Effects of Apigenin on Pharmacokinetics of Dasatinib and Probable Interaction Mechanism

Effects of Apigenin on Pharmacokinetics of Dasatinib and Probable Interaction Mechanism

Dasatinib (DAS), a narrow-therapeutic index drug, Bcr-Abl, and Src family kinases multitarget inhibitor have been approved for chronic myelogenous leukemia (CML) and Ph-positive acute lymphocytic leukemia (Ph+ ALL). Apigenin (APG) has a long history of human usage in food, herbs, health supplements,...

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Bibliographic Details
Main Authors: Mohammad Raish, Ajaz Ahmad, Mudassar Shahid, Yousef A. Bin Jardan, Abdul Ahad, Mohd Abul Kalam, Mushtaq Ahmad Ansari, Muzaffar Iqbal, Naushad Ali, Khalid M. Alkharfy, Fahad I. Al-Jenoobi
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
dasatinib
sinapic acid
herb drug interactions
PgP/MDR1
BCPR/ABCG2
CYP3A2
Online Access:https://www.mdpi.com/1420-3049/28/4/1602

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