mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation
Autophagy relies on coordinated fusion of organelle membranes, although the interplay between the regulatory machinery is not well studied. Here, the authors show that SNARE complex formation is inhibited by mTORC1 phosphorylation of VAMP8, which prevents autophagosome-lysosome fusion.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26824-5 |
| _version_ | 1818990533494702080 |
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| author | Hong Huang Qinqin Ouyang Min Zhu Haijia Yu Kunrong Mei Rong Liu |
| author_facet | Hong Huang Qinqin Ouyang Min Zhu Haijia Yu Kunrong Mei Rong Liu |
| author_sort | Hong Huang |
| collection | DOAJ |
| description | Autophagy relies on coordinated fusion of organelle membranes, although the interplay between the regulatory machinery is not well studied. Here, the authors show that SNARE complex formation is inhibited by mTORC1 phosphorylation of VAMP8, which prevents autophagosome-lysosome fusion. |
| first_indexed | 2024-12-20T19:55:53Z |
| format | Article |
| id | doaj.art-34d729342eb24e5ea2c8dc490fe613ff |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T19:55:53Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-34d729342eb24e5ea2c8dc490fe613ff2022-12-21T19:28:10ZengNature PortfolioNature Communications2041-17232021-11-0112111510.1038/s41467-021-26824-5mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturationHong Huang0Qinqin Ouyang1Min Zhu2Haijia Yu3Kunrong Mei4Rong Liu5College of Food Science and Technology, Nanjing Agricultural UniversityCollege of Food Science and Technology, Nanjing Agricultural UniversityJiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal UniversityJiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal UniversitySchool of Pharmaceutical Science and Technology, Tianjin UniversityCollege of Food Science and Technology, Nanjing Agricultural UniversityAutophagy relies on coordinated fusion of organelle membranes, although the interplay between the regulatory machinery is not well studied. Here, the authors show that SNARE complex formation is inhibited by mTORC1 phosphorylation of VAMP8, which prevents autophagosome-lysosome fusion.https://doi.org/10.1038/s41467-021-26824-5 |
| spellingShingle | Hong Huang Qinqin Ouyang Min Zhu Haijia Yu Kunrong Mei Rong Liu mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation Nature Communications |
| title | mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation |
| title_full | mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation |
| title_fullStr | mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation |
| title_full_unstemmed | mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation |
| title_short | mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation |
| title_sort | mtor mediated phosphorylation of vamp8 and scfd1 regulates autophagosome maturation |
| url | https://doi.org/10.1038/s41467-021-26824-5 |
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