Effects of Maternal Vitamin D Deficiency on the Newborn: A Cohort Study
Introduction: Vitamin D deficiency occurs during pregnancy all over the world because of lifestyle modifications, less sun exposure, sunscreen application and reduced amount of vitamin D in diet. At present, there are very limited number of studies regarding the prevalence of vitamin D deficienc...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Pvt. Ltd.
2021-10-01
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| Series: | Indian Journal of Neonatal Medicine and Research |
| Subjects: | |
| Online Access: | http://www.ijnmr.net/articles/PDF/2318/47986_CE[Ra1]_F(SHU)_PF1(SA_SL)_PF2(SG_SL)_PFA(SG_SL)_PN(SL).pdf |
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| author | RAMESH SONOWAL MONIGOPA DAS BIPUL PRASAD DEKA PRITAM DAS |
| author_facet | RAMESH SONOWAL MONIGOPA DAS BIPUL PRASAD DEKA PRITAM DAS |
| author_sort | RAMESH SONOWAL |
| collection | DOAJ |
| description | Introduction: Vitamin D deficiency occurs during pregnancy
all over the world because of lifestyle modifications, less sun
exposure, sunscreen application and reduced amount of
vitamin D in diet. At present, there are very limited number
of studies regarding the prevalence of vitamin D deficiency
during pregnancy and its effects in the newborns in the North
Eastern region of India.
Aim: To estimate serum vitamin D levels in pregnant women
and newborn and correlation between maternal and newborn
hypovitaminosis D. The study also assess the association of
maternal vitamin D levels with the outcomes of early neonatal
period.
Materials and Methods: A prospective cohort study was
conducted in Assam Medical College and Hospital (AMCH),
Dibrugarh, Assam, India, in the Obstetrics and Gynaecology
Department over a period of one year (1st July 2019 to
30th June 2020). Seventy pregnant women attending antenatal
ward, labour room of AMCH were recruited. The 25-hydroxy
vitamin D level was assessed in the maternal and cord blood.
Delivery details and foetal parameters were recorded. Primary
outcome was to assess the correlation between maternal
and cord blood vitamin D level and secondary outcome
was to assess the association of maternal vitamin D level
with demographic characteristics, economic and obstetrical
characteristics, newborn characteristics and perinatal outcome.
Analysis of Variance (ANOVA), chi-square test and Fischer’sexact test, Pearson’s correlation coefficient (r) were used for
statistical analysis.
Results: Out of 70 participants, majority of the pregnant women
(61.43%) were vitamin D deficient, 22.86% were vitamin D
insufficient and 15.71% had sufficient vitamin D levels. Maternal
vitamin D level was significantly associated with maternal age
(p=0.0043) and socio-economic status (p=0.0417). There was a
significant positive association between the vitamin D level of the
mother with the birth weight (p<0.001), birth length (p=0.0001),
head circumference (p=0.0003) and chest circumference
(p=0.001) of the newborns and also a positive correlation was
found between the vitamin D level of the mother and the cord
blood (r=0.984). There was a significant association between
the vitamin D level of the mother and perinatal outcomes such
as Neonatal Intensive Care Unit (NICU) admission (p=0.0169)
and Respiratory Distress Syndrome (RDS) (p=0.0029).
Conclusion: The study shows that there is a high prevalence
of vitamin D deficiency during pregnancy in North Eastern
part of India and it has a significant role in foetal development
and perinatal outcomes. |
| first_indexed | 2024-12-20T09:10:11Z |
| format | Article |
| id | doaj.art-34d602353d3249c69d968357e71e4bb7 |
| institution | Directory Open Access Journal |
| issn | 2277-8527 2455-6890 |
| language | English |
| last_indexed | 2024-12-20T09:10:11Z |
| publishDate | 2021-10-01 |
| publisher | JCDR Research and Publications Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Neonatal Medicine and Research |
| spelling | doaj.art-34d602353d3249c69d968357e71e4bb72022-12-21T19:45:36ZengJCDR Research and Publications Pvt. Ltd.Indian Journal of Neonatal Medicine and Research2277-85272455-68902021-10-0194PO27PO3210.7860/IJNMR/2021/47986.2318Effects of Maternal Vitamin D Deficiency on the Newborn: A Cohort StudyRAMESH SONOWAL0MONIGOPA DAS1BIPUL PRASAD DEKA2PRITAM DAS3Professor and Head, Department of Obstetrics and Gynaecology, Assam Medical College and Hospital, Dibrugarh, Assam, India.Professor, Department of Biochemistry, Assam Medical College and Hospital, Dibrugarh, Assam, India.Assistant Professor, Department of Obstetrics and Gynaecology, Assam Medical College and Hospital, Dibrugarh, Assam, India.Postgraduate Student, Department of Obstetrics and Gynaecology, Assam Medical College and Hospital, Dibrugarh, Assam, India.Introduction: Vitamin D deficiency occurs during pregnancy all over the world because of lifestyle modifications, less sun exposure, sunscreen application and reduced amount of vitamin D in diet. At present, there are very limited number of studies regarding the prevalence of vitamin D deficiency during pregnancy and its effects in the newborns in the North Eastern region of India. Aim: To estimate serum vitamin D levels in pregnant women and newborn and correlation between maternal and newborn hypovitaminosis D. The study also assess the association of maternal vitamin D levels with the outcomes of early neonatal period. Materials and Methods: A prospective cohort study was conducted in Assam Medical College and Hospital (AMCH), Dibrugarh, Assam, India, in the Obstetrics and Gynaecology Department over a period of one year (1st July 2019 to 30th June 2020). Seventy pregnant women attending antenatal ward, labour room of AMCH were recruited. The 25-hydroxy vitamin D level was assessed in the maternal and cord blood. Delivery details and foetal parameters were recorded. Primary outcome was to assess the correlation between maternal and cord blood vitamin D level and secondary outcome was to assess the association of maternal vitamin D level with demographic characteristics, economic and obstetrical characteristics, newborn characteristics and perinatal outcome. Analysis of Variance (ANOVA), chi-square test and Fischer’sexact test, Pearson’s correlation coefficient (r) were used for statistical analysis. Results: Out of 70 participants, majority of the pregnant women (61.43%) were vitamin D deficient, 22.86% were vitamin D insufficient and 15.71% had sufficient vitamin D levels. Maternal vitamin D level was significantly associated with maternal age (p=0.0043) and socio-economic status (p=0.0417). There was a significant positive association between the vitamin D level of the mother with the birth weight (p<0.001), birth length (p=0.0001), head circumference (p=0.0003) and chest circumference (p=0.001) of the newborns and also a positive correlation was found between the vitamin D level of the mother and the cord blood (r=0.984). There was a significant association between the vitamin D level of the mother and perinatal outcomes such as Neonatal Intensive Care Unit (NICU) admission (p=0.0169) and Respiratory Distress Syndrome (RDS) (p=0.0029). Conclusion: The study shows that there is a high prevalence of vitamin D deficiency during pregnancy in North Eastern part of India and it has a significant role in foetal development and perinatal outcomes.http://www.ijnmr.net/articles/PDF/2318/47986_CE[Ra1]_F(SHU)_PF1(SA_SL)_PF2(SG_SL)_PFA(SG_SL)_PN(SL).pdfhypovitaminosis dinfantile ricketsnewborn outcomesnutritional deficiencypregnant women |
| spellingShingle | RAMESH SONOWAL MONIGOPA DAS BIPUL PRASAD DEKA PRITAM DAS Effects of Maternal Vitamin D Deficiency on the Newborn: A Cohort Study Indian Journal of Neonatal Medicine and Research hypovitaminosis d infantile rickets newborn outcomes nutritional deficiency pregnant women |
| title | Effects of Maternal Vitamin D Deficiency on the Newborn: A Cohort Study |
| title_full | Effects of Maternal Vitamin D Deficiency on the Newborn: A Cohort Study |
| title_fullStr | Effects of Maternal Vitamin D Deficiency on the Newborn: A Cohort Study |
| title_full_unstemmed | Effects of Maternal Vitamin D Deficiency on the Newborn: A Cohort Study |
| title_short | Effects of Maternal Vitamin D Deficiency on the Newborn: A Cohort Study |
| title_sort | effects of maternal vitamin d deficiency on the newborn a cohort study |
| topic | hypovitaminosis d infantile rickets newborn outcomes nutritional deficiency pregnant women |
| url | http://www.ijnmr.net/articles/PDF/2318/47986_CE[Ra1]_F(SHU)_PF1(SA_SL)_PF2(SG_SL)_PFA(SG_SL)_PN(SL).pdf |
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