New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca<sup>2+</sup>-Modulating Activity Isolated from Sea Urchin Eggs

New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca<sup>2+</sup>-Modulating Activity Isolated from Sea Urchin Eggs

Herein, we report on the synthesis of a small set of linear precursors of an inosine analogue of cyclic ADP-ribose (cADPR), a second messenger involved in Ca<sup>2+</sup> mobilization from ryanodine receptor stores firstly isolated from sea urchin eggs extracts. The synthesized compounds...

Full description

Bibliographic Details
Main Authors:	Stefano D’Errico, Emy Basso, Andrea Patrizia Falanga, Maria Marzano, Tullio Pozzan, Vincenzo Piccialli, Gennaro Piccialli, Giorgia Oliviero, Nicola Borbone
Format:	Article
Language:	English
Published:	MDPI AG 2019-08-01
Series:	Marine Drugs
Subjects:	cADPR ryanodine receptors neuroblastoma caffeine calcium mobilization phosphorylation C2C12 cells IP3
Online Access:	https://www.mdpi.com/1660-3397/17/8/476

Similar Items

Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
by: Lihe Zhang, et al.
Published: (2010-11-01)

Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs
by: Stefano D’Errico, et al.
Published: (2018-03-01)

Solid-Phase Synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) Derivative and Studies toward Cyclic AICAR Diphosphate Ribose
by: Gennaro Piccialli, et al.
Published: (2011-09-01)

O6-[(2″,3″-<i>O</i>-Isopropylidene-5″-<i>O</i>-<i><sup>t</sup></i>butyldimethylsilyl)pentyl]-5′-<i>O</i>-<i><sup>t</sup></i>butyldiphenylsilyl-2′,3′-<i>O</i>-isopropylideneinosine
by: Maria Marzano, et al.
Published: (2022-03-01)

Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?
by: Ralf Fliegert, et al.
Published: (2020-08-01)

Interactions between intracellular Ca2+ stores: Ca2+ released from the NAADP pool potentiates cADPR-induced Ca2+ release
by: E.N. Chini
Published: (2002-05-01)

CD38-cADPR-SERCA Signaling Axis Determines Skeletal Muscle Contractile Force in Response to β-Adrenergic Stimulation
by: Dae-Ryoung Park, et al.
Published: (2018-04-01)

25 Years of Collaboration with A Genius: Deciphering Adenine Nucleotide Ca<sup>2+</sup> Mobilizing Second Messengers Together with Professor Barry Potter
by: Andreas H. Guse
Published: (2020-09-01)

Remifentanil-induced postoperative hyperalgesia is attenuated by inhibition of NMDAR-cADPR-RyRs signaling pathway in the spinal cord of rats
by: QIAN Yue, WANG Fang, ZHANG Jing, XIA Tianjiao, GU Xiaoping
Published: (2023-09-01)

Enzymology of Ca<sup>2+</sup>-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases
by: Andreas H. Guse
Published: (2023-02-01)

Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-<i>N</i>1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship
by: Joanna M. Watt, et al.
Published: (2021-11-01)

On a Magical Mystery Tour with 8-Bromo-Cyclic ADP-Ribose: From All-or-None Block to Nanojunctions and the Cell-Wide Web
by: A. Mark Evans
Published: (2020-10-01)

To be or not to be… Nicotinic acid adenine dinucleotide phosphate (NAADP): A new intracellular second messenger?
by: EDUARDO NUNES CHINI
Published: (2004-01-01)

An ADPRS variant disrupts ARH3 stability and subcellular localization in children with neurodegeneration and respiratory failure
by: Maxwell Bannister, et al.
Published: (2025-01-01)

2′-deoxy-ADPR activates human TRPM2 faster than ADPR and thereby induces higher currents at physiological Ca2+ concentrations
by: Jelena Pick, et al.
Published: (2024-01-01)

NAADP and cADPR signalling in sea urchin eggs
by: Galione, A, et al.
Published: (2005)

cADPR stimulates SERCA activity in Xenopus oocytes.
by: Yamasaki-Mann, M, et al.
Published: (2009)

Investigating cADPR and NAADP in intact and broken cell preparations.
by: Morgan, A, et al.
Published: (2008)

Exploring the Parallel G-Quadruplex Nucleic Acid World: A Spectroscopic and Computational Investigation on the Binding of the c-myc Oncogene NHE III1 Region by the Phytochemical Polydatin
by: Francesca Greco, et al.
Published: (2022-05-01)

The Use of [<sup>11</sup>C]C-Methionine in Diagnostics of Endocrine Disorders with Focus on Pituitary and Parathyroid Glands
by: Adam Daniel Durma, et al.
Published: (2025-02-01)

Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket
by: Peilin Yu, et al.
Published: (2019-06-01)

Requirement of calmodulin for actions of cADPR in guinea-pig ventricular myocytes
by: Rakovic, S, et al.
Published: (2002)

Carvedilol inhibits cADPR- and IP3-induced Ca2+ release
by: Morgan, A, et al.
Published: (2017)

β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart.
by: Lewis, A, et al.
Published: (2012)

ß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart
by: Lewis, A, et al.
Published: (2012)

CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms
by: Deepak A. Deshpande, et al.
Published: (2018-01-01)

BCI Applications to Creativity: Review and Future Directions, from little-c to C<sup>2</sup>
by: Maria Elide Vanutelli, et al.
Published: (2023-04-01)

Fluorescent Probe for Ag<sup>+</sup> Detection Using SYBR GREEN I and C-C Mismatch
by: Xiaohong Zhou, et al.
Published: (2020-12-01)

Evaluation of an Analogue of the Marine ε-PLL Peptide as a Ligand of G-quadruplex DNA Structures
by: Maria Marzano, et al.
Published: (2020-01-01)

Child-Onset Cerebellar Ataxia Caused by Two Compound Heterozygous Variants in ADPRS Gene: A Case Report
by: Jiehui Ma, et al.
Published: (2022-05-01)

Pharmacological characteristics of [P-32] cADPR binding to sea urchin egg homogenate
by: Thomas, J, et al.
Published: (2000)

Calmodulin dissociation mediates desensitization of the cADPR-induced Ca2+ release mechanism.
by: Thomas, J, et al.
Published: (2002)

Nonstandard Hulls of <i>C</i><sup>*</sup>-Algebras and Their Applications
by: Stefano Baratella
Published: (2021-10-01)

The Role of Ca<sup>2+</sup> Signaling in Aging and Neurodegeneration: Insights from <i>Caenorhabditis elegans</i> Models
by: Javier Alvarez, et al.
Published: (2020-01-01)

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers
by: Watt, J, et al.
Published: (2018)

The functional roles of Ca2+ mobilizing pyridine nucleotides cADPR and NAADP in detrusor and taenia caceum
by: Durlu-Kandilci, N, et al.
Published: (2007)

Optimization of Molecular Dynamics Simulations of c-MYC<sup>1-88</sup>—An Intrinsically Disordered System
by: Sandra S. Sullivan, et al.
Published: (2020-07-01)

Foot-and-Mouth Disease Virus 3C<sup>pro</sup> Cleaves BP180 to Induce Blister Formation
by: Pathum Ekanayaka, et al.
Published: (2022-09-01)

Reactions of an Anionic Gallylene with Azobenzene or Azide Compounds Through C(sp<sup>2</sup>)–H and C(sp<sup>3</sup>)–H Activation
by: Jinfeng Sun, et al.
Published: (2024-10-01)

Direct Electrochemical C(sp<sup>3</sup>)–H Amidation Enabled by Hexafluoroisopropanol (HFIP)
by: Fengyi Li, et al.
Published: (2023-10-01)