Controlled polymerization in microfluidics: Advancement in nanogel synthesis
Abstract This comprehensive review provides a detailed examination of controlled polymerization in the development of nanogels‐based microfluidic devices. Here, we have explored the integration of atom transfer radical polymerization (ATRP) and reversible addition‐fragmentation chain transfer (RAFT)...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-04-01
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| Series: | SPE Polymers |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/pls2.10116 |
| _version_ | 1827288114050105344 |
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| author | Tejasvi Pandey Aditi Sharma Anuradha Sandhu Vivek Pandey |
| author_facet | Tejasvi Pandey Aditi Sharma Anuradha Sandhu Vivek Pandey |
| author_sort | Tejasvi Pandey |
| collection | DOAJ |
| description | Abstract This comprehensive review provides a detailed examination of controlled polymerization in the development of nanogels‐based microfluidic devices. Here, we have explored the integration of atom transfer radical polymerization (ATRP) and reversible addition‐fragmentation chain transfer (RAFT) techniques within microfluidic platforms for the synthesis of nanogels. The synergistic combination of ATRP and RAFT with microfluidics has emerged as a powerful tool for precise control over polymerization reactions, enabling the fabrication of well‐defined, multifunctional nanogels with tailored properties. The review begins with a thorough introduction to the principles of ATRP and RAFT, highlighting their respective advantages in controlled radical polymerization. Subsequently, it elucidates the principles of microfluidics and its profound impact on polymerization processes. The merging of these techniques enables precise control over reaction kinetics, monomer conversions, and molecular weight distributions, facilitating the synthesis of nanogels with unprecedented precision and reproducibility. Furthermore, this review delves into the chemical mechanisms underlying ATRP and RAFT reactions in microfluidic environments, emphasizing the role of various initiators, catalysts, and chain transfer agents. Special attention is given to the impact of microscale flow conditions on reaction kinetics and polymer structure. In addition, the review discusses emerging trends in the field, such as the incorporation of novel monomers and the exploration of environmentally benign reaction conditions. Highlights The controlled polymerization is the mechanism by which we can obtain tailormade material. The nanogel synthesis must ensure the gelation to be in confined dimensions here microfluidics plays key role. |
| first_indexed | 2024-04-24T11:25:21Z |
| format | Article |
| id | doaj.art-34e01267df4b4d568620930faa6e676e |
| institution | Directory Open Access Journal |
| issn | 2690-3857 |
| language | English |
| last_indexed | 2024-04-24T11:25:21Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | SPE Polymers |
| spelling | doaj.art-34e01267df4b4d568620930faa6e676e2024-04-10T17:21:14ZengWileySPE Polymers2690-38572024-04-015211312610.1002/pls2.10116Controlled polymerization in microfluidics: Advancement in nanogel synthesisTejasvi Pandey0Aditi Sharma1Anuradha Sandhu2Vivek Pandey3Department of Forensic Sciences, School for Bioengineering and Biosciences Sciences Lovely Professional University Jalandhar IndiaDepartment of Forensic Sciences, School for Bioengineering and Biosciences Sciences Lovely Professional University Jalandhar IndiaDepartment of Forensic Sciences, School for Bioengineering and Biosciences Sciences Lovely Professional University Jalandhar IndiaDepartment of Chemistry, School for Chemical Engineering and Physical Sciences Lovely Professional University Jalandhar IndiaAbstract This comprehensive review provides a detailed examination of controlled polymerization in the development of nanogels‐based microfluidic devices. Here, we have explored the integration of atom transfer radical polymerization (ATRP) and reversible addition‐fragmentation chain transfer (RAFT) techniques within microfluidic platforms for the synthesis of nanogels. The synergistic combination of ATRP and RAFT with microfluidics has emerged as a powerful tool for precise control over polymerization reactions, enabling the fabrication of well‐defined, multifunctional nanogels with tailored properties. The review begins with a thorough introduction to the principles of ATRP and RAFT, highlighting their respective advantages in controlled radical polymerization. Subsequently, it elucidates the principles of microfluidics and its profound impact on polymerization processes. The merging of these techniques enables precise control over reaction kinetics, monomer conversions, and molecular weight distributions, facilitating the synthesis of nanogels with unprecedented precision and reproducibility. Furthermore, this review delves into the chemical mechanisms underlying ATRP and RAFT reactions in microfluidic environments, emphasizing the role of various initiators, catalysts, and chain transfer agents. Special attention is given to the impact of microscale flow conditions on reaction kinetics and polymer structure. In addition, the review discusses emerging trends in the field, such as the incorporation of novel monomers and the exploration of environmentally benign reaction conditions. Highlights The controlled polymerization is the mechanism by which we can obtain tailormade material. The nanogel synthesis must ensure the gelation to be in confined dimensions here microfluidics plays key role.https://doi.org/10.1002/pls2.10116ATRPmicrofluidicsnanogelspolymersRAFT |
| spellingShingle | Tejasvi Pandey Aditi Sharma Anuradha Sandhu Vivek Pandey Controlled polymerization in microfluidics: Advancement in nanogel synthesis SPE Polymers ATRP microfluidics nanogels polymers RAFT |
| title | Controlled polymerization in microfluidics: Advancement in nanogel synthesis |
| title_full | Controlled polymerization in microfluidics: Advancement in nanogel synthesis |
| title_fullStr | Controlled polymerization in microfluidics: Advancement in nanogel synthesis |
| title_full_unstemmed | Controlled polymerization in microfluidics: Advancement in nanogel synthesis |
| title_short | Controlled polymerization in microfluidics: Advancement in nanogel synthesis |
| title_sort | controlled polymerization in microfluidics advancement in nanogel synthesis |
| topic | ATRP microfluidics nanogels polymers RAFT |
| url | https://doi.org/10.1002/pls2.10116 |
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