Oliviero Nicola Borbone |
| author_facet | Stefano D’Errico Emy Basso Andrea Patrizia Falanga Maria Marzano Tullio Pozzan Vincenzo Piccialli Gennaro Piccialli Giorgia Oliviero Nicola Borbone |
| author_sort | Stefano D’Errico |
| collection | DOAJ |
| description | Herein, we report on the synthesis of a small set of linear precursors of an inosine analogue of cyclic ADP-ribose (cADPR), a second messenger involved in Ca<sup>2+</sup> mobilization from ryanodine receptor stores firstly isolated from sea urchin eggs extracts. The synthesized compounds were obtained starting from inosine and are characterized by an N1-alkyl chain replacing the “northern” ribose and a phosphate group attached at the end of the N1-alkyl chain and/or 5′-sugar positions. Preliminary Ca<sup>2+</sup> mobilization assays, performed on differentiated C2C12 cells, are reported as well. |
| first_indexed | 2024-04-13T08:10:05Z |
| format | Article |
| id | doaj.art-34d2ce62e3cf4085aa475a1f333130b3 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-13T08:10:05Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-34d2ce62e3cf4085aa475a1f333130b32022-12-22T02:55:02ZengMDPI AGMarine Drugs1660-33972019-08-0117847610.3390/md17080476md17080476New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca<sup>2+</sup>-Modulating Activity Isolated from Sea Urchin EggsStefano D’Errico0Emy Basso1Andrea Patrizia Falanga2Maria Marzano3Tullio Pozzan4Vincenzo Piccialli5Gennaro Piccialli6Giorgia Oliviero7Nicola Borbone8Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, via Domenico Montesano 49, Napoli 80131, ItalyConsiglio Nazionale delle Ricerche, Dipartimento di Scienze Biomediche, Istituto di Neuroscienze (Sezione di Padova), viale Giuseppe Colombo 3, Padova 35131, ItalyDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, via Sergio Pansini 5, Napoli 80131, ItalyDipartimento di Farmacia, Università degli Studi di Napoli Federico II, via Domenico Montesano 49, Napoli 80131, ItalyConsiglio Nazionale delle Ricerche, Dipartimento di Scienze Biomediche, Istituto di Neuroscienze (Sezione di Padova), viale Giuseppe Colombo 3, Padova 35131, ItalyDipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, via Cintia, 26, Napoli 80126, ItalyDipartimento di Farmacia, Università degli Studi di Napoli Federico II, via Domenico Montesano 49, Napoli 80131, ItalyDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, via Sergio Pansini 5, Napoli 80131, ItalyDipartimento di Farmacia, Università degli Studi di Napoli Federico II, via Domenico Montesano 49, Napoli 80131, ItalyHerein, we report on the synthesis of a small set of linear precursors of an inosine analogue of cyclic ADP-ribose (cADPR), a second messenger involved in Ca<sup>2+</sup> mobilization from ryanodine receptor stores firstly isolated from sea urchin eggs extracts. The synthesized compounds were obtained starting from inosine and are characterized by an N1-alkyl chain replacing the “northern” ribose and a phosphate group attached at the end of the N1-alkyl chain and/or 5′-sugar positions. Preliminary Ca<sup>2+</sup> mobilization assays, performed on differentiated C2C12 cells, are reported as well.https://www.mdpi.com/1660-3397/17/8/476cADPRryanodine receptorsneuroblastomacaffeinecalcium mobilizationphosphorylationC2C12 cellsIP3 |
| spellingShingle | Stefano D’Errico Emy Basso Andrea Patrizia Falanga Maria Marzano Tullio Pozzan Vincenzo Piccialli Gennaro Piccialli Giorgia Oliviero Nicola Borbone New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca<sup>2+</sup>-Modulating Activity Isolated from Sea Urchin Eggs Marine Drugs cADPR ryanodine receptors neuroblastoma caffeine calcium mobilization phosphorylation C2C12 cells IP3 |
| title | New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca<sup>2+</sup>-Modulating Activity Isolated from Sea Urchin Eggs |
| title_full | New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca<sup>2+</sup>-Modulating Activity Isolated from Sea Urchin Eggs |
| title_fullStr | New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca<sup>2+</sup>-Modulating Activity Isolated from Sea Urchin Eggs |
| title_full_unstemmed | New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca<sup>2+</sup>-Modulating Activity Isolated from Sea Urchin Eggs |
| title_short | New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca<sup>2+</sup>-Modulating Activity Isolated from Sea Urchin Eggs |
| title_sort | new linear precursors of cidpr derivatives as stable analogs of cadpr a potent second messenger with ca sup 2 sup modulating activity isolated from sea urchin eggs |
| topic | cADPR ryanodine receptors neuroblastoma caffeine calcium mobilization phosphorylation C2C12 cells IP3 |
| url | https://www.mdpi.com/1660-3397/17/8/476 |
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