Diagnostic importance of CA-125 in detection of recurrence and progress of the disease in stages III and IV of epithelial ovarian carcinoma
In 60 patients operated in stages III and IV of epithelial ovarian carcinoma continuous determination of CA 125 from serum was done during the following 2 years. The main condition for entering the survey were elevated values of CA 125 in serum > 35 U/mL and histologically verified epithelial ova...
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2008-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2008/1452-82580801030D.pdf |
| _version_ | 1818292766293098496 |
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| author | Đurđević Srđan Stojanović Sanja Vejnović Tihomir Kopitović Vesna Basta-Nikolić Marijana Petrović Đorđe Đorđević Aleksandra |
| author_facet | Đurđević Srđan Stojanović Sanja Vejnović Tihomir Kopitović Vesna Basta-Nikolić Marijana Petrović Đorđe Đorđević Aleksandra |
| author_sort | Đurđević Srđan |
| collection | DOAJ |
| description | In 60 patients operated in stages III and IV of epithelial ovarian carcinoma continuous determination of CA 125 from serum was done during the following 2 years. The main condition for entering the survey were elevated values of CA 125 in serum > 35 U/mL and histologically verified epithelial ovarian carcinoma. The aim of the survey was to perform statistical assessment of serum CA 125 determination in diagnostics of recurrence and progression of the disease in stages III and IV of epithelial ovarian carcinoma, and percentage (%) of false positive and negative results. Determination of CA 125 from serum during 2 postoperative years is a reliable but not completely certain diagnostic parameter in detection of the disease progression in stages III and IV of epithelial ovarian carcinoma (sensitivity 79.3%, specificity 97.1%, positive predictive value 91.2%, negative predictive value 92.4%, test accuracy 92.1%). False positive (0.7%) and false negative results (4.7%) of individual tests were present in 5.4% of all samples. |
| first_indexed | 2024-12-13T03:05:10Z |
| format | Article |
| id | doaj.art-34e0da62f0b642e2b68b135f7c224bcb |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-13T03:05:10Z |
| publishDate | 2008-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-34e0da62f0b642e2b68b135f7c224bcb2022-12-22T00:01:43ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662008-01-0127130341452-82580801030DDiagnostic importance of CA-125 in detection of recurrence and progress of the disease in stages III and IV of epithelial ovarian carcinomaĐurđević Srđan0Stojanović Sanja1Vejnović Tihomir2Kopitović Vesna3Basta-Nikolić Marijana4Petrović Đorđe5Đorđević Aleksandra6Clinic for Gynecology and Obstetrics, Clinical Center of Vojvodina, Novi SadInstitute of Radiology, Clinical Center of Vojvodina, Novi SadClinic for Gynecology and Obstetrics, Clinical Center of Vojvodina, Novi SadClinic for Gynecology and Obstetrics, Clinical Center of Vojvodina, Novi SadInstitute of Radiology, Clinical Center of Vojvodina, Novi SadClinic for Gynecology and Obstetrics, Clinical Center of Vojvodina, Novi SadClinic for Gynecology and Obstetrics, Clinical Center of Vojvodina, Novi SadIn 60 patients operated in stages III and IV of epithelial ovarian carcinoma continuous determination of CA 125 from serum was done during the following 2 years. The main condition for entering the survey were elevated values of CA 125 in serum > 35 U/mL and histologically verified epithelial ovarian carcinoma. The aim of the survey was to perform statistical assessment of serum CA 125 determination in diagnostics of recurrence and progression of the disease in stages III and IV of epithelial ovarian carcinoma, and percentage (%) of false positive and negative results. Determination of CA 125 from serum during 2 postoperative years is a reliable but not completely certain diagnostic parameter in detection of the disease progression in stages III and IV of epithelial ovarian carcinoma (sensitivity 79.3%, specificity 97.1%, positive predictive value 91.2%, negative predictive value 92.4%, test accuracy 92.1%). False positive (0.7%) and false negative results (4.7%) of individual tests were present in 5.4% of all samples.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2008/1452-82580801030D.pdfca 125ovarian carcinomarecurrencediagnostic importance |
| spellingShingle | Đurđević Srđan Stojanović Sanja Vejnović Tihomir Kopitović Vesna Basta-Nikolić Marijana Petrović Đorđe Đorđević Aleksandra Diagnostic importance of CA-125 in detection of recurrence and progress of the disease in stages III and IV of epithelial ovarian carcinoma Journal of Medical Biochemistry ca 125 ovarian carcinoma recurrence diagnostic importance |
| title | Diagnostic importance of CA-125 in detection of recurrence and progress of the disease in stages III and IV of epithelial ovarian carcinoma |
| title_full | Diagnostic importance of CA-125 in detection of recurrence and progress of the disease in stages III and IV of epithelial ovarian carcinoma |
| title_fullStr | Diagnostic importance of CA-125 in detection of recurrence and progress of the disease in stages III and IV of epithelial ovarian carcinoma |
| title_full_unstemmed | Diagnostic importance of CA-125 in detection of recurrence and progress of the disease in stages III and IV of epithelial ovarian carcinoma |
| title_short | Diagnostic importance of CA-125 in detection of recurrence and progress of the disease in stages III and IV of epithelial ovarian carcinoma |
| title_sort | diagnostic importance of ca 125 in detection of recurrence and progress of the disease in stages iii and iv of epithelial ovarian carcinoma |
| topic | ca 125 ovarian carcinoma recurrence diagnostic importance |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2008/1452-82580801030D.pdf |
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