Current state of immune checkpoints therapy for glioblastoma
Glioblastoma (GBM), one of the most aggressive forms of brain cancer, has limited treatment options. Recent years have witnessed the remarkable success of checkpoint inhibitor immunotherapy across various cancer types. Against this backdrop, several clinical trials investigating checkpoint inhibitor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024007606 |
| _version_ | 1827360807445331968 |
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| author | He Wang Jing Yang Xiangjun Li Hai Zhao |
| author_facet | He Wang Jing Yang Xiangjun Li Hai Zhao |
| author_sort | He Wang |
| collection | DOAJ |
| description | Glioblastoma (GBM), one of the most aggressive forms of brain cancer, has limited treatment options. Recent years have witnessed the remarkable success of checkpoint inhibitor immunotherapy across various cancer types. Against this backdrop, several clinical trials investigating checkpoint inhibitors for GBM are underway in multiple countries. Furthermore, the integration of immunotherapy with traditional treatment approaches is now emerging as a highly promising strategy. This review summarizes the latest advancements in checkpoint inhibitor immunotherapy for GBM treatment. We provide a concise yet comprehensive overview of current GBM immunotherapy options. Additionally, this review underscores combination strategies and potential biomarkers for predicting response and resistance in GBM immunotherapies. |
| first_indexed | 2024-03-08T06:53:45Z |
| format | Article |
| id | doaj.art-34d78f5879694516932f822fb8c7c6ee |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T06:53:45Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-34d78f5879694516932f822fb8c7c6ee2024-02-03T06:38:18ZengElsevierHeliyon2405-84402024-01-01102e24729Current state of immune checkpoints therapy for glioblastomaHe Wang0Jing Yang1Xiangjun Li2Hai Zhao3Department of Neurosurgery, the Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, Shandong, 266005, ChinaDepartment of Emergency Surgery, the Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, Shandong, 266005, ChinaSchool of medicine, Department of Breast surgery, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, 266000, ChinaDepartment of Neurosurgery, the Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, Shandong, 266005, China; Corresponding author.Glioblastoma (GBM), one of the most aggressive forms of brain cancer, has limited treatment options. Recent years have witnessed the remarkable success of checkpoint inhibitor immunotherapy across various cancer types. Against this backdrop, several clinical trials investigating checkpoint inhibitors for GBM are underway in multiple countries. Furthermore, the integration of immunotherapy with traditional treatment approaches is now emerging as a highly promising strategy. This review summarizes the latest advancements in checkpoint inhibitor immunotherapy for GBM treatment. We provide a concise yet comprehensive overview of current GBM immunotherapy options. Additionally, this review underscores combination strategies and potential biomarkers for predicting response and resistance in GBM immunotherapies.http://www.sciencedirect.com/science/article/pii/S2405844024007606GBMCheckpoint inhibitorImmunotherapyCombination therapy |
| spellingShingle | He Wang Jing Yang Xiangjun Li Hai Zhao Current state of immune checkpoints therapy for glioblastoma Heliyon GBM Checkpoint inhibitor Immunotherapy Combination therapy |
| title | Current state of immune checkpoints therapy for glioblastoma |
| title_full | Current state of immune checkpoints therapy for glioblastoma |
| title_fullStr | Current state of immune checkpoints therapy for glioblastoma |
| title_full_unstemmed | Current state of immune checkpoints therapy for glioblastoma |
| title_short | Current state of immune checkpoints therapy for glioblastoma |
| title_sort | current state of immune checkpoints therapy for glioblastoma |
| topic | GBM Checkpoint inhibitor Immunotherapy Combination therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024007606 |
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