Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (<i>Ananas comosus</i>) and Their Possible Therapeutic and Clinical Effects. A Summary
Bromelain is a complex combination of multiple endopeptidases of thiol and other compounds derived from the pineapple fruit, stem and/or root. Fruit bromelain and stem bromelain are produced completely distinctly and comprise unique compounds of enzymes, and the descriptor “Bromelain” originally ref...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/10/10/2249 |
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| author | Carolina Varilla Massimo Marcone Lisete Paiva Jose Baptista |
| author_facet | Carolina Varilla Massimo Marcone Lisete Paiva Jose Baptista |
| author_sort | Carolina Varilla |
| collection | DOAJ |
| description | Bromelain is a complex combination of multiple endopeptidases of thiol and other compounds derived from the pineapple fruit, stem and/or root. Fruit bromelain and stem bromelain are produced completely distinctly and comprise unique compounds of enzymes, and the descriptor “Bromelain” originally referred in actuality to stem bromelain. Due to the efficacy of oral administration in the body, as a safe phytotherapeutic medication, bromelain was commonly suited for patients due to lack of compromise in its peptidase efficacy and the absence of undesired side effects. Various in vivo and in vitro studies have shown that they are anti-edematous, anti-inflammatory, anti-cancerous, anti-thrombotic, fibrinolytic, and facilitate the death of apoptotic cells. The pharmacological properties of bromelain are, in part, related to its arachidonate cascade modulation, inhibition of platelet aggregation, such as interference with malignant cell growth; anti-inflammatory action; fibrinolytic activity; skin debridement properties, and reduction of the severe effects of SARS-Cov-2. In this paper, we concentrated primarily on the potential of bromelain’s important characteristics and meditative and therapeutic effects, along with the possible mechanism of action. |
| first_indexed | 2024-03-10T06:34:28Z |
| format | Article |
| id | doaj.art-34df05fa9e1847c8913b95913e097261 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T06:34:28Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-34df05fa9e1847c8913b95913e0972612023-11-22T18:13:03ZengMDPI AGFoods2304-81582021-09-011010224910.3390/foods10102249Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (<i>Ananas comosus</i>) and Their Possible Therapeutic and Clinical Effects. A SummaryCarolina Varilla0Massimo Marcone1Lisete Paiva2Jose Baptista3Department of Food Science, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Food Science, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Science of Physics, Chemistry and Engineering (DCFCE), Institute for Investigation and Technology of Agronomy and Environment (IITAA), University of Azores, 9500-321 Azores, PortugalDepartment of Science of Physics, Chemistry and Engineering (DCFCE), Institute for Investigation and Technology of Agronomy and Environment (IITAA), University of Azores, 9500-321 Azores, PortugalBromelain is a complex combination of multiple endopeptidases of thiol and other compounds derived from the pineapple fruit, stem and/or root. Fruit bromelain and stem bromelain are produced completely distinctly and comprise unique compounds of enzymes, and the descriptor “Bromelain” originally referred in actuality to stem bromelain. Due to the efficacy of oral administration in the body, as a safe phytotherapeutic medication, bromelain was commonly suited for patients due to lack of compromise in its peptidase efficacy and the absence of undesired side effects. Various in vivo and in vitro studies have shown that they are anti-edematous, anti-inflammatory, anti-cancerous, anti-thrombotic, fibrinolytic, and facilitate the death of apoptotic cells. The pharmacological properties of bromelain are, in part, related to its arachidonate cascade modulation, inhibition of platelet aggregation, such as interference with malignant cell growth; anti-inflammatory action; fibrinolytic activity; skin debridement properties, and reduction of the severe effects of SARS-Cov-2. In this paper, we concentrated primarily on the potential of bromelain’s important characteristics and meditative and therapeutic effects, along with the possible mechanism of action.https://www.mdpi.com/2304-8158/10/10/2249<i>Ananas comosus</i>bromelainproteinasespineapple plantphytotherapeutic applicationsanti-inflammatory effect |
| spellingShingle | Carolina Varilla Massimo Marcone Lisete Paiva Jose Baptista Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (<i>Ananas comosus</i>) and Their Possible Therapeutic and Clinical Effects. A Summary Foods <i>Ananas comosus</i> bromelain proteinases pineapple plant phytotherapeutic applications anti-inflammatory effect |
| title | Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (<i>Ananas comosus</i>) and Their Possible Therapeutic and Clinical Effects. A Summary |
| title_full | Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (<i>Ananas comosus</i>) and Their Possible Therapeutic and Clinical Effects. A Summary |
| title_fullStr | Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (<i>Ananas comosus</i>) and Their Possible Therapeutic and Clinical Effects. A Summary |
| title_full_unstemmed | Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (<i>Ananas comosus</i>) and Their Possible Therapeutic and Clinical Effects. A Summary |
| title_short | Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (<i>Ananas comosus</i>) and Their Possible Therapeutic and Clinical Effects. A Summary |
| title_sort | bromelain a group of pineapple proteolytic complex enzymes i ananas comosus i and their possible therapeutic and clinical effects a summary |
| topic | <i>Ananas comosus</i> bromelain proteinases pineapple plant phytotherapeutic applications anti-inflammatory effect |
| url | https://www.mdpi.com/2304-8158/10/10/2249 |
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