Precise Neurotransmitter-Mediated Communication with Neurons In Vitro and In Vivo Using Organic Electronics
Attempts to interface human-made systems with neural systems are commonly based on direct electrical stimulation or exogenous drug delivery. Few techniques have attempted to mimic neurons' own combination of electronic and chemical signaling with endogenous substances. We demonstrate below...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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The Japan Society of Mechanical Engineers
2010-04-01
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| Series: | Journal of Biomechanical Science and Engineering |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jbse/5/3/5_3_208/_pdf/-char/en |
| _version_ | 1811296793263079424 |
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| author | Daniel T. SIMON Karin C. LARSSON Magnus BERGGREN Agneta RICHTER-DAHLFORS |
| author_facet | Daniel T. SIMON Karin C. LARSSON Magnus BERGGREN Agneta RICHTER-DAHLFORS |
| author_sort | Daniel T. SIMON |
| collection | DOAJ |
| description | Attempts to interface human-made systems with neural systems are commonly based on direct electrical stimulation or exogenous drug delivery. Few techniques have attempted to mimic neurons' own combination of electronic and chemical signaling with endogenous substances. We demonstrate below the organic electronic ion pump (OEIP), a technology which aims to accomplish just that: electronically controlled delivery of ions, neurotransmitters and other bio-substances. Based on electrophoretic migration through an organic electronic system, delivery is diffusive and non-convective, that is, without fluid flow. Various experiments involving OEIP technology are reviewed, culminating in its use, in an encapsulated form, to modulate sensory function in a living animal. As a first step towards an “artificial neuron”, this technology has significant potential for both neural system interfacing and in the treatment of various neurological disorders. |
| first_indexed | 2024-04-13T05:53:51Z |
| format | Article |
| id | doaj.art-34d560a840af4d908b5ed0438a74b9a1 |
| institution | Directory Open Access Journal |
| issn | 1880-9863 |
| language | English |
| last_indexed | 2024-04-13T05:53:51Z |
| publishDate | 2010-04-01 |
| publisher | The Japan Society of Mechanical Engineers |
| record_format | Article |
| series | Journal of Biomechanical Science and Engineering |
| spelling | doaj.art-34d560a840af4d908b5ed0438a74b9a12022-12-22T02:59:40ZengThe Japan Society of Mechanical EngineersJournal of Biomechanical Science and Engineering1880-98632010-04-015320821710.1299/jbse.5.208jbsePrecise Neurotransmitter-Mediated Communication with Neurons In Vitro and In Vivo Using Organic ElectronicsDaniel T. SIMON0Karin C. LARSSON1Magnus BERGGREN2Agneta RICHTER-DAHLFORS3Swedish Medical Nanoscience Center, Karolinska InstitutetSwedish Medical Nanoscience Center, Karolinska InstitutetDepartment of Science and Technology (ITN), Linköping UniversitySwedish Medical Nanoscience Center, Karolinska InstitutetAttempts to interface human-made systems with neural systems are commonly based on direct electrical stimulation or exogenous drug delivery. Few techniques have attempted to mimic neurons' own combination of electronic and chemical signaling with endogenous substances. We demonstrate below the organic electronic ion pump (OEIP), a technology which aims to accomplish just that: electronically controlled delivery of ions, neurotransmitters and other bio-substances. Based on electrophoretic migration through an organic electronic system, delivery is diffusive and non-convective, that is, without fluid flow. Various experiments involving OEIP technology are reviewed, culminating in its use, in an encapsulated form, to modulate sensory function in a living animal. As a first step towards an “artificial neuron”, this technology has significant potential for both neural system interfacing and in the treatment of various neurological disorders.https://www.jstage.jst.go.jp/article/jbse/5/3/5_3_208/_pdf/-char/enorganic electronicsdrug deliveryneurotransmitterselectrophoresisin vivo |
| spellingShingle | Daniel T. SIMON Karin C. LARSSON Magnus BERGGREN Agneta RICHTER-DAHLFORS Precise Neurotransmitter-Mediated Communication with Neurons In Vitro and In Vivo Using Organic Electronics Journal of Biomechanical Science and Engineering organic electronics drug delivery neurotransmitters electrophoresis in vivo |
| title | Precise Neurotransmitter-Mediated Communication with Neurons In Vitro and In Vivo Using Organic Electronics |
| title_full | Precise Neurotransmitter-Mediated Communication with Neurons In Vitro and In Vivo Using Organic Electronics |
| title_fullStr | Precise Neurotransmitter-Mediated Communication with Neurons In Vitro and In Vivo Using Organic Electronics |
| title_full_unstemmed | Precise Neurotransmitter-Mediated Communication with Neurons In Vitro and In Vivo Using Organic Electronics |
| title_short | Precise Neurotransmitter-Mediated Communication with Neurons In Vitro and In Vivo Using Organic Electronics |
| title_sort | precise neurotransmitter mediated communication with neurons in vitro and in vivo using organic electronics |
| topic | organic electronics drug delivery neurotransmitters electrophoresis in vivo |
| url | https://www.jstage.jst.go.jp/article/jbse/5/3/5_3_208/_pdf/-char/en |
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